Name: Natasha Karlina Law NIM:01071190195

Obesity is a familial disorder, which causes early death. Daily exercise can
prevent death

1. Introduction
a) Familial disorder; what faults? Why? gene mutation for obesity
b) Obesity; cause by habit (excessive food, stress, lack of exercise
c) In here, the prevention of early death cause by genetic obesity are
explained.

2. Prevention: regular exercise.

a) How much? frequency
b) What type of exercise? running, swimming (how much calory)

3. Prevention: early detection for complication

a) blood test to detect obesity gene for high risk family member
b) obese: heart coronary block: ECG
c) obese: brain blood block: MRI
d) how regular???

4. Prevention: technology help

a) genetic engineering for high risk couple before marriage
b) Preimplantation genetic diagnosis for embryo of the IVF obese couple

5. Conclusion: basically, early death due to obesity can be prevent as long as it is

well manage, and the patient follow the prevention protocols fit to their
condition

keywords: obesity, familial disorder, daily exercise and (early and preventive)
death
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Lecturer: dr. Rhendy

Name: Natasha Karlina Law NIM:01071190195

1. Introduction
a) Familial disorder; what faults? Why? gene mutation for obesity
b) Obesity; cause by habit (excessive food, stress, lack of exercise
c) In here, the prevention of early death cause by genetic obesity are
explained.

Familial disorder is the condition for which the chances of the disorder to be
expressed more often within the family members (Shield, 2018). The fault of
gene such as Leptin/MMP2 genes promoters' cause childhood obesity (El Sayed
et al., 2018), or MC4R gene (Gimeno-Ferrer et al., 2019).
This disorder is mainly either from genetic or environment. One of the examples
from familial disorder is obesity. Not only that, the chances of death at a young
age is higher, but also the risks to develop other diseases; Heart stroke or
disease, diabetes, high blood pressure, cancers or breathing problems during
sleep (a person stops breathing for a few second when sleeping) and asthma.
However, another alternative way to prevent risk of death is by exercising.

Excessive food consumption can lead to obesity, similarly to

Exercise is one of the factors to reduce obesity, such as, dishwasher, cleaning the
house, walk around the area. It improves energy and better sleeping time, the
key component to have a healthier lifestyle.

There are several methods to predict the One of the methods is BMI (Body Mass-
Index). BMI calculation is considered to be the most efficient and effective
method to determine the group body mass (underweight, normal, overweight
and obese). Moreover, predict the person-overweight as an average. Another
example is the CT scan, it is the most accurate method for measuring tissue,
whole-body fat, lean muscles and bone mass. However there are drawbacks:
pregnant woman and children are not advice to take the CT scan, as there is a

Lecturer: dr. Rhendy

Name: Natasha Karlina Law NIM:01071190195

high ionization radiation across the body, the development of cancer cells. Last
method is waist-to-hip ratio, the

Lecturer: dr. Rhendy

Name: Natasha Karlina Law NIM:01071190195

References

EL SAYED, S., KHAIRY, E., BASHEER, A. R., ZAKI, W. S., AHMAD, G. F. & KASSIM, S.
K. 2018. Evaluation of leptin and MMP2 genes methylation in childhood
obesity. Gene Reports, 11, 79-86.
GIMENO-FERRER, F., ALBUQUERQUE, D., GARCÍA BANACLOY, A., GUZMÁN
LUJÁN, C., VIDAL GARCIA, C., MARCAIDA BENITO, G., SÁNCHEZ JUAN, C.,
BRUNA ESTEBAN, M. & RODRÍGUEZ-LÓPEZ, R. 2019. Genetic screening
for MC4R gene identifies three novel mutations associated with severe
familiar obesity in a cohort of Spanish individuals. Gene, 704, 74-79.
SHIELD, W. 2018. Medical Definition of Familial.

Lecturer: dr. Rhendy