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Manipulating The Immune System For Therapeutic
Manipulating The Immune System For Therapeutic
Immunobiology:
The Immune System in Health & Disease
Sixth Edition
Chapter 14
Manipulation of the Immune Response
1
Mechanism of steroid action
2
Cyclosporin A and tacrolimus inhibit T-cell activation by interfering with
the serine/threonine-specific phosphatase calcineurin
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Cyclosporin A and tacrolimus inhibit lymphocyte and
some granulocyte responses
4
Natalizumab, a therapeutic anti-alpha4 integrin mAb
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Figure 14-8
for the treatment of MS and IBD
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Figure 14-8 part 2 of 2
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Tumor rejection antigens are specific to individual tumors
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Figure 14-10 part 2 of 2
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Tumor rejection antigens may arise by point mutations in self proteins,
which occur during the process of oncogenesis
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Tumors can escape immune surveillance in a variety of ways
10
Tumors that lose expression of all MHC class I molecules as a mechanism
of escape from immune surveillance are more susceptible to NK cell killing
11
Examples of tumor antigens that have been targeted by monoclonal
antibodies in therapeutic trials
12
Transfection of tumors with the gene for B7 or for GM-CSF enhances
tumor immunogenicity
13
Diseases for which effective vaccines are still needed
14
Viruses are traditionally attenuated by selecting for growth in nonhuman cells
15