Professional Documents
Culture Documents
Alvarez 2015
Alvarez 2015
Acupuncture
Leilani Alvarez
HISTORY
Acupuncture has been practiced for over 4000 years in China and other
Asian countries. Western cultures rejected acupuncture for many centuries
because of discordance with medical knowledge at the time that seemed to
contradict philosophical and metaphoric theories of acupuncture. It is only
with our more current understanding of neurophysiology that acupuncture
has gained acceptance in the Western world. Acupuncture was introduced to
the United States in the 1950s but gained popular interest in the 1970s when
diplomatic relations with the People’s Republic of China improved.1 The
International Veterinary Acupuncture Society was formed in 1974 and
has been training veterinarians in acupuncture ever since, along with other
organizations.
Traditional Chinese veterinary medicine (TCVM), which encompasses
acupuncture, herbal medicine, and other disciplines, states that disease is
caused by an imbalance of energy. When the body is balanced (understood
as homeostasis in conventional medicine) health is achieved. There are two
principle approaches in TCVM acupuncture: the Eight Principles approach,
which is a derivation of yin-yang, and the Five Elements approach.2 Unim-
peded flow of qi (loosely translated as life force or energy) through channels
or pathways, called meridians, is essential for health. Acupuncture points
along these meridians have specific physiologic functions. Point prescriptions
365
366 PART THREE Application of Concepts and Therapy
can be used to address particular painful regions (Table 18-1). There are
more than 360 documented acupuncture points in the body, with more than
150 points identified in companion animal medicine. Each point has a spe-
cific anatomic location and characteristic effects (see Appendix 1). Acupunc-
ture was studied classically in humans and horses. Acupuncture points in
dogs, cats, and other species are transpositional points, in which comparative
anatomy was used to identify their location.
CHAPTER 18 Acupuncture 367
EVIDENCE-BASED MEDICINE
Critically reviewed, well-designed studies are largely lacking in the field of
veterinary complementary and alternative medicine. As the popularity of
acupuncture has grown in human medicine, so has the interest in judicious
scientific research to support its efficacy. Several recent randomized con-
trolled trials (RCTs) in humans have demonstrated the effectiveness of acu-
puncture for specific painful conditions.3–5
There is a growing body of evidence for the use of acupuncture as a com-
plementary treatment modality in companion animals. Often the challenges
in reporting valid data with regard to acupuncture involve studies with too
few subjects, subjective parameters, absence of appropriate blinding, and
difficult-to-replicate treatment protocols.6 There is also the challenge of
an appropriate control group, as sham acupuncture has multiple physiologic
effects and does not accurately represent a control group.7
Human Evidence
Several Cochrane reviews have demonstrated the effectiveness of acupuncture
for a wide variety of painful conditions.4 A systematic review of 29 human
RCTs involving acupuncture for the relief of chronic pain conditions including
chronic headaches and back, neck, shoulder, and osteoarthritic pain found that
acupuncture was superior to sham and no acupuncture control groups.3 A sys-
tematic review of knee osteoarthritis also found that acupuncture was superior
to sham acupuncture and standard treatment.8 Similarly, a Cochrane system-
atic review of 16 RCTs involving nearly 3500 patients with peripheral joint
osteoarthritis showed that patients receiving acupuncture had statistically sig-
nificant benefits over sham control groups; however, the authors concluded
that the benefits were small and likely a result of a placebo effect.9 A systematic
review in 2010, however, concluded that acupuncture is more effective than
placebo for chronically occurring painful conditions.5
Veterinary Evidence
In a recent randomized controlled clinical trial, dogs that received electroa-
cupuncture (EA) were less likely to require rescue analgesia than dogs receiv-
ing sham acupuncture or morphine alone.10
In another small study, dogs receiving EA had significantly elevated b-
endorphin levels 1 and 3 hours after elective ovariohysterectomy, and effects
of analgesia persisted at least 24 hours.11 In a study comparing 80 paraplegic dogs
with thoracolumbar disk herniation that did not undergo surgery, dogs receiving
EA and steroids had a faster and higher return to ambulation, reduced back pain,
and reduced relapse incidence compared with dogs receiving prednisone alone.12
In a controlled clinical trial, dogs undergoing hemilaminectomy for acute
disk herniation that received EA in addition to conventional analgesics
368 PART THREE Application of Concepts and Therapy
MECHANISM OF ACTION
The effects of acupuncture on body systems are vast and complex, and
involve multiple pathways that influence the neurologic, musculoskeletal,
endocrine, cardiovascular, and immune systems. The focus in this section will
be on the pain-relieving and analgesic effects of acupuncture.17–20
Anatomy of Acupoints
Acupuncture points are distinct loci in the body that are known to cause spe-
cific physiologic effects. They are shallow depressions in the body, typically
overlying borders between muscles, tendons, or bones. There has been no
definitive evidence demonstrating that acupuncture points (or acupoints)
are specific anatomic entities. Many points, however, correlate with known
anatomic structures, such as motor end points, and may be classified according
to their association with neural structures.21 Histologically, many acupoints
are associated with larger accumulations of mast cells, nerve bundles and plex-
uses, capillaries, venules, and lymphatics as compared with surrounding tis-
sues.17 For example, several acupoints along the bladder meridian
correspond to branches of the median cutaneous nerve as it enters the dermis
along the thoracolumbar spine (Figure 18-2). Acupoints are also known to
have lower electrical impedance than surrounding tissues. For this reason,
hand-held electric point finders are used for locating and stimulating acupoints.
Finally, many acupoints correlate with known trigger point locations.22
Local Effects
• Tissue trauma leading to local inflammatory effects including stimulation
of the coagulation cascade and release of inflammatory mediators includ-
ing prostaglandins, leukotrienes, bradykinin, and platelet activating factor
(Figure 18-3)
• Release of histamine, heparin, and kinin protease from mast cells, leading
to vasodilation
• Stimulation of nociceptive afferent sensory nerve fibers Ad (group III)
and C (group IV)
• Release of trigger points
CHAPTER 18 Acupuncture 369
FIGURE 18-2 Cutaneous nerve entering the dermis at an acupuncture point along the bladder
meridian. (From Schoen AM: Veterinary acupuncture: ancient art to modern medicine, ed 2,
St Louis, 2001, Mosby.)
Neural Mechanisms
Peripheral Nervous System
Nociceptors respond to the noxious mechanical stimulation of needle inser-
tion by transmitting sharp pain (pinprick) sensations via thinly myelinated
small diameter Ad afferent nerve fibers and aching or burning pain via unmy-
elinated slower-conducting C polymodal fibers (see Figure 18-3). These set
off inhibitory pathways along with Ab afferent stimulation from percutane-
ous stimulation that block further pain transmission to the brain, as
explained by the gate-control theory (see Chapter 3).
Opiates
Thal
Hypo
PAG
Efferent
HPA
RN
ACTH
Cortisol
5-HT STT
Anti-inflammatory SRT
SG ⫺
A␦
C
Afferent
Tissue Acupuncture
trauma needle
FIGURE 18-3 Acupuncture mechanism of action. When an acupuncture needle pierces the skin, it
causes micro tissue trauma, setting off the coagulation cascade and releasing multiple anti-
inflammatory mediators. Nociceptive afferent nerves, Ad (fast conducting) and C polymodal (slow
conducting), send signals to the dorsal horn of the spinal cord, synapsing and traveling via the
spinothalamic tract (STT) and the spinoreticular tract (SRT), respectively, to the thalamus (Thal). The
periaqueductal gray (PAG) and Thal release opiate peptides in response to ascending nociceptive
pathways. Efferent nerves from the prefrontal cortex synapse at the hypothalamus (Hypo) and
project down the PAG and nucleus raphe (RN), releasing inhibitory mediators serotonin (5-HT) and
monoamines. These stimulate the substantia gelatinosa (SG) region of the dorsal horn of the spinal
cord to release enkephalin or dynorphin and inhibit transmission of nociceptive fibers. (Key: ACTH,
Adrenocorticotropic hormone; HPA, hypothalamic-pituitary-adrenal axis.)
ACUPUNCTURE ANALGESIA
EA may be used effectively to induce analgesia during surgical procedures
and postoperatively to reduce the dosage and frequency of pharmaceutical
drug administration (Figure 18-4). Effects are thought to result primarily
from descending inhibitory pathways. Low-frequency high-intensity EA (2
to 20 Hz) is opioid peptide mediated and has a cumulative effect. High fre-
quency EA (80 to 200 Hz) induces the sympathoadrenal medullary axis,
leading to release of serotonin, epinephrine, and norepinephrine, and is non-
cumulative.22,25 In addition, EA can effectively control neuropathic pain by
disinhibiting central sensitization and wind-up pain.26,27
Acupuncture analgesia may be inhibited via the following19,22:
• Administration of naloxone for low-frequency EA
• Administration of drugs that block serotonergic receptors
• Local anesthetics injected at the site of acupuncture needle insertion
• Needle insertion in areas of segmental nerve damage
BL 23
BL 40
GB 34 LI 11
ST 36
SP 6
BL 60 PC 6
TH 5
LI 4
Bo Ko Ku
In Ko Ten
FORMS OF ACUPUNCTURE
Dry Needle
A sterile acupuncture needle is inserted into a known acupuncture location.
Needles may be stainless steel or silicone coated and may come in individual
packages or in bundles of 5 or 10 needle packs (Figure 18-5). A wide variety of
needles is available and range in size from 28 to 36 gauge (which is less than
a millimeter) and ½ inch to 2 inches long for small animals, and 20 to 32 gauge,
½ inch to 3½ inches long for large animals (Figure 18-6).
Aquapuncture
In aquapuncture, sterile solution is injected into acupuncture points via
large-gauge hypodermic needles (typically 25 gauge) to provide prolonged
stimulation to the point. The point is distended with the solution and swells
the point, providing a more subtle but longer-lasting type of stimulation to
the acupoint. Effects are likely to last as long as it takes the body to resorb the
solution, in many cases up to 24 hours (Figure 18-7).
CHAPTER 18 Acupuncture 373
FIGURE 18-5 Examples of acupuncture needles. Acupuncture needles may be stainless steel (left)
or silicone coated (right) and may come in bulk packages (left) or individually packaged (right).
A B
FIGURE 18-6 Acupuncture needle sizes.
Electroacupuncture
Electrical leads are attached to stainless steel acupuncture needles that are
already in place, and an electric current is applied to provide increased stim-
ulation to the acupuncture points. The current (direct or alternating), fre-
quency (Hz), mode (continuous, intermittent, dispense or disperse), and
amplitude are set according to the specific condition being treated. Electro-
acupuncture (EA) affords a longer-lasting treatment than dry-needle treat-
ment alone and can provide profound analgesic effects (Figure 18-8).
acupoint or applied to the needle for secondary warming. Care must be used
to avoid overheating or burning the skin surface.
Acupressure
Digital pressure is applied to the acupoint to stimulate the area. Pressure
should be applied for several minutes to each point. Effects are generally
shorter lasting than with other methods.
Implantation
Gold beads or other sterile products may be implanted at the site of acu-
points for permanent stimulation. Prospective, double-blind clinical trials
in veterinary medicine have failed to demonstrate the benefit of gold wire
or gold bead implantation for the treatment of canine hip dysplasia.29,30
ACUPUNCTURE TRAINING
Acupuncture on animals should be practiced by qualified veterinarians who
have successfully completed training and acquired certification. Veterinary
CHAPTER 18 Acupuncture 377
CONCLUSION
In a world of rapidly developing pharmaceutical drugs for pain management,
an animal may be subjected to medications that have been used for less than a
decade. The medication may lack formal study in the species receiving the
medication, and often the drug interactions and side effects are significant
or poorly understood. In contrast, acupuncture embodies thousands of years
of safe and effective use, and a growing number of evidence-based studies
support its use. Acupuncture should be part of a multimodal pain manage-
ment program standard for all veterinary patients.
REFERENCES
1. Schoen AM. Veterinary acupuncture: Ancient art to modern medicine, ed 2, St. Louis,
2001, Mosby.
2. Maciocia G. The foundations of Chinese medicine: A comprehensive text for acupuncturists
and herbalists, ed 2, London, 2005, Churchill Livingstone.
378 PART THREE Application of Concepts and Therapy
3. Vickers AJ, Cronin AM, Maschino AC, et al. Acupuncture for chronic pain: Individual
patient data meta-analysis. Arch Intern Med. 172:1444–1453, 2012.
4. Lee MS, Ernst E. Acupuncture for pain: An overview of Cochrane reviews. Chin J Integr
Med. 17:187–189, 2011.
5. Hopton A, MacPherson H. Acupuncture for chronic pain: Is acupuncture more than an
effective placebo? A systematic review of pooled data from meta-analyses. Pain Pract.
10:94–102, 2010.
6. Filshie J, White A. Medical Acupuncture: A Western scientific approach, London, 1998,
Churchill Livingstone.
7. Maciocia G. The practice of Chinese medicine: The treatment of diseases with acupuncture
and Chinese herbs, ed 2, 2008, Churchill Livingstone.
8. Cao L, Zhang XL, Gao YS, Jiang Y. Needle acupuncture for osteoarthritis of the knee.
A systematic review and updated meta-analysis. Saudi Med J. 33:526–532, 2012.
9. Manheimer E, Cheng K, Linde K, et al. Acupuncture for peripheral joint osteoarthritis.
Cochrane Database Syst Rev: Art. No. CD001977.
10. Gakiya HH, Silva DA, Gomes J, et al. Electroacupuncture versus morphine for the
postoperative control pain in dogs. Acta Cir Bras. 26:346–351, 2011.
11. Groppetti D, Pecile AM, Sacerdote P, et al. Effectiveness of electroacupuncture analgesia
compared with opioid administration in a dog model: A pilot study. Br J Anaesth
107:612–618, 2011.
12. Han HJ, Yoon HY, Kim JY, et al. Clinical effect of additional electroacupuncture on
thoracolumbar intervertebral disc herniation in 80 paraplegic dogs. Am J Chin Med.
38:1015–1025, 2010.
13. Laim A, Jaggy A, Forterre F, et al. Effects of adjunct electroacupuncture on severity
of postoperative pain in dogs undergoing hemilaminectomy because of acute
thoracolumbar intervertebral disk disease. J Am Vet Med Assoc. 234:1141–1146, 2009.
14. Joaquim JG, Luna SP, Brondani JT, et al. Comparison of decompressive surgery,
electroacupuncture, and decompressive surgery followed by electroacupuncture for the
treatment of dogs with intervertebral disk disease with long-standing severe deficits. J Am
Vet Med Assoc. 236:1225–1229, 2010.
15. Hayashi AM, Matera JM, Fonseca Pinto AC. Evaluation of electroacupuncture
treatment for thoracolumbar intervertebral disk disease in dogs. J Am Vet Med Assoc.
231:913–918, 2007.
16. Arlt S, Heuwieser W. Evidence-based complementary and alternative veterinary
medicine—a contradiction in terms? Berl Munch Tierarztl Wochenschr. 123:377–384,
2010.
17. Steiss JE. The neurophysiologic basis of acupuncture. In: Schoen AM, editor: Veterinary
acupuncture: Ancient art to modern medicine, ed 2, St. Louis, 2001, Mosby.
18. Kendall DE. Parts I and II. A scientific model of acupuncture. Am J Acupunct.
17:251–268, 343–360, 1989.
19. Bowsher D. Mechanisms of acupuncture. In Filshie J and White A, editor: Medical
acupuncture: A Western scientific approach, New York, 2006, Churchill Livingstone.
20. Ma YT, Ma M, Cho ZH. Biomedical acupuncture for pain management: An integrative
approach, Philadelphia, 2005, Elsevier.
21. Gunn CC. Acupuncture loci: A proposal for their classification according to their
relationship to known neural structures. Am J Clin Med. 4:183–195, 1976.
22. Baldry PE. Acupuncture, trigger points and musculoskeletal pain. Brookline, 2000,
Churchill Livingstone.
23. Chiu JH, Cheng HC, Tai CH, et al. Electroacupuncture-induced neural activation detected
by use of manganese-enhanced functional magnetic resonance imaging in rabbits. Am J Vet
Res. 62:178–182, 2001.
CHAPTER 18 Acupuncture 379
24. Li H, Wang YP. Effect of auricular acupuncture on gastrointestinal motility and its
relationship with vagal activity. Acupunct Med. 31:57–64, 2013.
25. Gaynor JS, Klide AM. Acupuncture for surgical analgesia and postoperative analgesia.
In Schoen AM, editor: Veterinary acupuncture: Ancient art to modern medicine, ed 2, St.
Louis, 2001, Mosby.
26. Tian S, Wang XY, Ding GH. Repeated electro-acupuncture attenuates chronic visceral
hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat irritable bowel
syndrome model. Life Sci. 83:356–363, 2008.
27. Cantwell SL. Traditional Chinese veterinary medicine: The mechanism and management of
acupuncture for chronic pain. Top Companion Animal Med. 25:53–58, 2010.
28. Dommerholt J, Huijbregts PA: Myofascial trigger points, pathophysiology and
evidence-informed diagnosis and management, Sudbury, Mass., 2011, Jones and Bartlett
Publishers.
29. Hielm-Bjorkman A, Raekallio M, Kuusela E, et al: Double-blind evaluation of implants of
gold wire at acupuncture points in the dog as a treatment for osteoarthritis induced by hip
dysplasia. Vet Rec. 149:452–456, 2001.
30. Bolliger C, DeCamp CE, Stajich M, et al: Gait analysis of dogs with hip dysplasia treated with
gold bead implantation acupuncture. Vet Comp Orthop Traumatol. 15:116–122, 2002.
31. Xie H, Preast V: Traditional Chinese veterinary medicine: Fundamental principles, 2005,
Jing Tang.
380 PART THREE Application of Concepts and Therapy
Continued
382 PART THREE Application of Concepts and Therapy