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Haematinics, Coagulants and Anticoagulant - DR - Jibachha Sah, M.V.SC, Lecturer
Haematinics, Coagulants and Anticoagulant - DR - Jibachha Sah, M.V.SC, Lecturer
Haematinics, Coagulants and Anticoagulant - DR - Jibachha Sah, M.V.SC, Lecturer
anticoagulants
Dr. Jibachha Sah
M.V.Sc (Pharmacology)
College of Veterinary Science, NPI,
Bhojard,Chitwan
Haematinics
HAEMATINICS are the agents used for formation of blood to treat various types of
anaemia's. These include: Iron, Vitamin B and Folic Acid.
the average size and hemoglobin content of the red blood cells are within normal
limits are called normocytic normochromic anemias.
Classification of Haematinics
Haematinics include iron, folic acid, vitamin B 12, erythropoietin,
myeloid growth factors and megakaryocytic growth factors
Iron
Oral
•Iron gluconate
•Iron sulphate
•Iron fumarate
Parenteral
•Iron dextran (Imferon)
•Sodium ferric gluconate complex
•Iron sucrose (Venofer)
Folic Acid
Vitamin B12
Endogenous
● Methyl cobalamine
● 5-deoxy adenosyl cobalamine
Exogenous
● Cyanocobalamine
● Hydroxycobalamine
Erythropoietin
● Recombinant –apoprotein
● Glycosylated –Darbipoietin alpha
Myeloid Growth Factors
● GM-CSF –Sargramostim
● Interleukin II
● Operlvekin
● Thrombopoietin
The main treatment for hemophilia is called replacement therapy. Concentrates of
clotting factor VIII (for hemophilia A) or clotting factor IX (for hemophilia B) are
slowly dripped or injected into a vein. These infusions help replace the clotting
factor that's missing or low.
Weibel–Palade bodies (WPBs) are the storage granules of endothelial cells, the cells that form
the inner lining of the blood vessels and heart. They store and release two principal molecules,
von Willebrand factor and P-selectin, and thus play a dual role in hemostasis and inflammation.
Fibrinogen (Soluble) Converted to Fibrin (Insoluble):
In turn, thrombin converts fibrinogen (which is also a plasma protein synthesized in the
liver) into fibrin. Fibrin is insoluble and forms the threads that bind the clot
mechanism of coagulation
i. Intrinsic System:
This is initiated by liquid blood making contact with a foreign surface, i. e. something that is not
part of the body; or
These coagulation factors have individual names but are often referred to by a standardised set
of Roman Numerals, e.g. Factor VIII (anti-haemophilic factor), Factor IX (Christmas factor).
Prothrombinase (formed in stage 1.) converts prothrombin, which is a plasma protein that
is formed in the liver, into the enzyme thrombin
Anticoagulants