Drug name Indication Dosage Mechanism of Adverse reactions Contraindications Nursing implications

action
Generic name: Relief signs and 200mg tab Inhibits the CNS: headache, Severe hepatic Assessment & Drug Effects
Celecoxib symptoms of 1 tab every 12 enzyme COX-2. dizziness, impairment;  Therapeutic effectiveness is
osteoarthritis, hours for pain This enzyme is insomnia hypersensitivity to indicated by relief of joint
Brand name: rheumatoid required for the CV: edema celecoxib; pain.
Celebrex arthritis, synthesis of GI: bleeding, asthmatic patients  Lab tests: Periodically
ankylosing prostaglandins. abdominal pain, with aspirin triad; monitor Hct and Hgb, liver
Classification: spondylitis, and Have analgesics, diarhea, nausea advanced renal functions, BUN and
antirheumatics, juvenile arthritis. anti- Derma: disease; creatinine, and serum
NSAID’s inflammatory, and exfoliative concurrent use of electrolytes.
antipyretic dermatitis, steven- diuretics and ACE  Monitor closely lithium
Pregnancy properties. johnson inhibitors; levels when the two drugs are
category C Therapeutic syndrome, toxic anemia; given concurrently.
Effects: epidermal pregnancy  Monitor for fluid retention
Decreased pain necrolysis, rash. (category D) in and edema especially in those
and inflammation third trimester; with a history of hypertension
caused by arthritis lactation. or CHF.
or spondylitis. Patient & Family Education
Decreased  Promptly report any of the
number of following: unexplained
colorectal polyps. weight gain, edema, skin
Decreased pain. rash.
 Stop taking celecoxib and
promptly report to physician
if any of the following
occurs: S&S of liver
dysfunction including nausea,
fatigue, lethargy, itching,
jaundice, abdominal pain,
and flulike symptoms; S&S
of GI ulceration including
black, tarry stools and upper
GI distress.