Liver and biliary system

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1. All of the following are features of congenital hepatic fibrosis in
domestic animals, EXCEPT:
Hypoplastic portal veins
Tortuous bile ducts
Nodular regeneration with inflammation
Extensive portal bridging fibrosis
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2. Which of the following is FALSE?
Caroli disease / non-obstructive saccular dilatation of the biliary tree
von Meyenburg complexes / extensive portal bridging fibrosis with tortuous
bile ducts
Adult polycystic disease / multiple random cysts without connection with the
biliary tree
Congenital hepatic fibrosis / defective remodeling of the ductal plates
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3. Which canine breeds are most commonly affected by primary portal
vein hypoplasia?
West Highland White terrier and Yorkshire
Yorkshire and Cairn terrier
Dalmatian and Bedlington terrier
Rottweiler and French bulldog
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4. In congenital portosystemic vascular anomalies, there can be portal
hypertension leading to ascites.

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5. Portal hypertension and ascites can be a feature of all the following
conditions, EXCEPT:
 Primary portal vein hypoplasia
End-stage hepatic fibrosis
Congenital portosystemic vascular anomaly
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6. Tissue from a ponie:

Most likely expected clinical pathology finding:

Increased HDL
Decreased LDL
Increased lipoproteins
Increased VLDL
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7. All of the following are findings of canine primary idiopathic
hyperlipidemia, EXCEPT:
Fasting lipemia
Increased plasma VLDL
Chylous effusion
 Hyperchylomicronemia
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8. Rift Valley fever virus and canine adenovirus-1 are viral exceptions
that cause centrilobular hepatocellular necrosis.

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9. All of the following can cause necrosis of hepatic sinusoidal lining cells,
EXCEPT:
Sporidesmin
Acetaminophen
Microcystin-LR
Ischemia-reperfusion injury
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10. Destructive cholangitis is usually caused by:
Pyrrolizidine alkaloid
Blue green algae
Idiosyncratic drug-induced damage
Immune-mediated inflammation with piecemeal necrosis
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11. Which markers can be used for detection of ductular reaction / bile
duct hyperplasia?
p63 and calponin
CK7 and CK 19
Vimentin and Ki-67
CK 8 and CK18
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12. Overt cirrhotic nodular changes are not very common in domestic
animals other than the dog.

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13. Tissue from a dog:

Possible cause:
Chronic hepatitis
Chronic cholangitis
Chronic toxicity
All of the above
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14. Tissues from a dog:
All of the following can be associated with this condition, EXCEPT:
Glucagonoma
Idiopathic vacuolar hepatopathy
Increased plasma amino acid concentrations
Gastric carcinoma
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15. Tissue from a dog with crusty lesions on pawpads:
Which of the following is NOT an expected histologic finding?
Bridging portal fibrosis
Vacuolar hepatopathy
Parenchymal collapse
Nodular regeneration
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16. Which of the following is NOT a feature of hepatic veno-occlusive
disease?
Sinusoidal damage
Perivenular fibrosis
Obliteration of small intrahepatic veins
 Portal hypertension
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17. Hepatic veno-occlusive disease can be caused by all of the following,
EXCEPT:
Radiation therapy
Senecio jacobae (ragwort)
Hypericin in St. John's wort
Chemotherapy
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18. Chronic hepatitis is staged by assessing the degree of fibrosis.

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19. Which of the following is INCORRECT about hepatic copper
metabolism?
Impaired Cu biliary excretion can be a result of COMMD1 mutation in
Bedlington terriers
Accumulation of Cu in primary metabolic disorders is centrilobular
Accumulation of Cu in secondary hepatic dysfunction is periportal to irregular
Accumulation of Cu in excessive dietary intake is periportal
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20. Fine dissection of the liver parenchyma by reticulin or fine collagen
fibers into individual and small groups of hepatocytes is a feature of:
Copper-associated chronic hepatitis
Hepatocutaneous syndrome
Chronic hepatitis of Doberman Pinschers
Lobular dissecting hepatitis
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21. Tissue from a newborn foal:

Neonatal infection with EHV-1

Maternal intoxication with hairy vetch
 Maternal leptospirosis
Maternal pyrrolizidine alkaloid toxicity
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22. Which of the following can be a predisposing factor for gallbladder
infarction in dogs?
Reflux of bacteria from the intestinal tract
Hyperlipidemia
Pancreatitis
None of the above
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23. All of the following are features of Wesselsbron disease, EXCEPT:
Can cause outbreaks of abortion and perinatal death of sheep
Vector-borne disease caused by a Flavivirus
There is random hepatic necrosis, intranuclear eosinophilic inclusions,
lymphocyte necrosis with lymphoblastic stimulation in lymphoid organs
Adults are severely affected, manifesting jaundice and hepatitis
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24. All are features of Rift Valley fever, EXCEPT:
Arthropod-borne Phlebovirus infection
Causes mortality in young animals and abortion
Periportal necrosis with elongated eosinophilic intranuclear inclusions
Can cause widespread hemorrhage
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25. Which of the following has been associated with Theiler's disease /
equine serum hepatitis?
Pegivirus
Arenovirus
Iltovirus
Coronavirus
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26. Black disease (necrotic hepatitis) in sheep is caused by:
 Clostridium hemolyticum
Clostridium novyi
Clostridium septicum
Clostridium perfringens
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27. All of the following are examples of Dicrocoelid flukes, EXCEPT:
Platynosomum spp.
Eurythrema pancreaticum
Fascioloides magna
Dicrocoelium spp.
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28. Cervids are tolerant definitive hosts of Fascioloides magna

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29. What is the injury mechanism caused by microcystin-LR toxin
secreted by Microcystis aeruginosa?
Inhibition of hepatocellular protein synthesis
Ligation and blockage of ATPase synthase
Disorganization of hepatocyte and endothelial cytoskeletal actin filaments
Alkylating agent causing megalocytosis and nuclear hyperchromasia
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30. Which of the following is INCORRECT about toxic hepatic injury in
domestic animals?
Cycas spp / macrozamin / alkylating agent
Xanthium strumarium / atractyloside / ATP depletion / mitochondrial-
mediated cell death
Amanita spp / BMAA / gastroenteritis
Cyanobacteria / mycrocystin-LR / cytoskeletal disruption
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31. Which of the following, apart from hepatic injury, can also be
neurotoxic causing Wallerian degeneration in cattle?
 Cycadales
Xanthium spp
Amanitins
Halogenate hydrocarbons
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32. Which species are quite resistant to aflatoxin B1?
Dogs and sheep
Cats and horses
Horses and poultry
sheep and cattle
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33. Fuminisin B1 is involved in all of these conditions, EXCEPT:
Hepatocellular carcinoma in laboratory rats
Renal tubular necrosis in sheep
Leukoencephalomalacia in horses
Pulmonary edema in pigs
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34. In fumonisin B1 toxicity, which of the following is accumulated
leading to impaired membrane function?
Ceramide
Sphingosine
Phosphatidylserine
Sphinganine
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35.
Most likely causative agent?
Phomopsin A
Bicyclic octapeptides
Sporidesmin
Pyrrolizidine alkaloid
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36. Tissue from a sheep:
Most likely cause?
Helium spp.
Lupinus spp.
Panicum spp.
Xanthium spp.
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37. Sheep are one of the most susceptible species to pyrrolizidine
alkaloid toxicity.

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38. Increased dietary levels of molybdenum and vitamin E can cause
copper toxicosis.

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39. Dogs with ____________ have higher incidence of gallbladder mucocele:
Hyperadrenocorticism
Hypothyroidism
Addison's disease
Hyperinsulinemia
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40. Tissue from a dog:

This can be an incidental finding in which other species?

Nondomestic felids
Sheep
Cervids
Bears
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41. Hepatocellular tumors can be common in:
Cats
Pot-bellied pigs
White-tailed deer
 Beavers
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42. Paraneoplastic hypoglycemia has been well characterized with:
Cholangiocellular carcinoma
Nephroblastoma
Meningioma
Hepatocellular carcinoma
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43. Hepatoblastomas are most commonly seen in:
Piglets
Foals
Kittens
Calves
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44. Best marker for hepatoblastoma:
HepPar1
PGP 9.5
Alpha fetoprotein
Brachyury
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45. Which of the following are best markers for mixed hepatocellular and
cholangiocellular carcinomas?
CK18 and Alpha fetoprotein
HepPar1 and AE1/AE3
CK 7 and HepPar1
Calponin and p63
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46. Emperipolesis is a feature of:
Hepatocytotropic lymphoma
Hepatosplenic lymphoma
 Mast cell leukemia
Extramedullary plasma cell tumor
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47. Name this condition:

Pautrier's microabscess
Cellular cannibalism
Emperipolesis
Councilman bodies
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48. All are features of hepatosplenic lymphoma, EXCEPT:
T cells / CD3+ / CD11-
Poor prognosis
Neoplastic lymphocytes mostly within sinusoids
Erythrophagocytosis can be seen
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