Eline Slagboom

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P. Eline Slagboom

Born January 14, 1960 (age 59)

Dordrecht, Netherlands

Residence Woubrugge

Nationality Dutch

Alma mater Leiden University

Scientific career
 Fields Molecular Epidemiology, human

genetics, ageing, longevity, complex

diseases, epigenetics

Institutions Leiden University Medical Center

Website www.molepi.nl

P. Eline Slagboom (born January 18, 1960, Dordrecht, The Netherlands) is

a Dutch biologist specializing in the human familial longevity and ageing.

Contents

 1Education
 2Career
 3Research
o 3.1Leiden Longevity study
o 3.2GARP study
 4Personal
 5References

Education[edit]
 High School: Christelijk Lyceum, Delft, 1978
 Bachelors: Leiden University in Biology, 1979
 Masters: Leiden University in Biology, 1985
 Ph.D.: Leiden University (thesis: Genomic Instability and Aging), 1993

Career[edit]
After receiving her Ph.D. Slagboom joined the Department of Vascular and Connective Tissues
Research at the Gaubius Laboratory, (TNO-PG, The Netherlands). As a post doc she initiated a unit
for genetic epidemiological studies aimed at the identification of genetic determinants of
multifactorial diseases. Slagboom started between 1995 and 1997 a genetic research line
on osteoarthritis (OA) including linkage studies in families with early onset OA, genetic association
studies in population cohorts and linkage studies in populations of affected sibling-pairs. From 1998
on, Slagboom, in collaboration with research groups at different universities, obtained various grants
that allowed initiation of a genotyping facility for genome scanning at the Netherlands Organisation
for Applied Scientific Research (TNO). In 2000, Slagboom was appointed as professor of molecular
epidemiology at the Leiden University Medical Center.[1] She established a new section of Molecular
Epidemiology and Genotyping Center at the department of Medical Statistics and Bioinformatics.
Slagboom has initiated a masterclass for Statistical Analysis of Genetic Data and Bioinformatics in
Genomic Research and is involved in various teaching activities.
Focus of the research in the past 10 years is on genomic, epigenetic and biomarker studies of
healthy/unhealthy ageing and familial longevity in humans. These studies
include genomics, metabolomics, and proteomics analysis of age-related disease. A diversity of
human cohorts with unique study designs is being analysed for this purpose. Slagboom is one of two
founders of the Research on Ageing at the Leiden University Medical Center, supported among
other foundations by the Netherlands Genomic Initiative. She initiated and heads the Leiden
Longevity Study (LLS) together with R.G.J. Westendorp and a research cohort
of osteoarthritis patients. The mission of her research group is the identification of genomic
factors, biomarkers, and functional mechanisms marking and contributing to complex diseases in
humans with a focus on ageing, longevity, and age-related disease. Slagboom has a leading role in
large consortia within ageing research such as the Netherlands Consortium on Healthy Ageing, in
which she established collaborative research with industry, and European Union large scale
collaborative research projects (Treat~OA, GEHA, and LIFESPAN).
Currently she heads a group of 15-20 scientists and academic staff has now started to obtain grants
for new research lines (functional genomic studies in osteoarthritis and studies into interaction
between genetic and epigenetic variation). She is PI of a new large scale collaborative FP7 project
(IDEAL: Integrated research on DEvelopmental determinants of Ageing and Longevity) together with
Bas Zwaan (Wageningen University and Research Centre; 2011–2016).[2]

Research[edit]
Leiden Longevity study[edit]
Slagboom has built a database of 420 families with long lived siblings (over 90 years of age) and
family members in The Netherlands, which has been used for many longevity studies. The siblings
and their families have undergone periodic testing over a period of decades, providing a mass of
longitudinal data for statistical analysis. A large number of participants have also provided blood,
skin fibroblast, PBMCs and urine samples for testing of DNA, RNA, and proteins. Her research has
primarily focused on better understanding the influence of heredity on complex diseases,
including cardiovascular diseases. This work is in collaboration with the Gerontology and Geriatics
department of the Leiden University Medical Center.
GARP study[edit]
Slagboom has built a database of 200 sibling pair both affected with osteoarthritis and non affected
partners in The Netherlands, which has been used for many osteoarthritis studies. The patients and
their partners have undergone periodic testing over a period of decades, providing a mass of
longitudinal data for statistical analysis. A large number of participants have also
provided blood and urine samples for testing of DNA, RNA and proteins. Her research has primarily
focused on better understanding the influence of heredity on complex diseases. This work is in
collaboration with the Reumatology department of the Leiden University Medical Center.

Personal[edit]
Currently Slagboom lives in Woubrugge. She is married to jazz musician Toon Roos [3] and together
they have a daughter and a son.

References[edit]
1. ^ http://www.lumc.nl/over-het-lumc/hoo/slagboom
2. ^ "IDEAL - FP7 projects - Human development and ageing - Medical Research - Health - Research -
European Commission". Ec.europa.eu. 2012-04-07. Retrieved 2012-09-06.
3. ^ http://www.toonroos.com/
 Categories:
 1960 births
 Living people
 People from Dordrecht
 Dutch biologists
 Leiden University alumni
 Leiden University faculty