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Jurding Anak Polri
Jurding Anak Polri
Intervention • Zinc supplementation 3 x 15mg per day for 5 days or until defervescence
Comparison • Placebo
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INTODUCTION
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INTRODUCTION
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LATAR BELAKANG
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LATAR BELAKANG
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INTRODUCTION
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INTRODUCTION
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POPULATION
INCLUSION CRITERIA (≥2)
EXCLUSION CRITERIA
• < 1 YO
• Regularly assumed vitamins or minerals
• Chronic systemic diseases
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INTERVENTION
Bis-glycinate zinc (15 mg elemental zinc) Oral rehydration solution with identical
Prepared in powder form in single-dose flavor and packaging
sachets and dissolved in water
◆ Male, females
<10 yo
≥10 yo ≥10 tahun
• Morning 65 g/dL • Morning fasting 70 • Morning-fasting 74 g/dL
• Afternoon 57 g/dL g/dL • Morning non-fasting70
• Morning nonfasting 66 g/dL
g/dL • afternoon 61 g/dL
• afternoon 59 g/dL
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Fever criteria
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OUTCOME
◆ Primary outcome
◆ Defervescence phase assess
defervescence time of dengue inf.
◆ Secondary outcome
◆ Duration of hospitalization
◆ Presence of severe DVI
◆ Prevalence of zinc deficiency
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STATISTICAL ANALYSIS
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HASIL
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DISCUSSION
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Zinc dan lama rawat inap
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◆ This study 1st RCT
◆ Other studies systematic review in the presence
of zinc deficiency of malnutrition zinc supp the
average duration of diarrhea and the number of
children whose diarrhea persisted until 7 days
◆ Zinc supplementation clinically beneficial for
children > 6yo
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Zinc roles in some diseases
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Zinc and DVI severity
Clinical severity of dengue was similar in the low & high zinc groups, Widago
while the number of lymphocytes was significantly different
Toxic phase most of the patients had a moderate (40-60 g/dL) or Laoprasopwattana et al
marked (<40 g/dL) decrease in plasma zinc levels
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◆ Zinc essential micronutrient normal development
and function of cells mediating nonspecific immunity
◆ Zinc deficiency prevents outgrowth of T lymphocytes,
activation, Th1 cytokine production & B lymphocytes
help
◆ Studies in experimental human models CD8+ CD73+ T
lymphocytes, required for antigen recognition,
proliferation and cytolisis were decreased in zinc def
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Enteroaggregative E.coli induced
diarrhea
Zinc deficienct
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KETERBATASAN PENELITIAN
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◆ zinc supplementation at the admission may
contribute to shorten the hospital staying.
◆ Normal serum zinc levels at the baseline and zinc
supplementation during the acute phase of the
disease improve the clinical outcomes regarding
fever duration.
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CRITICAL
APPRAISAL
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Are the results of the trial valid ?
• Yes
• Yes.
• Yes. Number of participants in each group are the same, and the demographic
characteristics & antropometric data are almost equally the same
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Are the results of the trial valid ?
Were all patients who entered the trial accounted for ? And were
they analysed in the groups to which they were randomised?
• Yes. This study was a double-blinded study and the physicians that responsible for
the patients did not involved in the study
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Conclusion :
the results of the trial
valid
Will the result help me in caring for my patient ?
• Yes
39 • yes
Conclusion :
this result can be applied
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THANKYOU!
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