BACTERIAL DISEASES OF THE SIGNS AND SYMPTOMS PATHOGENS AND VIRULENCE PATHOGENESIS AND DIAGNOSIS, TREATMENT

URINARY SYSTEM FACTORS EPIDEMIOLOGY AND PREVENTION

BACTERIAL URINARY ➢ Patients with mild Enteric bacteria ❖ About 8 million cases of ❖ Urinalysis of patients
urethritis, cystitis, or - Gram negative bacteria UTIs are diagnosed with the signs and
TRACT INFECTION
prostatitis = no that are part of the annually in the United symptoms of UTIs =
symptoms or only slight intestinal microbiota states, mostly women. leukocytes,
fever, but most often - Most common cause of ❖ Patients with UTIs often erythrocytes, and the
involves frequent, urinary tract infections inoculate their own causative bacterium,
urgent and painful urethras by introducing usually E. coli
urination called dysuria Escherichia coli fecal bacteria ❖ Mild UTIs resolve on
• Urine may be cloudy - Causes about 70% of ❖ UTIs are more common their own without
and bloody and cases in females than males treatment, though
have a strong foul - Strains of it that infect • Female urethras antimicrobial drugs
odor the bladder have are shorter and such as
➢ Mental confusion, attachment fimbriae closer to the cephalosporins,
following spread of (sometimes called pili) anus sulfonamides, and
bacteria from the that bind specifically to ❖ At risk for UTIs = semisynthetic
urinary system into the epithelial cells lining the diabetics, nursing home penicillin, can prevent
blood (bacteremia), is urinary bladder patients, elderly men the spread of infection
frequently the only in - Using fimbriae, these who have trouble to the kidneys and
the elderly strains move into bladder emptying their bladders bloods
➢ Manifestation of lower cells by an unknown due to prostate ❖ Some cases of chronic
urinary tract infection = mechanism and from enlargement, patients cystitis require
disappear within 24 – 48 biofilm- like aggregations with urinary catheters, antimicrobial for six
hours, several months if within a bladder cell’s women who use months to two years
repeated or chronic cytosol diaphragms for birth ❖ Acute pyelonephritis =
infections may occur control and people who 10 – 14 days of
➢ Pyelonephritis Proteus and Klebsiella do not drink adequate antimicrobial drugs
• More serious - Bacteria from the fluids ❖ Intravenous
condition intestinal tract ❖ Young girls around age administration = when
• Triggers severe - Cause about 10% of UTIs three = UTIs are more infection is severe
abdominal flank common due to ❖ Wiping from front to
(side), back Pseudomonas and contamination during back after defection so
pain, fever Staphylococcus the toilet training as not to drag bacteria
higher than 39 C - Nonenteric bacteria ❖ Boys = UTIs are rare from the anus to the
(102 F) that - Occasionally cause UTIs except in cases of urethra
persists for urinary tract ❖ Surgery = repair
more than two E. coli and Pseudomonas abnormalities that anatomical
restrict the flow of urine abnormalities that
BUCAG, ROSANNA P
 days, chills, - Have flagella that can ❖ UTIs are more common restrict the flow of
reddened skin, propel the bacteria up in uncircumcised males urine
vomiting and the urinary tract than in circumcised ❖ Continual low doses of
fatigue males antimicrobials to
• Untreated prevent recurrent
patients = infections in at- risk
bacteria from infections
an infected ❖ Prevention = drinking
kidney may 2-4 liters of fluids per
enter the day (increase the
bloodstream; volume of urine and
the resulting cleansing action of
bacteremia, as urination), urinating
well as damage following sexual
to the kidneys intercourse (flush out
from the initial bacteria that may have
infection, can be been introduced to the
fatal. urethra), refraining
from vaginal douching
(eliminates normal,
protective microbiota),
using a form of birth
control other than
diaphragms
LEPTOSPIROSIS ➢ Abrupt fever, myalgia Leptospira interrogans ❖ Human develop ❖ Leptospira does not
o Zoonosis = disease (muscle pain), muscle - Thin (0.1 um diameter), leptospirosis 2- 26 days stain well with Gram
primarily seen in stiffness and headache aerobic pathogen is following direct contact stain; a specific
animals that spread to ➢ Half of patients = highly motile by means with the urine of antibody test revealing
humans nausea, vomiting and of two axial filaments, infected animals or with the presence of
o The causative agent diarrhea each of which is the spirochetes in spirochete in blood or
enters the body ➢ One – third of patients = anchored at one end animal – urine – urine specimens is the
though breaks in the dry cough - Over 200 strains of Gram contaminated streams, preferred method of
skin or mucous ➢ Rarely fatal, but when it - negative spirochete lakes, or moist soil, all diagnosis
membrane and is, mortality is due to - Normally lives in many the environments in ❖ Intravenous penicillin
spread to the urinary kidney and liver failure, wild and domestic which the organisms treats severe
system from the meningitis or animals = in particular, can remain viable for six infections
blood respiratory distress rats, racoons, foxes, weeks or more. ❖ Effective way to limit
dogs, horses, cattle, and ❖ Leptospira the spread of bacteria
pigs = refrain from wading
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 o Grows o Penetrate intact in, swimming in, or
asymptomatically mucous consuming water
in the kidney membranes or contaminated with
tubules enter though animal urine
- This spirochete can also invisible cuts or ❖ An effective vaccine is
survive in streams, rivers, abrasions in the available for live- stock
and lakes skin and pets
o Corkscrews its
❖ interrogans = end of way through
spirochete is hooked in a these tissues
manner reminiscent of a and then travels
question mark via bloodstream
❖ Leptospira = grow on special throughout the
media enriched with bovine body, including
serum albumin or rabbit the central
serum nervous system,
damaging cells
lining small
blood vessels
and triggering
fever and other
signs and
symptoms
o The bacteremia
resolves, and
the spirochetes
live only in the
kidneys
o As the disease
progresses, the
spirochetes are
excreted in
urine
❖ Most at risk = farmers,
ranchers, veterinarians,
butches, and people
whose recreation takes
them to potentially
contaminated water
BUCAG, ROSANNA P
 STREPTOCOCCAL ➢ Hypertension and low
urine output
ACUTE
• Urine contains
GLOMERULONEPHRITIS blood and
proteins
NONVENEREAL DISEASES OF SIGNS AND SYMPTOMS
THE REPRODUCTIVE SYSTEM
STAPHYLOCOCCAL ➢ Sudden – onset fever,
chills, vomiting, diarrhea,
TOXIC SHOCK
extremely low blood
SYNDROME pressure, mental
confusion and a severe
red rash
➢ Untreated TSS is fatal to
50% of patients when
their blood pressure falls
so low that the brain,
heart, and other vital
organs have an
inadequate supply of
oxygen = “shock”
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Group A Streptococcus
PATHOGENS AND
VIRULENCE FACTORS
• Staphylococcus = ❖ Strains of Staphylococcus
normally part of the skin
and mucous membrane
microbiota
Toxic Shock Syndrome toxins
o Exotoxins that is
produced by strains ❖ S. aureus grows on
of S. aureus that
cause STTS
o Soluble poisonous
toxins released from
cells
o Bind simultaneously ❖ Occurs in males and
to major
histocompatibility
complex II molecules
on antigen –
❖ The body does not
remove from circulation
antibodies bound to the
antigens of some strains
of group A
streptococcus
❖ Antibody – antigen
complexes accumulate
in the glomeruli of the
kidneys, triggering
inflammation of the
glomeruli and nephrons
❖ Young patients =
recover fully
❖ Progressive and
irreversible kidney
damage may occur in
adults
PATHOGENESIS AND DIAGNOSIS, TREATMENT
EPIDEMIOLOGY AND PREVENTION
❖ Diagnosis is through signs
produce toxic shock and symptoms,
syndrome toxic that particularly in
grows in the vagina or in menstruating women
wound, the toxin then is ❖ Culture of blood samples
absorbed into the blood grown colonies of S.
aureus
superabsorbent ❖ TSS is a medical
tampons, especially emergency
when a blood – soaked o Patients
tampon remain in place experiencing
for a prolonged period sudden onset of
fever or rash
females, but most cases particularly
have been identified in during
menstruating females menstruation or
following surgery

BACTERIAL VAGINOSIS ➢ Homogenous white
vaginal discharge with a
“fishy” odor
➢ Some itching and
irritation of the vaginal
opening
➢ 50% women report no
symptoms
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presenting cells and T ❖ At – risk individuals = should seek
cell receptors on T women who use immediate
cells tampons, vaginal treatment
o Bind to sites other sponges, or diaphragms, ❖ Treatment = removal of
than the normal newly delivered mothers, foreign material
antigen – binding surgery patients (tampon, sponge,
sites of these (especially after nasal diaphragm, nasal
immune system surgery), and anyone packing) and drainage of
molecules with an infection of S. infected wounds
o When a toxin aureus
molecule binds two
defensive cells
together, it activates
the T cell
o These activated T
cells release an
overabundance of
cytokines triggering
manifestations of TSS
• TSST -1 = 75% cases of
staphylococcal toxic
shock syndrome
Enterotoxins
o Exotoxins that cause
gastrointestinal
distress when
ingested
o 25% cases
• Normal lactobacilli of the ❖ A decline in the number ❖ Diagnose through signs
vaginas are replaced with of lactobacilli populating o Odor, discharge
a large number of the vagina results in a pH characteristics,
facultatively or obligate in the vagina higher than and vaginal pH
anaerobic bacteria such the normal 4.5 greater than 4.5
Gram positive o Promotes or ❖ Vaginal cells = clue cells;
Gardnerella vaginalis and allows the completely covered with
Mycoplasma hominis growth of the anaerobic bacteria
bacteria supports the diagnosis
❖ Oral metronidazole = 7
days

VAGINAL CANDIDIASIS ➢ White mucoid colonies Candida albicans
growing on mucous
membrane of the vagina
and the skin covering the
vaginal labia
➢ The yeast produces
severe vaginal itching
and burning, which
urination intensifies
➢ Sexual intercourse =
painful
➢ Vaginal discharge = curd-
like and slight
Candida spp.
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❖ Associated with having ❖ Vaginal metronidazole =
multiple sexual partners 5 days
and vaginal douching ❖ Sexual abstinence and
❖ Virgins are rarely refraining from douching
affected are beneficial
❖ Bacterial vaginosis not a
sexually transmitted
disease
C. albicans ❖ Stained preparations of
- most common o Lives in the vagina in vaginal discharge reveal
species causing competition with clusters of budding yeast
candidiasis lactobacilli and other and branching
- opportunistic bacteria pseudohyphae with
ascomycete yeast o Multiply rapidly correlated symptoms
- forms long cellular (following changes in ❖ Azole suppositories or
extensions called vaginal pH or cream or oral fluconazole
pseudo hyphae microbiota), ❖ Azole creams = oil –
o appear triggering based that weaken latex
similar to the inflammation and condoms
true hyphae other manifestations ❖ Maintain the normal
of o Transmitted between vaginal microbiota by
filamentous individuals (can pass avoiding excessive use of
fungi to babies during antibacterial drugs
- Candida changing childbirth and rarely ❖ Vaginal candidiasis is
from yeast form to to males during acquired rarely via sexual
filamentous form is a sexual contact contact
virulence factor ❖ Immunocompromised
o Virulence is individuals (especially
not due to AIDS patients) = can
formation of become systematic
pseudo ❖ 75% women = will
hyphae but experience candidiasis at
to the genes least once
themselves ❖ 50% = will have two or
more episodes
- Common members ❖ Predisposing factors =
of the microbiota of cancer, invasive hospital
the skin and mucous procedure, antibacterial
membrane treatments (which inhibit

❖
SEXUALLY TRANSMITTED ➢ Presence of lesions
DISEASES (STDs)
o also known as
venereal diseases
o Major epidemic has
developed over the
last 45 years
➢ Asymptomatic in younger
o 333 million new
women
cases occur each year
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- E.g. The digestive and normal bacteria that
reproductive tracts compete with Candida),
of 40% - 80% of all diabetes, severe burns,
healthy individuals intravenous drug abuse,
harbor the yeasts and AIDS
❖ 100% AIDS patient will
develop candidiasis in
their reproductive or
digestive tract
❖ Young people often ❖ Sexual abstinence or
• Known risk factor experiment with sex completely faithful
for the and many have an it – mutual monogamy
transmission of cannot- happen to me ❖ Latex or Polyurethane
HIV and condoms = reduce the
attitude, which leads
development of risk of contracting many
to exposing themselves
AIDS STDs, but they are not
to serious health risks perfectly safe
❖ Embarrassment over ❖ Diseases of the skin and
• These patients do contraction of an STD digestive system such as
not seek treatment can impair normal scabies infection,
• Suffer horrendous psychological giardiasis, shigellosis and
long -term development hepatitis can be
consequences transmitted sexually
concerning sexuality
including
development of ❖ Female adolescent = at
birth defects in the risk for STDs (cervical
babies, ectopic lining is especially
pregnancy prone to bacterial
(implantation of a
invasion
fetus outside the
❖ Sexually active 15-year-old
womb),
girl has a 12.5 % chance of
miscarriage,
developing Pelvic
sterility, or the
inflammatory disease
development of
(inflammation and pain in
cervical cancer
the uterus, uterine tubes, or
ovaries); whereas at age 24
the probability decrease to
1.25%
 SIGNS AND SYMPTOMS PATHOGENS AND VIRULENCE PATHOGENESIS AND DIAGNOSIS, TREATMENT
BACTERIAL STDs FACTORS EPIDEMIOLOGY AND PREVENTION
GONORRHEA ➢ Men Neisseria gonorrhoeae ❖ Gonococci adhere, via ❖ Presence of Gram –
o Sometimes called • Insufferably - Also known as the their fimbriae, and negative diplococci in
“clap” from the symptomatic gonococcus capsules to epithelial pus from an inflamed
archaic French word • Acute - Gram negative bacteria cells of the mucous penis = diagnosis of
clapoir, meaning inflammation usually forms pairs of cells membrane lining much symptomatic gonorrhea
brothel occurs 2-5 days that have fimbriae, of the genital, urinary, in men
o Excess of semen after infection polysaccharide capsules and digestive tracts of ❖ Genetic probes =
(“flow of seed” in in the urethra and a major cell wall humans diagnosis of
Greek) of penis, antigen called ❖ 100 pairs of cells can asymptomatic cases of
o Occurs in humans causing lipooligosaccharide cause disease gonorrhea in mean and
only extremely (composed of lipid A or ❖ The bacterium cannot women
o Most civilian cases painful endotoxin and sugar attach to cells lining the ❖ No long- term specific
occur in urination and a molecules) vagina; instead, the immunity against N.
adolescents, purulent (pus – - Cells that lack these three bacteria most gonorrhoeae and thus
particularly among filled) discharge structural features are commonly infect the peoples can have
those in several • Rarely, avirulent cervix of the uterus gonorrhea multiple
southeastern states bacterium - Cocci = protect ❖ N. gonorrhoeae times
who have multiple invades the themselves from the o Via fimbriae, o Highly variable
sexual partners prostate or immune system by they attach to surface antigens
o Infection is four epididymis, secreting enzyme that sperm cells, in this bacterium
times more where the cleaves secretory IgA in which allows o Immunity
common among formation of mucus bacterium to against one
blacks than scar tissue can hitchhike to the strain often
nonblack render the man uterine tubes provides no
o Slightly common infertile and beyond protection
among males than ➢ Women producing against other
females • Often pelvic strains
o An individual’s risk asymptomatic inflammatory ❖ Use of antimicrobial to
of infection • 50%-80% of disease prevent genital diseases
increases with infected women ❖ Chronic infections = may select for hardier
increasing have no scarring of the tubes, resistant strains,
frequency of sexual symptoms or no resulting in ectopic worsening the situation
encounters obvious signs of pregnancies or sterility ❖ Preventive strategies:
o Women = 50% infection for ❖ Gonococcal infections o Sexual
chance of infection years of organs outside the abstinence
during a single • Try to have a reproductive tracts also o Monogamy with
sexual encounter baby, damage occur a monogamous
partner
BUCAG, ROSANNA P
 with an infected to the uterine o A woman’s o 100% consistent
man tube becomes urethral and proper use
o Men = 20% chance obvious opening is close of condoms
of infection during a • 25% suffer to her vaginal
single sexual pelvic opening, which
encounter with an inflammatory the bacteria can
infected woman disease infect the
o Infection of older urethra during
children with N. sexual
gonorrhoeae is a intercourse
strong evidence of ❖ Anal intercourse can
sexual abuse by an lead to proctitis
adult (inflammation of the
rectum)
❖ Oral sexual intercourse
= infect the pharynx, or
gums (pharyngitis and
gingivitis)
o Commonly seen
in men who
have sex with
men
❖ Phagocytized bacteria
survive and multiply
within neutrophils,
traveling within these
leukocytes throughout
the body
❖ Rare cases = gonococci
travel to the joints,
meninges, or heart
(arthritis, meningitis,
endocarditis)
❖ Gonococcal infection of
child during birth can
result to inflammation
of the cornea,
ophthalmia
neonatorum (inflammation
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 of the conjunctiva in newborns)
or blindness

BUCAG, ROSANNA P
 SYPHILIS PRIMARY
o Afflicts more than Chancre
12 million new • small, painless,
victims each year reddened hard
lesion forms at the
o Remains endemic
site of infection 10-
among sex workers
21 days after
who have sex with
exposure
men and users of
illegal drugs • typically, from on
the external
genitalia
• 20% forms in the
mouth, around the
anus, or on the
fingers, lips or
nipples
• Often unobserved,
especially in
women, in whom
these lesions
frequently form on
the cervix
SECONDARY
➢ Sore throat, headache,
mild fever, malaise,
myalgia,
lymphadenopathy
(diseased lymph nodes),
and widespread rash
(palms and soles of the
feet)
➢ The rash does not itch
or hurt and persist for
months
LATENTS
➢ No symptoms
TERTIARY
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Treponema pallidum
- Helical cells of this
spirochete are so narrow
(0.1 um) that they are
difficult to see by regular
light microscopy in Gram
stained specimens
- Phase – contrast
microscopy, dark field –
microscopy, or special
stains are used to
increase contrast
- Lives naturally only in
humans
- Cannot survive in the
environment because it
can be destroyed by heat,
disinfectants, soaps,
drying, concentration of
oxygen in the air, and pH
- Have not be cultured in
cell – free media, though
they have coaxed it to
multiply in rabbits,
monkeys, and in rabbit
epithelial cell cultures
- It multiplies slowly (binary
fission occurs every 30
hours) and only for a few
generations
- Using recombinant DNA
technology, they inserted
genes from Treponema
into E. coli and isolated
some genes’ proteins
o These proteins
enable
Treponema to
T. pallidum
- Fastidious and
sensitive
- Obligate parasite of
humans ❖ MHA – TP
- Transmitted via
sexual contact,
during the early
stage of infection,
when the
spirochete are
numerous
- Can be spread from
mother to fetus and
rarely through
blood transfusion
- Cannot be spread
by fomites such as
toilet seats, eating, ❖ Spirochetes can be
utensils or clothing
- 10% - 30% = risk of
infection from a
single, unprotected
sexual contact with
and infected
partner
PRIMARY SYPHILIS
❖ Chancre forms at the
site of infection
❖ The center of chancre
fill with serum that is
extremely infectious
due to the presence of
spirochete
❖ Chancre remain for
three to six weeks and
then disappear without
scarring
❖ Specific antibody tests =
diagnosis of primary,
secondary, and
congenital syphilis
(microhemagglutination
assay against T.
pallidum) = uses red
blood cells that have
been artificially coated
with Treponema
antigens
= Antibodies in the
serum of infected
patients will agglutinate
(clump) the red blood
cells – positive test for
exposure of T. pallidum
observed in fresh
discharge from lesions,
but only when
microscopic
observations of clinical
samples are made
immediately
o Treponema
rarely survive
transport to a
laboratory
o Nonpathogenic
spirochetes,
which are
normal part of
the oral
microbiota, can
yield false
positive results,
so mouth can’t
 ➢ Some untreated
patients experience
dementia, blindness, - Hyaluronidase = enable
paralysis, heart failure,
or syphilitic gummas
➢ Gummas = rubbery, - Glycocalyx = protect it
swollen, lesions that
occur in bones, in
nervous tissues or on
the skin; rarely develops
in countries where
antimicrobial drugs are
available
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adhere to human SECONDARY SYPHILIS be tested for
cells ❖ Treponema has invaded syphilis
the bloodstream and ❖ Tertiary syphilis =
Treponema to infiltrate spread throughout the extremely difficult to
intracellular spaces body diagnose because any
❖ Rash lesions are filled spirochete present and
from phagocytosis by with spirochetes and because the signs and
leukocytes are extremely symptoms may occur
contagious years apart and seems
❖ People are infected unrelated to one
when fluid from the another
lesions enter breaks in ❖ Penicillin G = not
the skin effective for treating
❖ Nonsexual transmission tertiary syphilis because
is rare this phase is a
LATENT SYPHILIS hyperimmune response
❖ After several weeks or and not an active
months, the rash infection
gradually disappears
❖ Inactive stage of the
disease
❖ May last 10 or more
years
TERTIARY SYPHILIS
❖ Third of the originally
infected patients
❖ Not associated with the
direct effects of
Treponema, but rather
with severe
complications resulting
from inflammation and
a hyperimmune
response against the
pathogen
❖ Gummas, destruction of
cardiovascular or
central nervous system
tissue, personality
 changes, insanity, and
blindness
CONGENITAL SYPHILIS
❖ Results when the
bacteria crosses the
placenta from an
infected mother to her
fetus
❖ Death of the fetus =
transmission of the
fetus from a mother
experiencing primary or
secondary syphilis
❖ Mental retardation and
malformation of many
organs = transmission
of the fetus from a
mother latent syphilis
o Newborns with
latent infection
= widespread
rash like the
secondary
syphilis (2
years)

BUCAG, ROSANNA P
 CHLAMYDIAL ➢ 85% = Chlamydial Chlamydia ❖ C. trachomatis enters ❖ Specific fluorescent
genital tract infected - Non-motile the body through antibodies or nucleic
INFECTION
women are - Grow and multiply only abrasion or laceration acid probes
o Sexually transmitted
asymptomatic within the vesicles inside and infects cells of the ❖ PCR amplification
chlamydial infection are
➢ 75% = Shows signs and host cells conjunctiva or cells ❖ Surgical correction of
most prevalent among
symptoms similar to - Once considered to be lining a mucous eyelid deformities may
women under the age
those of gonorrhea viruses because of their membrane of the prevent the abrasion,
of 20 because they are
(urethritis, painful small size and obligate trachea, bronchi, scarring, and blindness
physiologically
urination, and pus intracellular parasite urethra, uterus, uterine ❖ Trachoma strains
susceptible to infection
discharge from the - Cellular and possess RNA, tubes, anus or rectum infecting the eyes of a
o LGV strains are
penis) DNA and functional 70S ❖ Typically, the lesion at a newborn are treated
primarily found in the
➢ Epididymitis = ribosomes site of infection is with erythromycin
tropics
inflammation of the - Two membrane, similar to overlooked because it is cream for 10-14 days
o Over 500 million people
epididymis; leads to those of a typical Gram – small, painless and
worldwide, particularly
sterility negative bacterium, heals rapidly
children, contract
➢ Orchitis = inflammation surround each chlamydial ❖ Headache, muscle pain,
ocular infection
of a testis; leads to cell, but there is no and fever may occur
• The bacterium
sterility peptidoglycan between ❖ 80% = infected people
infects children ➢ Trachoma = an eye the membrane have no symptoms
as they pass
disease that develops - Do not have cell walls ❖ Proctitis may occur in
through the
when babies are - Classified in the phylum men or women because
birth canal infected at birth; Chlamydiae of lymphatic spread of
• The pathogen leading cause of Chlamydia from the
may also be nontraumatic blindness Chlamydia trachomatis genitalia or urethra to
transmitted in humans worldwide - Very limited host range the rectum
from eye to eye ➢ Lymphogranuloma - All strains are pathogens ❖ 15% = Proctitis in
via droplets, o a severe form of of humans, infecting the homosexual men result
hands, chlamydial STD conjunctiva, lungs, urinary from the spread of the
contaminated o transient tract, or genital tract with bacteria via anal
fomites or flies genetical lesion one exceptional strain intercourse
o Chlamydial eye at the site of that may be classified as a ❖ LGV strains of
infections are endemic infection on the separate species Chlamydia infect the
in crowded, poor penis, urethra, - More than 10 strains lymph nodes in the
communities where scrotum, cause STDs in humans groin, producing
people have deficient vagina, cervix, o Three of these buboes
personal hygiene, or external called LGV strains ❖ Lymphogranuloma
inadequate sanitation female genitalia trigger venereum proceeds to
and inferior medical o Followed by a lymphogranuloma a third stage
care development of venereum characterized by genital
BUCAG, ROSANNA P
 bubo = a o Other strains sores, constriction of
painfully cause Trachoma the urethra, and severe
inflamed lymph Chlamydia genital swelling
node in the - Unique developmental o Arthritis may
groin, and cycle involving two also occur
fever, chills, cellular morphologies, particularly in
anorexia, and both of which occur young white
muscle pain within the phagosome of males for an
o Buboes may a host cell unknown
enlarge to the - Elementary bodies reason
point that they o Tiny cocci (0.2 – ❖ Pelvic inflammatory
rupture and 0.4 mm) cocci disease = destruction of
producing o Infective forms infected cells at the site
draining sores o Relatively of infection and from
dormant the inflammatory
o Resistant to response this
environmental destruction stimulates
extremes and can ❖ Reinfection in the same
survive outside site by the same or a
cells similar strain triggers a
- Reticulate bodies vigorous hypersensitive
o Large (0.6 – 1.5 immune response that
mm) pleomorphic can result in blindness,
o Obligate sterility, or sexual
intracellular dysfunction
forms that are ❖ Trachoma strains
reproductive multiply in cells of the
rather than conjunctiva, killing
infective them and triggering a
LIFE CYCLE copious, purulent
1. EB attaches to a host cell discharge that causes
and triggers endocytosis the conjunctiva to
2. Once inside the vesicle, become scarred
EB converts into an RB o Scarring =
3. RB rapidly divides to form patients’ eyelid
many RBs to turn inward,
4. After 21 hours after making the
infection, RBs within the eyelashes
vesicle, which is now abrade, irritate
BUCAG, ROSANNA P
 called an inclusion body, and scar the
begin by converting back cornea
to EBs o Triggers
5. After 19 hours, the EBs invasion of
are released from the blood vessels
host cell via exocytosis into this
6. It can now infect new normally clear
cells and completing the surface of the
life cycle eyes
o Scarred cornea
= becomes
filled with
blood vessels
and is no longer
transparent
o All results to
blindness

BUCAG, ROSANNA P
BUCAG, ROSANNA P