ApoA1

ApoA1 interacts with ABC transporter. The membrane-associated protein encoded by this gene is a
member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport
various molecules across extra- and intracellular membranes. .
ApoA2
Function[edit]
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high
density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or
heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or
hypercholesterolemia.[4]

Interactions[edit]
APOA2 has been shown to interact with PLTPFunction[edit]
The protein encoded by this gene is one of at least two lipid transfer proteins found in human
plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high
density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be
involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have
been found for this gene.

ApoB
Structure[edit]

Editing results in a codon change creating an in frame stop codon leading to translation of a truncated
protein, ApoB48. This stop codon results in the translation of a protein which lacks the carboxyl
terminus which contains the protein's LDLR binding domain. The full protein ApoB100 which has nearly
4500 amino acid is present in VLDL and LDL. Since many parts of ApoB100 are in amphipathic condition,
the structure of some of its domains are dependent on underlying lipid condition. However it is known
to have same over all folding in LDL having five main domains. Recently first structure of LDL at human
body temperature in native condition has been found using cryo-electron microscopy at a resolution of
16 Angstrom.[48] The overall folding of ApoB-100 has been confirmed and some heterogeneity in the
local structure of its domains have been mapped.