Professional Documents
Culture Documents
Broch BIOSTAT-B SBI1513-e PDF
Broch BIOSTAT-B SBI1513-e PDF
Applications Industries
– Process development – Biopharmaceuticals
and optimization – Vaccines
– Scale-up and scaledown – Cell therapies
studies – Industrial biotechnology
– Seed expansion – Basic research
– Cell bank production – Education
– Protein supply
Configurable Design
Contact your Sartorius representative
and configure your BIOSTAT® B bioreactor
solution matching your specific needs.
Benefit from our flexible and scalable
options.
Reliable Quality
Every BIOSTAT® B is thoroughly tested
before it leaves our production facilities in
Germany. Benefit from our global service
and application specialist network for
professional installation and training.
UniVessel® Glass
Our proven autoclavable borosilicate
glass culture vessel is available in four
different volumes: 1 L, 2 L, 5 L and 10 L,
for all kinds of cell culture and microbial
applications.
Benefits
−− Classic stirred-tank design simplifies
your scale-up and scale-down studies
−− Extensive performance and
engineering data package available
−− Save additional investment and use
our special design for small autoclaves
UniVessel® SU
Our single-use 2 L stirred tank vessel
for cell culture applications combines
scalable design with all benefits of
disposable solutions. No more worries
about challenging timelines, workload
or cross-contamination. Get started
within minutes.
Benefits
−− Fully single-use vessel, DO and
pH sensors
−− Proven, scalable stirred tank design
−− Connection kit to upgrade existing
bioreactor controllers
BIOSTAT® B –
The Universal Controller
for Your Lab
Main Applications
−− Mammalian, insect, microbial and plant cell culture
−− Process development, optimization, characterization
−− Seed and small scale production
−− Protein supply
Main Applications
−− Mammalian, insect and plant cell culture
−− Process development, optimization, characterization
−− Seed and small scale production
−− Production of cell banks
Watch Video:
www.sartorius.com/ video-biostat-b
Main Applications
−− Mammalian, insect, plant and low density
microbial culture
−− Seed and small scale production
−− Protein supply
−− Stem cell expansion and production
RM Rocker
Our proven wave-mixed bioreactor consists of a rocker unit with
bag holder and pillow-shaped Flexsafe RM single-use bags for
culture volumes from 100 mL to 25 L. Use it as basic system or in
combination with the BIOSTAT® B control tower and single-use
optical pH and DO sensors to enable advanced control strategies
for batch, fed-batch and continuous perfusion.
Benefits
−− Optimized film formula, traceability of
raw materials and control of the entire
Flexsafe RM bag manufacturing process
assure excellent and consistent cell
growth of the most sensitive cell lines
−− Space-saving, individual control of two
RM bags on the same rocker platform
−− Easy-to-use rocker with advanced alarms
and safety features for reliable cultivation
12” Touch Screen
with closed frame; protected
against water splashes and
dust deposits. Easy-to-use and
reliable operation of your
BIOSTAT® B due to intuitive
design of human-machine
interface and advanced touch-
screen technology – even while
wearing laboratory gloves.
Control Tower
The control tower contains
both the aeration, pump and
temperature control modules,
saving valuable bench space in
your lab.
BIOSTAT® B
Configurable Flexibility
Single | Twin Control Tower
One BIOSTAT® B control tower can control up to two vessels completely
independently to save valuable lab space. Select culture vessel types
and volumes from our range of options, e.g. glass vessel, single-use vessel
or wave-mixed Flexsafe® RM bags.
Connections for
Sensors and External
Accessories
Quick-connect couplings make
it easy to attach all cables and
supplies to the culture vessels.
All connections are clearly
marked with the same names
used on the rear control tower
panel and in the local control
software menu for fast, error
proof identification.
Storage Tray
A storage tray for accessories
helps you organize your
workplace.
Aeration Strategies
A series of flexible aeration options turns the BIOSTAT® B into a multi-
talented bioreactor for a wide range of different applications, including
high-cell density microbial fermentation requiring considerable amounts
of oxygen to high-cell density cell culture applications requiring removal
of excessive carbon dioxide.
Microbial Applications
in Combination with UniVessel® Glass
N2
CO2
CO2
The intuitive touch screen on the control tower is used to locally operate the BIOSTAT® B:
Overview
of process
parameters
Pump
module
Automatic DO Control
Besides classic DO cascade control, we
have developed the unique advanced DO
controller that gives you more flexibility
to develop and optimize your DO control
strategy.
Automatic pH Control
Control the pH of your culture by auto- CO2
Base Acid
matic acid and base addition or by CO2
aeration and base addition. If you want
to use your BIOSTAT® B for both microbial
and cell culture you can configure your
bioreactor system with a combined acid
control via CO2 aeration and acid addition.
BioPAT® MFCS – SCADA Process Control
BioPAT® MFCS is a multi-functional supervisory control and data acquisition software,
specifically developed for bioprocessing applications in upstream and downstream.
Every BIOSTAT® bioreactor comes with basic data recording functionality of our BioPAT®
MFCS. Rely on more than 7,000 installations worldwide and over 25 years of experience.
BioPAT® MFCS | win
In addition to providing a genuine SCADA system for conventional and single-use
bioprocess applications, the optional advanced version of BioPAT® MFCS includes
a series of add-on modules:
– Bioprocess optimization with Design – Flexible device connection facility
of Experiments module (DoE) through OPC
– Automation with recipes according to – Expanded data recording and data
ANSI | ISA-88.01 archiving capabilities
– 21 CFR, Part 11 compatibility – Alarm recording and transmission
– Secure integration into company to multimedia devices
networks
Our Mission Is Your Productivity
We are well aware of how important smooth-running equipment is for effective process
development and efficient production. That is why we at Sartorius offer you a broad range
of preventive technical service, repair and application specialist support. Our ISO certified
quality management system ensures that you receive equipment and services that meet
the strictest quality requirements. Become one of our many customers who benefit from
our local presence worldwide, highly qualified specialists and well-versed technicians.
Control System
Advanced DO controller
Flexible switching CO2 from sparger to headspace
Software for dual use MO | CC
Mass flow controller
Antifoam control via sensor
Mechanical foam destroyer (MO applications)
Level control via sensor
Weight measurement substrates | culture vessel
Gravimetric feed | level control
Substrate addition via time profile
Redox (ORP) measurement
Turbidity measurement
BioPAT® Xgas O2 | CO2 off-gas analysis
System IQ | OQ
BioPAT® MFCS SCADA system
UniVessel® Glass
Double-wall culture vessel
Magnetic coupling for drive motor
STT connectors for safe inoculation and media transfer
Cooling finger (single-wall culture vessels)
Spin filter for perfusion mode
Aeration basket for organisms sensitive to shear stress
Rushton impellers | 3-blade segment impellers
Baffles
Bottle holder
Adapter for height reduction of exhaust cooler for the autoclave
Inoculation port
3-way addition port
Universal adapter ID 3.2 mm
Harvest pipe bent for complete draining
Port adapter 19 mm – 12 mm
Set of consumables
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