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ABSTRACT

Destiawan, Bayu. 2019. Effect of Lanang Onion Extract (Allium sativum L.)
against growth of Propionibacterium acnes In Vitro. Final Assignment,
Medical Faculty, University of Muhammadiyah Malang. Supervisor: (1)
Sri Adila Nurainiwati * (2) Pertiwi Febriana Candrawati **

Background: Acne vulgaris is a disease which many people have experienced.

Indonesia, in 2009 the incident has reached 90%. Treatment of Acne Vulgaris
with long-term antibiotics such as erythromycin and clindamycin in patients
often causes resistance. Lanang onion has a good effect as an antibacterial
because it contains allicin, so it can be used as an alternative therapy for Acne
Vulgaris.
Objective: To determine the effect of lanang onion extract (Allium sativum L.)
against growth of Propionibacterium acnes.
Method: True experimental with Post test Only Control Group Design.
Concentration of lanang onion extract were 100%, 50%, 25%, 12,5%, 6,25%,
3,125%, 1,56%, and 0,78% to determine Minimum Inhibitory Concetration
(MIC) and Minimum Bactericidal Concentration (MBC). Data were analyzed
using Kruskal Wallis test and Mann Whitney.
Result and Discussion: MIC were found at 6,25%. The results of Mann Whitney
test found significant differences start at 6,25% with the control group. MBC
were found at 50%. It showed the chemicals in lanang onion extract has
antibacterial effect.
Conclusion: There is effect of lanang onion extract against Propionibacterium
acnes growth.

Keywords: Lanang Onion, Propionibacterium acnes, Dillution, MIC, MBC.

*) Lecturer of Dermatology and Venereology, Medical Faculty, University of

Muhammadiyah Malang
**)) Lecturer of Pediatric, Medical Faculty, University of Muhammadiyah
Malang