Topic: B1a15 Drug Development

Date: Class: Lesson Start: End:

Targets from
previous
lesson
Learning WALT:
objectives  How bacteria become resistant to drugs
(be as explicit  How pathogens can mutate to change the way they work
as possible –  How scientists test and trial drugs and why this is important
use the reverse
of the page if WILF:
necessary) All: Describe how mutation forms new strains of a virus that you are
not yet immune to.
Most: Explain why drug testing is so important, recall the thalidomide
disaster
Some: Evaluate the importance of drug testing against the amount of
time and cost to the companies involved
Pupil Speak We are learning about how new drugs are made because you need to be
able to trust the medicines you take
Key words Resistance, mutation, strains, antigens, antibodies, antibiotics,
thalidomide

Materials Worksheets B1a15a, B1a15c, Spot the difference photo handouts

Required
Safety N/A
Considerations
Relationship to
NC
Assessment opportunities (related to learning objectives)
During the Response to QUAD questions and completion of worksheets
lesson
After the
lesson
Time Pupil Activity Teacher activity
Starter:
“A drug is any substance that can
affect the internal chemistry of an
organism” (Refer back to beginning of
topic and legal/illegal drugs)

Show pictures of changing products –

what have they got in common?
 [The outside has changed but the
inside remains the same – it still
does the same job!]

Recall mechanisms that white cells

use to target pathogens

Focus on antibodies and give example

of mutated antigen. Why would a
virus benefit from such a mutation?
 [Most mutations are useless, even
killing the cells, whilst some are
beneficial]

Main part of lesson:

Talk about thalidomide and explain

why drug testing is so important.

Describe the four stages of testing and

copy “Clinical Trials” table into books

Complete W/S b1a15c

Plenary:
Relate mutation to bacterial resistance
and superbugs.

W/S b1a15a
Spot the difference...
Spot the difference...