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Drug Design and Synthesis-Tutorial 1
Drug Design and Synthesis-Tutorial 1
Drug Design and Synthesis-Tutorial 1
Tutorial 1
CH215
1. How long does it take (on average) to develop a new drug? Approximately how
much does it cost? How long does a patent on a new drug last?
must submit a successful New Drug Application (NDA). What information about the
3. Drugs may be active at mammalian and non-mammalian targets. (a) What two
types of cellular proteins account for the majority of human drug targets? (b) Give an
4. In what way has the chemical nature of top selling drugs (in gross sales) changed
6. List THREE technologies that are used to investigate the molecular basis of human
disease. For ONE of these technologies, explain how it is used in drug discovery and
7. Define the terms “assay” and “screen” in relation to the process of identifying
“hits” during drug discovery and give one example of each (4 marks).
8. (a) In relation to a drug screening cascade, define a lead compound.
metabolism actions:
10. Provide THREE differences between “drug-like” small molecules and biologic drug
compounds.
11. (a) Name FOUR properties a compound must have in order to go into lead
optimization
11 (b). Provide ONE reason which is NOT related to the properties you describe in (a)
12. Define “primary”, “secondary” and “tertiary” assay within a typical lead
13 c. Provide TWO factors that could affect the bioavailability of an orally administered drug.
14. Give TWO examples of what an ethical review panel must determine and approve prior
to submission of a project license application.