Rad enadupratibha.net UPSC DRUG INSPECTOR EXAMINATION PAPER 2011 Assume that for a diogoxin the therapeutic range is cited as Cavg 5.5 = 0.8 -2mg/ml, Ifthe patient is assumed to have an estimated digoxin t1/2 of 48 hours, how long would you waif'to take scrum dioxin concentration measurement and when during the dosing interval would you schedule it? 4) 28 days then 3 ~ 4 hours after the dose is administered ») 14 days then 6 ~ 8 hours after the dose is administered ©) T days then 10 ~ 14 hours after the dose is administered 4) 3 days then 1 — 2 hours after the dose is administered Which drug is used to prevent embolism in lungs and also during myocardial infraction 8) Human growth hormone b) Ateplase ©) Epogen (EPO) 4) Granulocyte ~ macrophage ebony stimulating factor (GM - CSF) Which enzyme is (sed! by the human immuno deficiency virus (HIV) to form deoxyribonucleic acid (DNA) in the host cell? 2) Restriction’endonuclease b)DNA ~ directed polymerase only {) Reverse transcriptase only 4) Both (b) and (@) For two drug products, generic and brand to be considered bio-equivalemt, the 90% confidence intervals about the ratio of the means of the Cmax and AUC values for getieric / brand product must be within 8) 80% ~ 120% of the brand product ') 80% — 100% of the brand product, ©) 80% — 85% of the brand product, <4) 80% — 90% of the brand product The renal clearance of inulin is used a8 a measurement of 2) Effective renal blood flow ») Active renal sectetion ©) Glomerular filtfation rate 4) Intrinsic enzyme activity ‘Which condition usually increase the rate of drug dis-solution from a tablet? 4) Increases in the particle size of the drug b) Use of the ionized or salt form of the drug ©) Decreases in the surface area of the drug Us of the free acid or free base form of the drug www.eenadupratibha.net2 10. 2 4 hi ww enadup ‘The mount of nitroglycerine that a transdermal patch delivers within a 24 hour period will not depend on 4) Occlusive backing on the path b) Diffusion rate of nitroglycerine from the patch ©) Surface area of the patch 4) Dissolution rate of nitroglycerine from the patch Avery fine powered chemical/drug is defined as one that 2) Completely passes trough a sieve #240 +) Completely passes through a sieve #120 ) Completely passes through a sieve #60 4) Passes through a sieve #60 and not more than 40% through a sieve #120 ‘Which equation is used to predict the stability offa drug product at room temperature from experiment at accelerated temperature? 4) The stokes equation >) The arthenius equation ©) The mickaelis ~ menten equation 4) The hixson ~ crbwell equation In 25 ml of a solution for a injection, there are 4 mg of the drug. If the dose to be administered to a patient is 200mg, what quantity of this solution should be used ? a125 ml ) 0.125 mi 912ml 12 ml ‘The rate of drug administration that gives the most rapid onset of the pharmacologic effeet is 4) Per oral administration >) Intradermal injection 6) Intravenous injection 4) Subcutaneous ijection Dose dumping ia a problem in the formulation of 28) Soft gelatin capsules >) Compressed tablets ©) Hard gelatin capsules 4) Modified release drug product ‘The extent of ionization of a weak elecifolyte drug is dependent on the 4) Particle size and surface aréalof the drug by Noyes ~ Whitney equatiOn for the drug ©) Polymorphic Forni of the drug 4) PHLof the fhedia and PKa of the drug ‘The\characteristc of an active transport process includes all ofthe following except 8) Active transport moves drug molecules against concentration gradient ’) Active transport follows kiek’s law of diffusion ©) Active transport require energy 4) Active transport of drug molecules may be saturated at high drug concentration16. WW. 18, vw. 21, hi ww enadup In order to determine the absolute bioavailability of «drug given as an oral extended release tablet, the bioavailability ofthe drug must be compared to bioavailability ofthe drug from 4) An immediate ~ release oral tablet containing the same amount ofthe active ingredient >) Aeference (brand) extended ~ release that is a pharmaceutical equivalent ©) A parenteral solution ofthe drug given by TV bolus or TV infusion 4) An oral solution of the drug in the same dose A single dose four ~ way cross over fasting, comparative bioavailability study was performed in 24 healthy, adult male subjects. Plasma drug concentration was obtained foe each subject and following result was obtained. Product Coax | Fan tO ], AUC) (Heim) | (Hghe/mt) TV injection 17a Oral emulsion 213 | 12 3143, Capsule " 24 2822 Reference tablet 165 19 ans ‘The relative bioavailability of the drug from the capsule compared to the reference tablet is 2) 82.3% b) 91.7% 2) 96.2% ) 103.9% How mafiy grams of aspirin should be used to prepare 1.250 kg of the given powder? Povider formula: ASA 6 parts Phenacetin 3 parts Calfeine 1 part a) 125 ») 750 ©) 186 4) 366 ‘Which technique is typically used to mill camphor? «) Levigation b)Pulvefization by intervention ©) Geometric dilution 6) Attrition Content uniformity test for tablets is used to ensure which quality ? ) Bioequivalency b) Potency, ©) Purity ) Toxicity ‘The route of drug administration that provides complete (100%) bioavailability is a) Intramuscular injection, ») Intravenous injection ©) Intradermal injection 4) Subcutaneous injection ‘The rate Of drug bioavailability is most rapid when the drug is formulated as a) Controlled release product, >) Hard gelatin capsules ©) Solution ) Compressed tablet2. 2. 28, 27. hi ww enadup ‘The sedimentation of particles in a suspension ean be minimized by which of the following ? 1) Adding sodium benzoate 2) Increasing the viscosity ofthe suspension 43) Reducing the particle size of the active ingredient 4) Adding a suspending agent Select the correct answer using the code given bellow a) Land 2 only b)2,3.and 4 oO) 13and 4 2 and 4 only Which one among the following statement is not correct? 4) Vaccines stimulate active immunity b) Vaccines are used for long term prophylaxis ©) Patient receives antibodies in active immunization, 4) Patient produces antibodies in active imfnuiization ‘Which one of the following is not bortect? 4) Vaccines are antigen containing, préparation >) Toxoids are bacterial foxins modified to destroy or reduce their toxicity ©) Antibody containig preparations are know as antisera 4) Vaccines aré used for passive immunization Class 100 etean room is defined as a room in which the particle count in the air is 4) Not more than 100 per cubic foot of 0.5jim and larger in size ’) Not more than 120 per cubic foot of O.5um_and larger in size ©) Not more than 100 per cubie foot of 0.5jum and larger in size 4) Not more than 99 per cubic foot of 0.3m in size Which of the following is not used as enteric coating material? 4) cellulose acetate phthalate ) Pectin ©) Actylase polymers 4) Polyvinyl acetate phthalate Which of the following can fit be-used for buffering of injection? 4) Phosphate buffers ») Citrate buffer ©) Borate buffers 4) Acetate buffers Which one of the following chemical / pharmacological classes of agents is incorrectly matched with its naturé'2 4) Adrenergic agonist : Basic ’b) Prostaglandin : Acidic ©) 4 ~ Quinolones : Basie d) Meglitinides : Acidic29, 3. 37. Aa enadup ny Which one of the following acids has the highest degree of ionization in an aqueous solution? a) Aspirin (pKa = 3.5) +b) indomethacin (pKa = 4.5) ¢) Ibuprofen (pKa = 5.2) d) Phenobarbital (pKa = 7.4) All ofthe following statement about first order degradation arc true, except 4) Ii rte is dependent on the concentration by Its half life isa changing parameter ©) A plot ofthe log of concentration versus time yields a straight line 4) ts toog is dependent ofthe concentration Vanishing eream is an ointment that may be classified as a) Awater soluble base b) An oleaginous base ©) An absoption base «) An emulsion base Rofecoxib 2) Has a similar effect to diclofenac, ») Provides protection against ischemiccardiovascular events 6) Is indicated for long term use in osteoarthritis. 4) Can be given.to patients with active peptic ulceration Schedule /R’ of drigs and cosmetics would apply to 4) Réquitement of factory premises and hygienic conditions for ayurvedic (including sidhba) drugs +b) Standards for mechanical contraceptives ©) Standards for medical devices 4) None of these ‘An alcoholic solution contains 57.77% w/v alcohol. The strength willbe labelled as ) Over proof b) Under proof ©) Proof spitit 4) Proof gallons Probenecid increases serum levels and prolongs activity of penicillin derivatives by ) Plasma protein binding, ) Blocking their glomerular filtration ©) Blocking their tubular secretion 4) Blocking their reabsorption In the preparation of célamine lotion, sodium citrate is used as 1) Suspending agent b) Solubilizers ©) Buffering agent ——_d) Bacteriostatic Water which is frée from volatile and non-volatile impurities, microorganism and pyrogens is called 2) Purified water IP 'b) Water for injection IP ) Sterile water for injection IP ) Potable water ‘Anew drug has completed phase -I clinical trail in USA, the pharmaceutical company wants to do the ‘multicentric, multinational trail including in india.The firm will apply in india to contact, 2) Phase — I trail >) Phase ~ I trail ©) Pre — clinical tail 4) Pharmacolimetric data trial41. 2, 4B. ww enadup Match the following. 1. Schedule V I. Particulars to be shown in the various records of manufacture of drugs 2. Schedule T I, List if drugs which can be marketed under generic names only 3, Schedule U IL. Life period of drugs 4, Schedule W IV. Standards of patent of proprictory medicines 5. Schedule P 'V. Requirements of factory premises and conditions for ‘ayurvedic and ‘Unani drugs Which is the correct match? a) LA, 2, $V, 4-V, 5-1 b) LV, 24, 34,40, 5-1 ©) LAY, 2-V, 34, 411, SI ) LIV, 2.V3-U1, 441, 5-111 0.9% wiv sodium chloride has a freezing point depression of a) -0.50°C b) -0.52°C ©) 056°C d) -058°C ‘Subcoating is given to the tablets'to a) Prevent dissolution in acidic medium ) Round the edges and build up the tablet size ©) Prevent moisturé penetration in to the tablet 4) Avoid Detetioration due to microbial attack ‘Whiclt one aifiong the following is observed in first order kinetic? 4) Clearance is constant 'b) Dose dependent elimination occurs «) Rate of elimination decreases with increases inplasma concentration 4) Rate of elimination does not depend on plasma concentration Which one of the following drug is not metabolized by liver? a) Phenytoin b) Erythromycin ©) Penicillin-G 4) Cefotaxime Which one among the following is not an oral third generation cephalosporin? 2) Cefiitoren b) Cefdinir ‘) Cefaclor «) Ceftibuten Which one among the following Statements Fegarding Placebo is correct? 4) Placebo does not product any effect >) Placebo is a dummy. itdieation ©) All patients respond to’placebo 4) Placebo is the itert material added to drug for making tables Pharthacovigilance is used to monitor 4) Unauthorized drug manufacturing ’) Drug toxicity ©) Pharmacokinetics 4) Cost of drugs and pharmaceuticals47. 49, Clonidine is a) Alpha one selective agonist ») Alpha two selective agonist ©) Alpha one selective antagonist 4) Alpha two selective antagonist Mala — N contains a) Ethiny Estradiol ) Norethisterone, ©) D-norgestrel «) Noreprinephrine Prolonged use of steroids may cause 8) Hypoglycemia ) Hypotension 6) Decrease in bone matrix protein 4) Barly healing of wound Anti-inflammatory action of glucocorticoids is due to blocking of 4) Prostaglandin synthase ) Thromboxane aynthase ©) 15 ~ lipoxygendse 4) Breakdown of phospholipids ‘Good Laboratory Practice (GLP) certification in India is '8) Mandatory for all pharmaceutical industries ) Compulsory for industries which involve in manufacturing of biologicals ©) Compulsory for industries which involve in manufacturing of nof-bidlogicals 4) Optional for pharmaceutical industries Good Laboratory Practice (GLP) certification is issued in India by 4) Controller, weights and measures, Government of India >) Bureau of indian standard (BIS), Government of India «) Department of scien and Techinology-Government of India 4) Drug controller General of India (OCGD, Government of India Which one of the following is Second generation H-Anti histamine? ) Cotrizine ) Cinnarizine ©) Pheneramine «promethazine Prostaglandins have effect on a variety of tissues in human body. The different Prostaglandins may have different effects. Which one of the following statement is not correct? 4) PGE? is bronchodilator where as PGF2 alpha is a broncho constrictor action +) PGE? has marked oxytoxie action while PGF2 alpha has tocolytic action ©) PGEland PGE2 inhibit platelet aggregation whereas TXA2 facilitate aggregation E2 AND PGI2, whereas TXA2 and PGF2 4) The human arteriolar smooth muscle is relaxed by PG alpha cause vasoconstriction58, 57, ol. 2, ww Ew enadup Which one of the following statements is true regarding NSAID's? 4) They cause release of histamine ) They cause relaxation of bronchial smooth muscle ©) They indirectly increase leukotriene production 4) They cause airway irritation Which of the following statement is not correct ? 4) Rate of killing of bacteria by antibiotic follows the first order kinetics, >) The bactericidal effects of penicillin depends upon its attainéd Cmax ©) The antibiotics having time dependent bactericidal effects af® given a large single dose rather then multiple daily doses 4) Aminoglycosides produce bactericidal effect ina concentration dependent manner Which of the following is not a correct combination of drug and its important adverse effect? 4) Rifampicin : Hepatotoxicity >) Isoniazide : Pepripheral neuropathy ©) Ethambutol : Increased rie, acid 4) Streptomycin : Otstoxicity ‘Chemotherapéuticagent, which docs not inhibit the microtubule formation is 2) Paclitaxel b) Colchicine ©) Vincristine 4) Vinblastine Following antibiotics have been correctly paired to their mechanism of action, except, 42) Vancomyci ~ Inhibits synthesis of phospholipids and peptidoglycan polymerization >) Tetracyline ~ Binds to 30s ribosome and inhibits protein synthesis, ©) Erythromycin ~ Binds to bacterial 70s ribosome and inhibits protein synthesis «) Ciprofloxacin — interferes with the action of bacterial topoisomerase IL ‘The pharmacokinetics ‘half-life of which one of the fOllowing resembles to its pharmacodynamic half-life? 8) Morphine >) Terfenadine 6) Isoprenaline «) Suxamethonium ‘The following properties of a drug encdtirage its accumulation in breast milk, exeept 48) High lipid solubility b) Unionized state ©) Low molecular weight ) Weak acid As per the schedule"y’ of the Drugs and Cosmetics Act, the animal toxicity study requirement for marketing, of,a"Grug depends upon tentative route and duration of administration in humans. In this Context which one of the following statements is incorrect? ‘a) Single dose human use-animal toxicity for 2 weeks in 2 species 'b) Oral use for 2 weeks in human- animal toxicity for 4 weeks in 2 species 6) Aerosol use by repeated use in human-animal toxicity 2 species for 24 weeks «d) Multiple daily ocular application for short duration-irrigation test in 1 species for 3 weeks67. 69, 70. ww Ew enadup In one of the clinical trails of vaccine, there were 6 deaths reported by the media, you have been deputed by authority to investigate the causality of incidence. Inspection of the following documents will be helpful except 8) Source data ») Standard operating procedures ©) Data safety monitoring records 4 Informed consent forms Which one among the following is an antimalarial drug having a metabolic with tisainé moiety? 8) Quinine ») Proguanil ©) Pyrimethamine 4) primaquine Which one among the following is an antitubercular drug with hydrazine moiety? 4) Ethionamide b) Isoniazide ©) Pyrarinaiside 4) Thiacetazone Codeine differ from morphine structurally in 4) Methaylation of phenolic hydroxyl group ») Methaylation of alcholic group ©) Methaylation of nitrogen group’ 4) Oxidation of phenolic hydroxyl group ‘Tropane system is fusion oF 2) pyrolidine ind piperidine >) pyrrolidine and pyrimidine ©) prroe and pyrazine 4) Thiophene and piperdine ‘The local anesthetics exert their action by blocking of the following types of ion channels 28) Ligand gated sodium channel ») Voltage gated sodium channel ©) Ligand gated calcium channel @ Voltage gated calciunt ehansiel Which one of the following statements with regard to the SAARC summit held/in bhutan in April, 2010 is not correct? 2) The summit has held in summit for the first time 'b) It was the silver jubilee summit of SAARC ©) The summit recommended to declare 20102020 a8 the ‘Decade of intra-regional connectivity in SAARC 4) The summit-central theme was Cross Border Terrorism’ Which one of the following statements with regard to the right to education Act, 2010is not correct? a) All children in 6-14 years age group must get free and compulsory eduction, ) No children shall besheld back, expelled or required to pass a board examination till class VIL ©) There must be 20% reservation for poor children even in private schools. 4) Gfam panchayats and municipal Councils are responsible to took into violations of Right to responsible to look into violations of Right to Education laws, ‘The next three items are based on the following passage ‘The detritus food chain (DFc) begins with dead organic matter. It is made up of decomposers which are heterotrophic organisms, mainly fungi and bacteria. They mect their energy and nutrients requirements by degrading dead organic matter or detritus. These are the saprotrophs which secrete digestive enzymes to break down the dead and waste matter into simple inorganic materials, which are subsequently absorved them. DFChi ww enadup may be connected with the grazing food chain at some levels-some of the organisms of DFC are prey to the grazing food chain animals. Some animals like cockroaches, crows etc.., are omnivores. These interconnections create a food web, Organisms occupy a place in their natural surroundings according to their feeding relationship with others. The source of their nutrition of food dictates its tropic level Autotrophs belong to the first trapic level and in turn feed the next tropic level of herbivores. Primary and secondary carnivorers constitute the third and fourth levels. Only about 10% energy gets transferred from the lower to the next higher tropi¢ level which eventually restricts the number of levels in a food chain 7, Which trophie level in the grazing food chain do Tion belong to? 4) Trophic level 1 by Trophic level 2 ©) Trophic level 3 4) Trophic level 4 72. ‘The number of trophic levels in grazing food chain is restieted because 4) The higher levels lke to restrict their numbet to improve availability ») Of loss availability of food from consiimption in the lower levels ©) Of an incremental number of organisms inthe next higher level 4) Of sequential transfer losS of entry ‘The trophic level of agiver species depends on it ) functionality” ) strength ©) number 4) size 74, The president of india has no power to grant pardon under Article 72 of the Constitution of India whete sentence 4) is given by court martial ’) of death has been awarded ©) is for an offense relating to a matter to which the executive power'to the Union extends 4) is for an offense relating to a matter to which the executive power to the state extends, 75. Who among the following won the Australia Opens Tennis Cup (Men's Singles) 2011? 1) Andy Murry b)Novak’Djokovie «) Rafael Nadal ) Floppy disk «) Hard disk ) Pendrive Witch among the following is/are units of RAM? a) Giga byte and Mega byte b) RPM. ) GBPS and MBPS ‘Select the correct answer the using the code given below. a) 1,2 and 3 by 1 and 2 ©) and 3 4) 1 only87. 89, m1, 92, ww enadup If you mix four parts of 40% with I part of 90%alcohol you will get 4) 45.7% alcohol ) 40% alcohol ©) 50% alcohol 4) 57% alcohol ‘The loading dose (DL) of a drug is usually based on the 4) Total body clearance of the drug ) Fraction of drug excreted unchanged in the urine ) Apparent volume of distribution (Vd) and desired drug concentration in plasma 4) Area under the plasma drug concentration versus time curye (AUC) ‘The activity of which one of the following drugs is depefidentGn a p-phenyl-N-alklypiperidine moiety? 2) Phenobarbital +) Chloropromazine ©) Imipramine <4) Merperidine Flurazepam has pKa of 8.2 what pereedtage of flurazepam willbe ionozed at a urine pH of 5.2? 8) 0.1% by 1% ©) 99% €) 99.9% Recrudescence of malas refers Yo the 8) Re ~ infection of patient by mosquito bite ) Re ~ infection by exocrythocytic hypozoites ©) Incémpleté clearance of sporozites from blood @ Taedmplete clearance of schizonts from blood Which one of the following drug should not be prepared in a horizontal laminar flow hood? 8) Ampicillin ) Dopamine ©) Cisplatin ©) Niteoglycerine Prostaglandin plays a major role in the biological activity of proton pumb inhibitor such as omeprazole and esomeprazole. The protonationtakes place on the 4) Aromatic methyl chain by Bemzimidzole ting ©) Methoxy side chain <®) The ring that has dimethyl groips ‘The carboxyl group aspirin afler esterification with N-acety-P-aminophenol gives 4) 3 ~ acclamidophéayl-O-Aeety salicylate >) 4 — acetamidaphenil-O-acety salicyate ©) 0 ~(hydtoxybenzoyl) salicycic acid 5.2) acetamidophenyl-0- cetyl salicylaye ‘A prescription order calls for $00 ml 2.0% aminosyn, but the pharmacy has 8.0% solution in stock. How much of the aminosyn 8.0% solution is required to prepare 500 ml of above solution? 2) 120 ml b) 147 ml ©) 125 ml 4) 250 ml96. ”. ww Ew enadup Which of the following is/are the symptoms of venous thrombosis? 1, Oedema, 2. Lower leg becoming bluish in colour. 3. Dry skin, Select the correct answer using the code given below. a) 1, Qand3 b) Land 2 only ©) 2and 3 only 4) Lonly Interferon beta 1. Can be administered orally. 2. May cause myalgia, 3. Is used in multiple sclerosis Which of the above statement is/are correct? a) 1, 2and 3 ) 1 and 2 only ©) 2and 3 only ) Lonly Which of the following is/are the side effects associated with testosterone? 1. Headache, 2, Hirustism. 3. Gynaecomastia, Select the corréct Answer using the code given bellow a) ands ) 1 and 2 only ©) 2and 3 only 4) Lonly Rosiglitazone 1. Should be used with caution in patients with cardiovascular disease 2. Should not be used with glicazide. 3. Is a biguanide, Which of the above statement is/are correct? 1, 2and3 by and2 only ©) 2and 3 only eT only Iron sats 1. Should always be taken on empiy stomach 2. Should be given by moult inkess there are good reasons for using another route 3. In the form of ferric'talisaf@ better absorbed than the ferrous salts Which of the aboye'Statement is/are correct? 2) 1, 2and3 b) 1 and 2 only ©) and 3 only 4) Tonly Doxveyeline 1, Is bacteriostatic, 2. Isa broad spectrum antibacterial drug 3. May be administered in renal impairment, Which of the above statement is/are correct? a) 1, 2and 3 by 1 and 2 only ©) 2and 3 only 4) 1 onlyRad enadupratibha.net 99, Testosterone may be used 1. To treat breast and endomettial cancer is females. 2. To treat hypogonadism in males 3, To suppress postpartum breast enlargement. Which of the above statement is/are correct ? a) 1, 2and 3 by 1 and 2 only ©) 2and 3 only 4) 1 only 100. Following adverse effects are rightly paired with a causative anti+ malaria drug except 4) Lichenoid skin eruptions : Chloroquine ) Steven ~ Johnson syndrome : Quinine «) Hallucinations : Mefloguine 4) Prolongation of QT interval : Halofantrife ANSWERS T-b; 2b; $e; dhe; S-e; 6-; Toa Be; 94; 10-a; L1-c; 12-d; 13d 14-b; 15-a 16-4; 17-b; 18-a5 19-b; 20-b; Doc; 22-b; 23-0; 24-d; 25ea; 26-b; 27-0; 28-a; 29-a; 30-b; 31-d; 32-c; 33-b; 3d-c; 35-d; 36-c; 37-b; 38d; 39-¢; 40-b; 41-b; 42-6; 43445/44-d; 45-b; 46-b; 47-b; 48-4; 49-¢; 50-2; 51-4 $2-d; 53-a; $4-c; $5-¢; 56-b; ST-c; S8-a; $9-a; 60a 64-b; 65-b; 66-a; 67-a; 68-b; 69-4; 70-c; Tec; T2-d; 73d; T4-b; 75-c; T6-b; T7-h T8b; 79-2; 80-c; 81-c; 82-c; 83-4; 84-c; 85-c; 86-d; 87-d; 88-c; 89-d; 90-b; 91-by92-c; 93-b; 94-c; 95b; 96-b; 9T-b; 98-4; 99-c; 100-«. COP etil ye mited