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Tablets Notes
Tablets Notes
Tablets Notes
Introduction
Oral route is widely employed route for treatment
Unit dosage form: The dosage form which deliver one single
unit of dosage of the drug (Tablets and capsules)
Ease of swallowing
◦ Compressed tablets
Layered tablets
◦ Chewable tablets
Tablets used in oral cavity
◦ Dental cones
◦ Implantation tablets
◦ Vaginal tablets
◦ Effervescent tablets
◦ Diluents
◦ Binder or adhesive
◦ Disintegrant
◦ Lubricant
Disintegrants
Added to facilitate the breakdown of tablets when it
comes in contact of water in GIT.
◦ Product identification
Granulation methods
◦ Wet granulation
◦ Dry granulation
◦ Slugging/Compaction of tablet
components by means of a
press (slugs)
◦ Milling
◦ Screening
◦ Final compression
◦ Die filling,
Dies: for controlling the size and the shape of the tablet.
steps:
◦ Causes
◦ Air entrapment in the granules
◦ Rapid decompression
◦ Deep concave punches
◦ Use of too dry granulation tends to cap or laminate for
lack of cohesion
Causes:
Causes:
Remedy:
Causes:
Remedy:
◦ size,
◦ shape,
◦ color,
◦ taste
Size & shape of tablet dosage form
Content uniformity
Reasons: Non uniform distribution, Segregation and Tablet
weight variation
30 tablets taken
10 assayed individually
As per IP
Temperature maintained 37 ±
5ºC
Dissolution Test (U.S.P.)
◦ assay procedure