Reconhecimento de patogénios

BCR/Anticorpos e TCR Moléculas de

região variável
Receptores da Imunidade Inata

1989 - Charles Janeway Jr. proposed the existence of

receptors expressed by innate immune cells responsible
for detecting conserved products of microbial origin.
Janeway CA Jr. Cold Spring Harb Symp Quant Biol. 1989. 54: 1-
13.
Receptores de PRRs BCR/Anticorpos e TCR Moléculas de
padrões
região variável
moleculares
microbianos
PRR

Receptores produzidos
por recombinação
Receptores
somática de
codificados
segmentos de genes
na linha
germinativa

Pattern Recognition Receptors (PRRs) are proteins

capable of recognizing molecules frequently found in
pathogens (the so-called Pathogen-Associated
Molecular Patterns—PAMPs)
PRRs BCR/Anticorpos
1994 e TCRthat
- Polly Matzinger proposed
Moléculas de
during tissue stress orregião damage,
variável
endogenous molecules are released and
activated and initiate or propagate the
inflammatory response (“Danger
Theory”).
Receptores
Matzinger P. Annu Rev Immunol. 1994.
produzidos por
12:991–1045.
recombinação
somática de
segmentos de
genes nas
These molecules are collectively known as
células B e T
DAMPs (Damage-Associated Molecular
Patterns).

PAMPs and DAMPs are recognized by

PRRs.
Our body is equipped to recognize “danger” that come from pathogens
and/or tissue damage.
The innate immune system recognizes microbial products that are often
essential for survival of the microbes
PRRs BCR/Anticorpos e TCR
Moléculas de
região variável

Receptores
produzidos por
recombinação
somática de
segmentos de
genes nas
células B e T
LOCALIZAÇÃO DOS PRRs

Robbins Basic Pathology, Ninth Edition. Vinay Kumar, Abul K. Abbas, and Jon C. Aster
 PRRs solúveis

Location Examples Ligands (PAMP/DAMP)

TLRs
 -
1-10

1984 - Toll é descoberto como o gene da Drosophila envolvido no estabelecimento do

eixo dorso-ventral.

Type I transmembrane
proteins characterized by
an extracellular domain
containing leucine-rich
repeats (LRRs) and a
cytoplasmic tail that
contains a conserved
region called the Toll/IL-1
receptor (TIR) domain
Localização dos TLRs
IRAK – IL-1R associated kinase
TRAF – Tumor necrosis factor receptor-associated factor
TAK - TGF-β-activated kinase TAB – TAK—1 bindind protein
Adapted from:
 PRRs

NOD - Nucleotide Oligomerization Domain–containing protein

RIG – Retinoic acid-Inducible Gene
 Citosol

NOD - Nucleotide Oligomerization Domain–containing protein

RIG – Retinoic acid-Inducible Gene
NOD - Nucleotide Oligomerization Domain–containing protein
IL-18

Pro-IL-18

IL-18
Robbins Basic Pathology, 9th Edition. Vinay Kumar, Abul K. Abbas, and Jon C. Aster
Ana Maria Santos (LORE e aluna do 3º ano do MIM)
Departamento de Relações Internacionais da Direcção da AEICBAS-UP