Santen SANTEN INCORPORATED MATERIAL SAFETY DATA SHEET SECTION 1. Chemical Product and Company Identification Product (Trade) Name: ALAMAST™ MSDS Preparation Date: June 2, 2000 Product Description: Ophthalmic solution MANUFACTURER: CONTACT INFORMATION: SANTEN INCORPORATED Telephone: (707) 254-1750 555 Gateway Drive Facsimile: (707) 254-1760 Napa, CA USA 94558 SECTION 2. Composition/Information on Ingredients Component) Synonym Formula MW] Approximate CAST Percent Weightweight “Gheorn Giycoroh, HOCH:CH(OH)GREOH | 92.1 <2 BETS Giycyl alcoho!; 12,3- Propanetri zs Pamirolast | 9-methyl-3(1H- | CiohiKNeO 286.3 Ot 700299-089 Potassium — | tetrazol-5-yi)-4H- pytidoft,2-0) pyrimidin-4-one potassium salt Tauraikonium | N.N-Dimethyl-Ne | CayHosNeCl 33997 (01005 139-077 chloride Dodecy Benzene methanaminium chloride; Laury! Dimethyt Benzyl ‘Ammonium chloride SECTION 3. Hazards Identification Emergency Overview: This product has been approved for the uses identified on the package insert. Use only as directed by this information. SECTION 4, First Aid Measures No specific medical treatment is necessary for skin or eye contact since this material is intended for topical ophthalmic use. Do not inhale mist or ingest. If inhaled or swallowed, rinse mouth out with water. Seek medical attention if adverse health symptoms develop. SECTION 5. Fire Fighting Measures Flash Point (C): Not applicable, Flammable Limits (LEL & UEL %): Not applicable. Auto Ignition Temperature: Not applicable, ALAMAST™ MSDS Page 1 of 3Santen SANTEN INCORPORATED MATERIAL SAFETY DATA SHEET SECTION 5. Fire Fighting Measures (continued) Extinguishing Media: Not applicable. Fire Fighting Procedures: Not applicable. Fire & Explosion Hazards: Not applicable. SECTION 6. Accidental Release Measures Spill containment, treatment, and clean-up procedures: No special spill containment or treatment is necessary. Absorb spill with inert material and place in a disposal container. SECTION 7. Handling and Storage Keep container closed. Store at temperatures and conditions indicated on the package insert SECTION 8. Exposure Controls/Personal Protection Ventilation and Engineering Controls: No special controls are required. Respiratory Protection: Respiratory protection is not necessary. Eye protection: Eye protection is not applicable. Skin protecti Skin protection is not necessary. SECTION 9. Physical and Chemical Properties Physical and chemical properties of product determined as a whole. Appearance and Odor: Clear, colorless to light yellow liquid, pH: Approximately 8 Specific Gravity (H,O Approximately 1 Boiling Point (C): Approximately 100° Melting Point (C): Approximately 0° Vapor Pressure: ND Evaporation Rate: ND Solubility in Water: Soluble in all proportions. N/D = Not determined. ALAMAST™ MSDS. Page 2 of 3Santen SANTEN INCORPORATED MATERIAL SAFETY DATA SHEET SECTION 10. Stability and Reactivity Stability: Stable. Hazardous Polymerization: Hazardous polymerization will not occur. Hazardous Decomposition: Hazardous decomposition will not occur. Conditions to avoi Contact with strong acids, bases, or oxidizers. SECTION 11. Toxicological Information For product specific information, including precautions, adverse reactions, and dosage, refer to package insert. SECTION 12. Ecological Information Data not yet available. SECTION 13. Disposal Considerations Dispose of material in accordance with local, state, and federal regulations. SECTION 14, Transport Information DOT Proper Shipping Name and Identification Number: Not regulated, Hazard class: Not applicable. SECTION 15. Regulatory Information Occupational Airborne Exposure Limits for Glycerin: OSHA Permissible Exposure Limit (PEL): 10 mg/m* total dust, 5 mg/m? respirable fraction for glycerin (mists). ACGIH Threshold Limit Value (TLV): 10 mg/m’ for glycerin mist containing no asbestos and <1% crystalline silica. SECTION 16. Other Information The information provided herein represents the most reasonable current information available when this assessment was performed. It is believed to be accurate and dependable. Santen Incorporated makes no representation as to the accuracy or sufficiency of this information. This product is intended for human ophthalmic use only. Use only as directed by package information, Santen Incorporated will assume no liability for the improper use of this product. ALAMAST™ MSDS Page 3 of 3