http://journals.tums.ac.ir/abs.aspx?

org_id=59&culture_var=en&journal_id=9&issue_id=613&manuscript_id=5488&segmen
t=fa

Tehran University Medical Journal (TUMJ) 2000;58(3) : 67-69

[ Application of Apium Graveolens in treatment of hypertension ]
[Article in Persian]
Gharooni M, Sarkarati AR
Abstract:
Apium graveolence has an small brown olyptical seed with pharmacological activity. To
evaluate it's application in treatment of hypertension, 37 hypertensive patients (20
female, 17 male) with the age range of 45-65 were given 6 grams of powder of Apium
graveolence seed and then the blood pressures before and after the remedy were
compared. Before treatment, the mean systolic blood pressure was 171.35 mlHg and the
mean diastolic blood pressure was 94 mlHg. After they became 154.3 mlHg and 89.6
mlHg respectively. The difference of blood pressure before and after treatment was
statistically significant (P<0.05), so we concluded that Apium graveolence seed can be
used as is a safe and effective treatment for high blood pressure. Further controlled
studies should be done to compare it with available anti-hypertensive drugs.

http://pubs.acs.org/doi/abs/10.1021/np900117v

Triterpenoids and Flavonoids from

Celery (Apium graveolens)
Kailan Zhou†, Feng Zhao‡, Zhihui Liu†, Yulei Zhuang†, Lixia Chen† and Feng Qiu*†
Department of Natural Products Chemistry, School of Traditional Chinese Materia
Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of
China, and School of Pharmacy, Yantai University, Laishan District, Yantai 264005,
People’s Republic of China
J. Nat. Prod., 2009, 72 (9), pp 1563–1567
DOI: 10.1021/np900117v
Publication Date (Web): August 31, 2009
Copyright © 2009 The American Chemical Society and American Society of
Pharmacognosy

Shenyang Pharmaceutical University.

Yantai University.
,
* Corresponding author. Tel: +86 24 23986463. Fax: +86 24 23993994. E-mail:
fengqiu2000@tom.com.

Abstract
Three new triterpenoids, 11,21-dioxo-2β,3β,15α-trihydroxyurs-12-ene-2-O-β-d-
glucopyranoside (1), 11,21-dioxo-3β,15α,24-trihydroxyurs-12-ene-24-O-β-d-
glucopyranoside (2), and 11,21-dioxo-3β,15α,24-trihydroxyolean-12-ene-24-O-β-d-
glucopyranoside (3), and two new flavonoids, apigenin-7-O-[2′′-O-(5′′′-O-feruloyl)-β-d-
apiofuranosyl]-β-d-glucopyranoside (4) and chrysoeriol-7-O-[2′′-O-(5′′′-O-feruloyl)-β-d-
apiofuranosyl]-β-d-glucopyranoside (5), were isolated from the whole plant of fresh
celery (Apium graveolens), together with 10 known flavonoids. The structures of the new
compounds were elucidated by analysis of spectroscopic data. The inhibitory effects of
the compounds isolated on nitric oxide production in lipopolysaccaride-activated
macrophages were evaluated.