Microbial Chemotherapy

1.Which bacterium is devoid of a cell wall?

a) Shigella
b) Heamophilus
c) Mycoplasma
d) Chlamydia

2. Bacteria cell walls are composed of what repeat units?

a) Proteoglycans
b) Pepitoglycans
c) Polysaccharides
d) Plasmin

3. Inhibitor of bacterial cell wall formation:

a) Vancomycin
b) Erythromycin
c) Clindamycin
d) Streptomycin

Use the following answers for Ques 4-8

a) Inhibitors of bacterial cell wall formation

b) Agents which interfere with cell membrane permeability
c) Inhibitors of 50s & 30s function: Protein synthesis
d) Inhibitors of Protein synthesis: Protease inhibitors
e) Antimetabolites
f) Inhibitors of nucleic acid formation and function

4. What is the MOA of Zidovudine?

5. What is the MOA of Cephalosporins?

6. What is the MOA of Tetracycline?

7. What is the MOA of Saquinavir ?

8. What is the MOA of Nystatin?

9. COTRIMOXAZOLE is a fixed combination of __________and trimethoprim (5:1)

a) SULFACETAMIDE
b) SILVER SULFADIAZINE
c) SULFADOXINE
d) SULPHAMETHOXAZOLE

10.Pencillins are bacteriocidal True or False

11.All of the following Penicillins are resistant to staphylococcal Beta-lactamase

EXCEPT:

a) AMOXICILLIN
b) METHICILLIN
c) NAFCILLIN
d) OXACILLIN

12. Which of the following competes with Penicillins at tubular secretory site of
kidney therefore prolonging its effectiveness?

a) Clavulanic acid
b) Probenecid
c) Nalidixic acid
d) Ofloxacin

13. What group of antimicrobials is indicated for use in soft skin and tissue
infections?

a) Pencilllins
b) Quinolones
c) Anti- metabolites
d) Cephalosporins
14. MOA: inhibition of DNA gyrase

a) Pencilllins
b) Quinolones
c) Anti- metabolites
d) Cephalosporins

15. Clinical application: syphilis

a) Pencilllins
b) Quinolones
c) Anti- metabolites
d) Cephalosporins

16. Clinical application: Prostatitis (Good accumulation in tissues)

a) Pencilllins
b) Quinolones
c) Anti- metabolites
d) Cephalosporins

17. All of the following are aminoglycosides EXCEPT:

a) AMIKACIN
b) TOBRAMYCIN
c) VANCOMYCIN
d) GENTAMICIN

18. CLINICAL APPLICATIONS: Extensively used genital infections including

chlamydia, cholera, Rickettsia, Acne (Propionibacterium) Pelvic inflammatory
diseases, Respiratory TI

a) Tetracyclines
b) Aminoglycosides
c) Sulphonamides
d) Macrolides
48. Which does not have an effect on cell wall synthesis

a. penicillin

b. oxacillin

c. rifampicin

d. vancomycin

49. Which drug is given with levamisol to treat colon cancer

a. cyclophosphamide

b. ondansetron

c. 5 fluorouracil

d. methotrexate

50. which is penicillinase resistant

a. benzyl penicillin G

b. amoxicillin

c. ampicillin

d. nafacillin

51.Which is not a Betalactam

a. penicillin

b. streptomycin

c. cefalexin

d. cefuroxime
63.Which does not affect cell wall synthesis

a. cycloserine

b. bacitracin

c. vancomycin

d. polymixin