Celine Veneria F.

Dela Cruz
Patient’s risk factors:
Advancing age (67 years old)
Male sex
Cigarette smoker
Hypertension
Hx ACS (2002)
Atherosclerotic Aorta

Inflammatory Activation Degenerative process Infiltration of leukocytes in

response to the
production of ECM
fragments
Loss of elastin in the medial
layer, mediated by VSMC

Compensatory fibrosis
leading to increased
collagen deposition

Destruction of all matrix Increased MMP/ TIMP

components Imbalance

Alteration of tensile
strength and ability of aorta Oxidative stress; Shear
to accommodate pulsatile Stress
stretch

Abdominal Aortic Aneurysm

- wall thinning
- focal dilatation