Professional Documents
Culture Documents
Metronidazol 500 MG
Metronidazol 500 MG
J. A. K. LAW0
Department of Pharmaceutics
and Pharmaceutical Wcrobiology
Ahmadu Bello University
Zaria, Nigeria.
For personal use only.
ABSTRACT
In-vitro d i s s o l u t i o n tests were c a r r i e d out with
t a b l e t s prepared from d i f f e r e n t p a r t i c l e s i z e ranges
o f metronidazole. Influence of t a b l e t binding agents
(Methylcellulose, polyvinyl pyrrolidone - (FVP) ,
potato starch and g e l a t i n ) on the drug release were
i n v e s t i g a t e d under s i m i l a r conditions, Comprimates
containing PVP and drug with p a r t i c l e size 1.75 lun ( i n
l a c t o s e mixture) gave optimum r e s u l t s These findings
mY open new Ways of formulating a metronidazole
t a b l e t e x h i b i t i n g improved drug - liberation, subse-
quently with a better b i o a v a i l a b i l i t y than the K L X d -
Tablet manufactured i n Hungary,
1085
Copyright 0 1984 by Marcel Dekker, Inc. 0363-90451841 1007-1085 $3.5010
1086 LAUWO
INTRODUCTION
EXPERIMENTAL
Materials
Me tronidazole (Richter-Budapes t) USP- standard,
potato starch, corn starch (Agena Austria),
Gelatina Alba (Rousselot - Paris), Polyvinyl
EFFECT OF PARTICLE SIZE. I1 1087
Methods:
Tablet - Formulatioe
Drug Dev Ind Pharm Downloaded from informahealthcare.com by McMaster University on 02/06/15
Metronidazole 250.0
Aerosil 1.5
Magn. s t e a r . 1.5
Tablet binder 7.5
Talc 10.0
Corn s t a r c h 79.5
-s m -
0
3
a
0
0
w
I
5 15 30 120 150
DISSOLUTION TIME Imin)
FIGURE 1
E f f e c t o f Particle Size on t h e Dissolution Rate o f Metronidozole from
Tablets w i t h.- Key: A = 400-500 urn; B = 125-20wm;
C = 1.75um. Vertical lines represent Rel. S.Dev. for 9 similar
experiments.
Drug Dev Ind Pharm Downloaded from informahealthcare.com by McMaster University on 02/06/15
For personal use only.
m
H
N
M
H
H
5 15 30 60 90 120 I50
DISSOLUTIQN TIME Imin)
FIGURE 2
. .
E f f e c t of Particle Size on the Dissolution Rate o f Metronidazole from
Tablets w i t h 2% Methylcellulose Binder. Key: A = 400-5OOum;
-
f: = 125-2OOurn; C = 1.75um.
Drug Dev Ind Pharm Downloaded from informahealthcare.com by McMaster University on 02/06/15
For personal use only.
V
5 15 30 90 I20 150
FIGURE 3
E f f e c t o f Particle Size on r o l u t i o n Rate of bhtronidazole
from T a b l e t s w i t h 24’. Potato Starch Binder. Key: A = hOe5wurn;
-
B = 125-200 urn; C = 1.75 Mm.
Drug Dev Ind Pharm Downloaded from informahealthcare.com by McMaster University on 02/06/15
H
9
m
H
N
M
For personal use only.
H
H
5 15 30 60 90 120 150
DISSO\UTION TIME Imn)
-
FIGURE 4
E f f e c t o f Particle Size on t h e Dissolution Rate o f M s t r o n i d a z o l e from
Tablets w i t h 2% PVP 0Binder. Key: A = 400-500 urn; I3 s 125-200um;
C = 1.75 ym.
Drug Dev Ind Pharm Downloaded from informahealthcare.com by McMaster University on 02/06/15
For personal use only.
5 1s r, 60 sb 120 150
DISSOLUTION TIME lminl
FIGURE 5
Comparative Influence o f Binders on the Release o f Metronidazole
from Tablets, Key: A = Methylcellulose B = Potato Starch;
C = Gelatin; D = PVP. Content of Each Binder was 2% (W/W),
Particle Size o f Metronidazole was 1.75um i n each o f t h e Formulafions.
EFFECT OF PARTICLE S I Z E . I1 1095
ACKNOWLEDGEMENTS
Thanks t o t h e Chemical Works of Cedeon Richter
Ltd., Budapest f o r supplying m a t e r i a l s and equipment.
Grateful thanks t o the l a t e Prof, G q w r m a t i , L, (+),
Faculty of Pharm, Sci., University o f Medicine,
Budapest, D r . H, Gyozo and t o D r , I. Kolbe f o r t h e i r
f r i e n d l y encouragement and advice i n t h i s work. Many
thanks t o M r s . J. Brzezina, Dept. of C i v i l Eng., A,B.U,
Zaria, f o r designing t h e f i g u r e s ,
REFERENCES
1. K, Munzel, Pharm. Acta Helv., 46, 513-538 (1971.
1096 LAW0
118 (1974).