CEMEX

Advanced Centre for Research-

Development in Experimental
Medicine
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2016 PRESENT

CEMEX
Physiopharmacologic
CSTD – Center for

Cellular&Integrative
Central Laboratory
of Enzymology and

Therapy of Pain

Excellence Center
CLTD – Central
Laboratory for
Drug Testing
Pharmacology

Study and
Biochemical

al Research
for
 IN VIVO INTEGRATIVE STUDIES UNIT CELLULAR AND MOLECULAR
FUNCTIONAL STUDIES UNIT
Animal Quarantine and Hosting Surgical Procedures for
Small and Large Animals Molecular analysis laboratory

Small animal Large animal radiology Small animals PET-MRI

ultrasound laboratory laboratory laboratory

Cellular Imaging Laboratory Physiopharmacology Laboratory

RESEARCH TOPICS
CANCER
FOCUS on:

! in vitro and in vivo screening

for new compounds or agents
for cancer therapy

! investigation of new combined

treatments to overcome MDR or
to improve the chemotherapy
outcomes

Alexa-Stratulat T. et al., What sustains the multidrug resistance phenotype beyond ABC efflux
transporters? Looking beyond the tip of the iceberg, Drug Resistance Updates 2019, 46, 100643
RESEARCH TOPICS
CARDIOVASCULAR
FOCUS on:

! cardiovascular and neuroscience

research

! continous telemetric acquisition

of arterial pressure, cardiac
electrical activity and autonomic
nervous system

! investigation of systemic and renal

hemodynamic mechanisms in
obesity-related kidney injury

Siriopol, D. et al., Arterial stiffness mediates the effect of salt intake on systolic blood
pressure, Journal of Clinical Hypertension, 20(11), 2018, p. 1587-1594

Lohmeier, T.E. et al., Chronic interactions between carotid baroreceptors and

chemoreceptors in obesity hypertension, Hypertension, 68(1), 2016, p. 227-235
RESEARCH TOPICS
NANOTECHNOLOGIES
FOCUS on:

! design and optimization of

multifunctional radiolabeled hybrid
magnetic nanoparticles

! nanoparticles for cancer diagnostic

and therapy

! non-viral vectors for gene transfer

and delivery

! magnetic nanoparticles – drug

formulation

G. Dodi et al., Hexagonal-shaped aminosilane magnetite nanoparticles: Preparation, characterization

and hybrid film deposition, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018,
542: 21-30

G. Dodi et al., Carboxymethyl guar gum nanoparticles for drug delivery applications: Preparation and
preliminary in-vitro investigations, Materials Science and Engineering C, 2016, 63: 628-636
RESEARCH TOPICS
PAIN
FOCUS on:

! molecular and integrative

mechanisms of peripheral and
central nociception

! investigation of the way how

antinociceptive substances or
some non-pharmacological
methods influence the molecular
and integrative mechanisms of
peripheral and central
nociception

Tamba B. et al., 2015. Enhanced analgesic effects of tramadol and common trace element
coadministration in mice: Coadministration of Tramadol and Trace Elements in Mice. Journal of
Neuroscience Research 93, 2015,1534–1541

Luca A et al. In-vivo safety and efficacy evaluation of a novel polymeric based lidocaine
formulation for topical analgesia. FARMACIA, 2019, 67(1)
RESEARCH TOPICS
DRUG DEVELOPMENT
FOCUS on:

! identification of molecular and

physio-pharmacological
integrative mechanisms of drug-
acting substances

! pharmacokinetics and
pharmacodynamics of drug-
acting substances

! toxicology and teratology for

medicines, medical devices and
biotechnologies
Balan V.
V et al.,
al Vibrational spectroscopy fingerprinting in medicine:
medicine from molecular to clinical
practice, Materials 2019, 12(18), 2884

R. Stefanescu et al., Contributions of mass spectrometry to the identification of low molecular

weight molecules able to reduce the toxicity of amyloid- peptide to cell cultures and transgenic
mouse models of Alzheimer's disease. Molecules. 2019: 24(6), 1167
RESEARCH TOPICS
EXPERIMENTAL SURGERY

FOCUS on:

! microsurgery

! wound healing, burns and

regenerative medicine

! drug testing

! medical devices evaluation

FUTURE DIRECTIONS

! New approaches in cancer therapy using different metallic or polymeric nano-entities

! 3D in vitro models and organoids development
! New animal models for old disease
! New painkillers
! 3D printing
! Biocompatible magnetic nanoparticles to enhance NMR contrast
! Development of an integrated Terahertz fingerprint database for biological material and chemical
compounds
! New PET/SPECT radiotracers based on polymer coated nanoparticles for targeted in vivo imaging
CEMEX in numbers
Over 35 research projects and contracts*
Over 70 published articles*
2,000m2 working surface
15 laboratories
t 5,000 small animals
Up to
14 permanent staff
32 associated researchers
over 60 students

* data for 2015 - 2019

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