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  • Blistering Disorders Table

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    Dylan Rasto
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    Pemphigus vulgaris causes flaccid blisters on the skin and mucous membranes due to loss of cell adhesion within the epidermis. Bullous pemphigoid causes tense blisters on the trunk and arms from separation between the epidermis and dermis due to antibodies against basement membrane zone proteins. Dermatitis herpetiformis causes a symmetric rash with vesicles on extensor surfaces associated with celiac disease, shown by IgA deposits in the dermal papillae.

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    Dermatology

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    Pemphigus vulgaris causes flaccid blisters on the skin and mucous membranes due to loss of cell adhesion within the epidermis. Bullous pemphigoid causes tense blisters on the trunk and arms from separation between the epidermis and dermis due to antibodies against basement membrane zone proteins. Dermatitis herpetiformis causes a symmetric rash with vesicles on extensor surfaces associated with celiac disease, shown by IgA deposits in the dermal papillae.

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    4 views1 page

    Blistering Disorders Table

    Uploaded by

    Dylan Rasto
    Pemphigus vulgaris causes flaccid blisters on the skin and mucous membranes due to loss of cell adhesion within the epidermis. Bullous pemphigoid causes tense blisters on the trunk and arms from separation between the epidermis and dermis due to antibodies against basement membrane zone proteins. Dermatitis herpetiformis causes a symmetric rash with vesicles on extensor surfaces associated with celiac disease, shown by IgA deposits in the dermal papillae.

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    of 1

    Blistering

    Disorders

    Pemphigus Vulgaris Bullous pemphigoid Dermatitis herpetiformis

    Organs skin skin skin
    Oral mucus membrane intestines (enteropathay/celiac disease)



    Lesion flaccid bullae wide spread tense bullae trunk arms vesicles figurate array (crown of jewels)
    Nikolsky sign symmetric distribution
    Extensor surfaces


    Histopath interepidermal vesicle subepidermal bullae subepidermal bullae
    Acantholysis eosinophils neutrophils


    DIF IgG epidermal cytoplasm IgG linear basement membrane zone IgA in dermal papillae (granular)
    Lesion chicken wire basement membrane zone


    IIF perilesional perilesional unaffected skin
    Intracellular linear basement membrane zone none


    Antigen desmoglein 3 BP 180 and BP130 transglutaminase 2
    Structure desmosome hemi desmosome none


    Treatment corticosteroids (oral) corticosteroids (topical) dietary change
    Dapsone

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