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  • AIM: TO STUDY VARIOUS TYPES OF MODELS (First Order, Zero Order, Higuchi, Hixon Crowel and Peppas) by Given Experimental Data

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    1) The document studies various kinetic models including zero order, first order, Higuchi, Hixon-Crowell and Peppas models to analyze drug release data over time. 2) Drug release percentages at different time points are provided and plotted against time and its various transformations to determine the best fitting model. 3) Linear regression analysis is used to determine the coefficient of determination (R2) and validate the models based on their R2 values.

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    1) The document studies various kinetic models including zero order, first order, Higuchi, Hixon-Crowell and Peppas models to analyze drug release data over time. 2) Drug release percentages at different time points are provided and plotted against time and its various transformations to determine the best fitting model. 3) Linear regression analysis is used to determine the coefficient of determination (R2) and validate the models based on their R2 values.

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    © All Rights Reserved
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    9 views6 pages

    AIM: TO STUDY VARIOUS TYPES OF MODELS (First Order, Zero Order, Higuchi, Hixon Crowel and Peppas) by Given Experimental Data

    Uploaded by

    anon_564512531
    1) The document studies various kinetic models including zero order, first order, Higuchi, Hixon-Crowell and Peppas models to analyze drug release data over time. 2) Drug release percentages at different time points are provided and plotted against time and its various transformations to determine the best fitting model. 3) Linear regression analysis is used to determine the coefficient of determination (R2) and validate the models based on their R2 values.

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as xlsx, pdf, or txt
    of 6

    AIM: TO STUDY VARIOUS TYPES OF MODELS( First order,Zero order,Higuchi,Hixon crowel and Pepp

    TIME % RELEASE(Q) LOG%RELEASE SQ. ROOT OF TIME CUBE ROOT OF TIME


    30 10.6 1.025 5.477 3.107
    60 13.74 1.137 7.745 3.914
    120 16.29 1.211 10.954 4.932
    180 21.17 1.325 13.416 5.646
    240 23.69 1.374 15.491 6.214
    300 26.77 1.427 17.32 6.694
    360 29.36 1.467 18.973 7.113

    zero order

    35

    30
    f(x) = 0.0561350331x + 9.8865439093
    R² = 0.9884898353
    25

    20
    Column B
    15 Linear (Column B)

    10

    0
    0 50 100 150 200 250 300 350 400

    FIRST ORDER 35
    LOG T % RELEASE(Q)
    30
    1.477 10.6
    1.778 13.74 25 f(x) = 17.0598039485x - 16.3399168645
    R² = 0.9404362317
    2.079 16.29 20
    2.255 21.17 Colum
    15 Linear
    2.38 23.69
    2.477 26.77 10
    2.56 29.36 5

    0
    1.4 1.6 1.8 2 2.2 2.4 2.6 2.8

    FIRST ORDER
    400
    350
    f(x) = - 3246.306077422x + 6351.8035033764
    300 R² = 0.9922844922
    400
    LOG 100-Q TIME
    1.951 30 350
    f(x) = - 3246.306077422x + 6351.8035033764
    1.935 60 300 R² = 0.9922844922
    1.922 120
    250
    1.896 180
    1.882 240 200 Colum
    1.864 300 Linear
    150
    1.849 360
    100
    50
    0
    1.84 1.86 1.88 1.9 1.92 1.94 1.96

    HIGUCHI

    SQ. ROOT OF TIME % RELEASE(Q) 35


    5.477 10.6
    30
    7.745 13.74 f(x) = 1.3877579678x + 2.5125348386
    10.954 16.29 25 R² = 0.989924423
    13.416 21.17
    20
    15.491 23.69 Column B
    17.32 26.77 15 Linear (Colum
    18.973 29.36
    10

    0
    4 6 8 10 12 14 16 18 20

    HIXSONCROWEL

    CUBE ROOT OF TIME % RELEASE(Q)


    35
    3.107 10.6
    3.914 13.74 30
    4.932 16.29 25
    f(x) = 4.6663364019x - 4.8467964911
    R² = 0.9791813767
    5.646 21.17
    6.214 23.69 20 Column B
    6.694 26.77 Linear (Col
    15
    Column C
    7.113 29.36
    10

    0
    2.5 3 3.5 4 4.5 5 5.5 6 6.5 7 7.5
    PEPPAS

    LOG T LOG%RELEASE 1.6


    1.477 1.025 1.4 f(x) = 0.4072929558x + 0.4077374151
    1.778 1.137 1.2 R² = 0.9837711605
    2.079 1.211
    1
    2.255 1.325
    2.38 1.374 0.8 Column B
    2.477 1.427 Linear (Co
    0.6
    2.56 1.467 0.4
    0.2
    0
    1.4 1.6 1.8 2 2.2 2.4 2.6 2.8
    iguchi,Hixon crowel and Peppas) by given experimental Data

    LOG T 100-Q LOG 100-Q


    1.477 89.4 1.951
    1.778 86.26 1.935
    2.079 83.71 1.922
    2.255 78.83 1.896
    2.38 76.31 1.882
    2.477 73.23 1.864
    2.56 70.64 1.849

    nB
    (Column B)

    16.3399168645

    Column B
    Linear (Column B)

    2.2 2.4 2.6 2.8

    422x + 6351.8035033764
    422x + 6351.8035033764

    Column B
    Linear (Column B)

    1.92 1.94 1.96

    125348386

    Column B
    Linear (Column B)

    16 18 20

    9x - 4.8467964911

    Column B
    Linear (Column B)
    Column C

    5.5 6 6.5 7 7.5


    0.4077374151

    Column B
    Linear (Column B)

    2 2.4 2.6 2.8

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