Professional Documents
Culture Documents
Annonaceous Acetogenins PDF
Annonaceous Acetogenins PDF
ANNONACEOUS ACETOGENINS
The Annonaceae (custard-apple family), considering its large size (130 genera and 2300 species), is chemically one of the
least known of the tropical plant families.
ketolactone
STRUCTURAL CLASSES
Three structural classes are currently evident when considering the number and arrangement of the tetrahydrofuran rings.
Annonacin as the first Annonaceous acetogenin containing a single tetrahydrofuran ring. Since this report
several other monotetrahydrofuran acetogenins have been described.
3. NONADJACENT BIS-TETRAHYDROFURAN ANNONACEOUS ACETOGENINS
All structures described so far are 4-hydroxy derivatives. From the spectral data published, almunequine appears to be in this
structural subclass, although the compound is not fully characterized.
4. NON-TETRAHYDROFURAN ANNONACEOUS ACETOGENINS
Cyclization
BIOGENESIS
The discoveries of muridienins, proposed precursors of the mono-THF acetogenins
1. Antibacterial
2. Antimalarial
3. In vivo antitumor
4. Parasiticidal
5. Pesticidal
6. thwarting resistance in multidrug resistant tumor and in pesticide resistant
insect.