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Shuttle System
Shuttle System
SHUTTLE SYSTEM
The mitochondrial shuttles are systems used to transport reducing agents across the inner mitochondrial
membrane. NADH cannot cross the membrane, but it can reduce another molecule that can cross the
membrane, so that its electrons can reach the electron transport chain.
Glycerol phosphate shuttle Glycerol 3-phosphate QH2 (~1.5 ATP) Dihydroxyacetone phosphate
Glycerol-3-phosphate Shuttle
In skeletal muscle and brain, the reducing
equivalents from cytoplasmic NADH are transported
to mitochondria asFADH2 through glycerol-3-
phosphate shuttle.
Hence only 1½ ATPs are generated when this
system is operating.
In this shuttle, the enzyme called
cytoplasmic glycerol-3-phosphate dehydrogenase 1
(GPDH-C) converts dihydroxyacetone phosphate (2)
to glycerol 3-phosphate (1) by oxidizing one molecule
of NADH to NAD+ .
Glycerol-3-phosphate Shuttle
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