Name: Nicholas M.

Tagle NCM-RLE

Year & Section: BSN IV-A

Drug Study: Ranitidine Hydrochloride

Generic Name Indication Mechanism of Action Classification Side Effects/Adverse Nursing Responsibilities
Drug Reactions
Active duodenal and
gastric ulcer
Ranitidine H2 receptor  Adverse • Instruct patient on proper use of OTC
Adults: 150 mg P.O. preparation, as indicated.
Hydrochloride b.i.d. or 300 mg daily antagonist Reactions
• Remind patient to take once-daily
at bedtime. Or, 50 mg Competitively inhibits  CNS prescription drug at bedtime for best
action of histamine on the
Available Forms I.V. or I.M. every 6 to 8
H at receptor sites of
 headache results.
Granules hours. Maximum daily 
2

parietal cells, decreasing malaise • Instruct patient to take without regard

(effervescent): 150 I.V. dose, 400 mg. Or, to meals because absorption isn't affected
mg 150 mg by continuous gastric acid secretion.  vertigo
by food.
Infusion: 1 mg/ml in infusion at 6.25  EENT • Tell patient taking 150-mg EFFERdose
50-ml containers mg/hour over 24  blurred vision to dissolve drug in 6 to 8 ounces of water
Injection: 25 mg/ml
Syrup: 15 mg/ml*
hours.  Hepatic before taking.
Children ages 1 month • Tell parent to dissolve 25-mg
Tablets: 75 mg◊, 150 to 16 years: For  jaundice
EFFERdose tablet in at least 5 ml of water
mg◊, 300 mg duodenal and gastric  Other and give with a dosing cup, medicine
Tablets ulcers only, 2 to 4  anaphylaxis dropper, or oral syringe.
(effervescent): 25 mg, mg/kg P.O. b.i.d., up to
150 mg
 angioedema • Urge patient to avoid cigarette smoking
300 mg/day. because this may increase gastric acid
Maintenance therapy  burning and
secretion and worsen disease.
Administration for duodenal or gastric itching at • Advise patient to report abdominal pain
P.O. ulcer injection site and blood in stool or emesis.
• Give once-daily Adults: 150 mg P.O. at • Warn patients with phenylketonuria
dose at bedtime. bedtime. that EFFERdose granules and tablets contain
• Dissolve 150-mg Children ages 1 month aspartame.
EFFERdose tablet in 6 to 16 years: 2 to 4
to 8 ounces of water. mg/kg P.O. daily, up to
• Dissolve 25-mg 150 mg daily.
EFFERdose tablet in Pathologic
at least 5 ml of water hypersecretory
and give with a conditions, such as
dosing cup, medicine Zollinger-Ellison
dropper, or oral syndrome (ZES)
syringe. Adults: 150 mg P.O.
I.V. b.i.d.; doses up to 6 g
• To prepare I.V. or more frequent
injection, dilute 2 ml intervals may be
(50 mg) ranitidine needed in patients
with compatible I.V. with severe disease.
solution to a total Or, infuse continuously
volume of 20 ml, and at 1 mg/kg/hour. After
inject over at least 5 4 hours, if patient
minutes. Compatible remains symptomatic
solutions include or gastric acid output is
sterile water for greater than 10
injection, normal mEq/hour, increase
saline solution for dose in increments of
injection, D W, or
5 0.5 mg/kg/hour and
lactated Ringer recheck gastric acid
injection. output. Doses up to 2.5
• To give drug by mg/kg/hour and
intermittent I.V. infusion rates up to
infusion, dilute 50 mg 220 mg/hour have
(2 ml) in 100 ml been used.
compatible solution Gastroesophageal
and infuse at a rate reflux disease
of 5 to 7 ml/minute. Adults: 150 mg P.O.
The premixed b.i.d.
solution is 50 ml and Children ages 1 month
doesn't need further to 16 years: 5 to 10
dilution. Infuse over mg/kg P.O. daily given
15 to 20 minutes. as two divided doses.
• For continuous Erosive esophagitis
infusion to treat Adults: 150 mg P.O.
active duodenal or q.i.d. Maintenance
gastric ulcer, dilute dosage is 150 mg P.O.
150 mg in 250 ml of b.i.d.
D W. For
5 Children ages 1 month
hypersecretory to 16 years: 5 to 10
conditions such as mg/kg P.O. daily given
ZES, dilute with D W
5 as two divided doses.
or other compatible Heartburn
solution to no more Adults and children age
than 2.5 mg/ml. 12 and older: 75 mg of
• After dilution, Zantac 75 P.O. as
solution is stable for symptoms occur, up to
48 hours at room 150 mg daily, not to
temperature. exceed 2 weeks of
• Store I.V. continuous treatment.
injection at 39° to 86° Adjust-a-dose: For
F (4° to 30° C). Store patients with
premixed containers creatinine clearance
at 36° to 77° F (2° to below 50 ml/minute,
25° C). 150 mg P.O. every 24
• Incompatibilities: hours or 50 mg I.V.
Amphotericin B, every 18 to 24 hours.
atracurium, cefazolin,
cefoxitin,
ceftazidime,
cefuroxime,
chlorpromazine,
clindamycin
phosphate,
diazepam,
ethacrynate sodium,
hetastarch,
hydroxyzine, insulin,
methotrimeprazine,
midazolam,
norepinephrine,
pentobarbital
sodium,
phenobarbital,
phytonadione.