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Telangyn
Telangyn
thread of redness
www.lipotec.com
In vitro efficacy
1. INHIBITION OF LL-37-INDUCED IL RELEASE telangyn™ peptide
The inhibition of the activity of LL-37 was measured by the release of the key pro-inflammatory lowers LL-37-mediated
cytokines IL-6 and IL-8 in human primary keratinocytes treated with LL-37 alone or with IL-6 and IL-8 release
telangyn™ peptide. Quantification was performed by ELISA. IL-6 levels decreased
by 24.2% and IL-8, by
22.8% with telangynTM
peptide at 0.5mg/ml.
2. ANTI-COLLAGENASE ASSAY Connective tissue
The anti-collagenase effect of telangyn™ peptide was evaluated by measuring the fluorescence degradation is reduced
of the fluorescein conjugate (gelatine). Fluorescence intensity is proportional to proteolytic by telangyn™ peptide
activity. telangynTM peptide
demonstrated a
statistically significant
-4
-6
-8
-10
-12
-14
-16
-17.7% -17.9%
-18
-19.2%
-20
7 days 28 days
-2
-4
-6
-8
-8.3%
-10
-12
-14
-14.3%
-16
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