CAUSES OF HAEMOPHILIA

1. In hemophilia, the blood does not clot as it should. Hemophilia is

normally an inherited
2. It happens because of a defect in one of the clotting factor genes on the
X chromosome.

3. Hemophilia tends to occur in males, since the gene can be passed from
mother to son.

4. Males typically lack a second X chromosome so they are unable to

make up for the defective gene. Most females have XX sex chromosomes
while most males have XY sex chromosomes.

5. Females may be carriers of hemophilia, but they are unlikely to have

the disorder. For a girl to have hemophilia, she must have the abnormal
gene on both of her X chromosomes, and this is very rare.

6. Sometimes, hemophilia is acquired because of a spontaneous genetic

mutation.

7. The disorder can also develop if the body forms antibodies to clotting
factors in the blood that then stop the clotting factors from working.