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SRK/T: Development of The Intraocular Lens Implant Power Calculation Formula
SRK/T: Development of The Intraocular Lens Implant Power Calculation Formula
John A. Retzlaff, M.D., Donald R. Sanders, M.D., Ph.D., Manus C. Kraff, M.D.
B TRA T
A ne, implant power calculation formula ( RKlT) .. as d eloped
u in the nonlin ar terms of the theOl'etical formulas a .it foundation
but empirical r gr ssion methodolog for optimization. Po toperati e
anterior chambel' depth prediction I'etinal thicknes a ial length
correction and corneal refracti e inde. .. ere tematieall and
interacti el optimized usin an iterati e p.-oce 's on fi e data ets
con. i ting
· of 1 677 post riOl' chamber lens ca e . The ne\ RKIT
fOl'mula perfOl'med ·Ii htl better than the Hollada RK II
Binkhorst and Hoffel' formula ,hieh wa. the e pected re ult a .an
fOl'mula pe.-forms supel"iorl ' \ ith the data f.-om, hich it wa deri ed,
omparati e accurae of thi. fOI"mula upon independent data set i
addl'e ed in a fo])ow-up report. The fOl'mula deri ed pro ide a
primal'il theoretical app.-oach undel' the R umbrella of formula
and has the added ad antage of bing calculable u ing either RK
-con tant that ha e been empirica]) deri ed 0 er the last nine
eal' or u in antel'iol" chamber depth e timate ,
Regression-derived lens implant power formulas that were empirically derived and individualized by
have an excellent accuracy record,l,8 Still, theoreti- manufacturers and surgeons over the last nine years.
cal formulas, because they are based on physiologic Many surgeons have expressed a desire to com-
optics, may be more accurate than regression for- pare regression formula results with theoretical
mulas when extended past a given database as in formula results for a given case and, if possible, have
unusually long or short eyes. some sort of definitive correlation between the
In addition to proven accuracy, regression for- regression A-constants and the theoretical anterior
mulas are simpler to derive and Vlanipulate than chamber depth (ACD) determinations. We decided,
theoretical formulas. 9 Residual error, due to sur- therefore, that it would be valuable to offer a
geon technique or intraocular lens (IOL) design, is theoretical approach to implant power calculation
combined into a single constant. In the SRK and under the SRK umbrella of formulas. We sought to
SRK II formulas, there are existing A-constants merge the theoretical and empirical approaches,
From the Department of Ophthalmology, University of Illinois at Chicago, and Medford, Oregon.
Analysis of the data performed in part by the Center for Clinical Research, which is funded by the American Society of Cataract and
Refractive Surgery and private donations.
Repdnt requests to Donald R. Sanders, M.D., Ph.D., 815 West Van Buren Street, Suite 300, Chicago, Illinois 60607.
HOFFER
6.5
6.0
5.5
0
u 5.0 HOLLADAY
« Fig. 1. (Retzlaff) Graph showing post-
0
w 4.5 operative ACDs predicted by
f- BINKHORST II different formulas for different
U 4.0
0 length eyes for an IOL with an
W ACD-constant of 4.0. The kera-
0:::
a...
3.5 tometry value of 43 D was used
3.0 for SRKfT and Holladay calcula-
tions.
2.5
2.0
19 22 25 28 31 34 37
AXIAL LENGTH
Computation of Offset and the Patient's Predicted Axial Length Correction Factor for Retinal
Postoperative ACD. The ACD-constant (ACDconst) Thickness
for a specific style IOL is the ACD of that IOL in an Many workers have theorized that physiologic
average eye. The difference between the average optical axial length is greater than ultrasonically
eye calculated iris plane and the AC D-constan t is the measured axial length by the distance from the
offset value for that IOL: vitreoretinal interface to the center retinal ele-
offset = ACDconst - 3.336 ments l (i.e., retinal thickness) (Figure 4).
Values from 0 to 0.5 mm have been used for the
The offset computed in this manner includes the
retinal thickness correction factor by various au-
corneal thickness dimension.
thors.I The Binkhorst formula uses 0.25 mm, the
In our data, the more complex linear form
Hoffer formula uses 0, and the Holladay formula
offset = ACDconst - b x 3.336 uses 0.20 mm.
was analyzed and the value for the b-constant (the In our model, retinal thickness axial length cor-
slope coefficient) was almost exactly 1, so the simpler rections from 0 through 0.5 mm were tested and
form can be used with no sacrifice in accuracy. found to be very nearly equivalent in accuracy.
The patient's postoperative ACD is predicted, However, we noted that in long eyes, smaller
then, by adding the computed corneal height for the correction values gave best accuracy and in short
patient's eye to the offset of the IOL to be implanted eyes, larger values gave best accuracy. This led us to
(see formulas (4), (5), and (6) in the formula appen-
dix). Table 2 compares predicted postoperative ACD
values for short, medium, and long eyes from
different formulas.
Keratometry value of 43 D used for SRKIT and Holladay Fig. 4. (Retzlaff) Diagram of the eye showing retinal thick-
formulas ness, ultrasonic axial length, and optical axial length.
first English language publication was by Colen- Our goals were to (1) improve ease of use by
brander in 1973. 24 Other early theoretical models creating a theoretical formula under the SRK um-
were formulated by Thijssen,26 Van Der Heijde,27 brella that would use existing A-constant and optim-
and R.D. Binkhorst.l 9 All these formulas except ization methods and provide easy comparison of the
Fyodorov's used a constant value for estimated theoretical and regression approaches and (2), if
postoperative ACD. Early efforts to predict post- possible, improve on the accuracy of existing for-
operative ACD, mostly by using preoperative ACD mulas. This first point has been addressed in this
measurements, proved unsuccessful; thus, use of a paper; the second is addressed in a follow-up
fixed value remained standard practice until 1981 report.28
when Binkhorst recommended that estimated post-
REFERENCES
operative ACD be adjusted for different length
1. Retzlaff J. A new intraocular lens calculation formula. Am
eyes. 12 Shammas,22 Hoffer,14 Olsen,21 and Holla- Intra-Ocular Implant Soc J 1980; 6:148-152
d ay13 followed with their own methods of adjusting 2. Sanders DR, Kraff MC. Improvement of intraocular lens
estimated postoperative ACD. power calculation using empirical data. Am Intra-Ocular
We sought to enhance the accuracy of the theo- Implant Soc J 1980; 6:263-267
retical approach to implant power calculation by 3. Retzlaff J. Posterior chamber implant power calculation:
regression formulas. Am Intra-Ocular Implant Soc J 1980;
empirically and interactively optimizing the con- 6:268-270
stants in the formulas. The formula derived provides 4. Gills JP. Minimizing postoperative refractive error. Contact
a theoretical formula under the SRK umbrella that Intraocul Lens Med J 1980; 6:56-59
uses existing A-constants and optimization methods. 5. Sanders D, Retzlaff J, Kraff M, et al. Comparison of the
Software comparing the theoretical and regression accuracy of the Binkhorst, Colenbrander, and SRK™ im-
plant power prediction formulas. Am Intra-Ocular Implant
approaches has been developed for IBM personal Soc J 1981; 7:337-340
computers and compatibles and will be inbuilt in 6. Sanders DR, Retzlaff J, Kraff MC. Comparison of empiri-
most new A-scan units. cally derived and theoretical aphakic refraction formulas.
Table 5. Comparison of errors in prediction of implant power in 1,677 formula derivation cases.
*Standard error of estimate (in diopters) = '\hum (actual refraction - predicted refraction)2
N
FORMULA APPENDIX
VARIABLES
ACDeonst = constant used for anterior chamber depth in SRKIT formula for specific IOUsurgeon; can be computed from A-constant
ACD est = estimated postoperative anterior chamber depth for a given eye (mm)
A = constant used for SRKIT and SRK II
Aindiv = A-constant from postoperative values of an individual eye
C = short and long eye correction factor for SRK II
C w = corneal width computed from Land K (mm)
H = height of corneal dome (mm)
IOL = power of intended or implanted IOL (D)
IOLamet = power of IOL for given amount of ametropia, for a given REFTGT (D)
IOLemme = power of IOL for emmetropia (D)
K = averaged keratometry (D)
L = axial length measured ultrasonically (mm)
LOPT = "optical" axial length (mm) = L + RETHICK
LCOR = axial length with long eye correction; used in height formula
na = refractive index of aqueous and vitreous
ne = refractive index of the cornea
neml = ne minus 1, used in theoretical formula
offset = difference between corneal height of the average eye and the ACD-constant of a given IOL (see Figure 3)
r = averaged corneal radius of curvature (mm)
REF = actual postoperative refraction (D)
REFTGT = targeted or desired postoperative refraction (D)
REFX = expected postoperative refraction (D)
RETHICK = sensory retinal thickness (mm)
RF = refraction factor