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1.1 What Should We Know About Chlorhexidine - Chalermpomg - 0 PDF
1.1 What Should We Know About Chlorhexidine - Chalermpomg - 0 PDF
1.1 What Should We Know About Chlorhexidine - Chalermpomg - 0 PDF
Chlorhexidine
Chlorhexidine
Chlorhexidine digluconate
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Retrieved on 2013-05-28 from http://www.chlorhexidinefacts.com/mechanism-of-action.html
Solubility of Chlorhexidine and salts in Water
CHX & Salts %w/v at 20 C
CHX base 0.008
Di-acetate 1.90
Di-hydrobromide 0.07
Di-hydrochloride 0.06
Sulphate 0.01
Carbonate 0.02
Gluconate > 70
Digluconate > 70
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Applications of Chlorhexodine (di) Gluconate
Products CHG Concentration
Topical solution 2% or 3.15% with 70%
isopropanol
Scrub solution 2% or 4% aqueous
Washcloth 2% aqueous
Dental solution 0.12%
Gauze dressing 0.5% with paraffin
Catheter dressing 2% gel pad
Hand rub 1% alcohol based with emollients
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Pharmaceutical Incompatibility (1)
1.Physical
incompatibility
2.Chemical 3.Therapeutic
incompatibility incompatibility
• Visible incompatibility
• Hidden incompatibility 10 10
Pharmaceutical Incompatibility (2)
Some instance, there is no visible signs
of incompatibility, but the antimicrobial activity may
be significantly reduced
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1 2 3 4 5 6 7 8 9 10 11
2.0% CHG + NaOCl; 1: 6.0%, 2: 3.0%, 3: 1.5%, 4: 0.75%,
5: 0.38%, 6: 0.19%, 7: 0.094%, 8: 0.047%, & 9: 0.023%
10: 6.0% NaOCl & 11: 2.0% CHG (Control) 12
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The precipitate is most likely a salt form by the electrostatic
neutralization of the cationic chlorhexidine by the anionic EDTA.
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2.0% CHG + Water 2.0% CHG + NaOCl 2.0% CHG + EDTA
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Effect of Hand Sanitizing Gel/Rub on Antibacterial
Activity of Chlorhexidine (di) Gluconate Solution
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Purpose of the study (1)
To study the physical and chemical
incompatibilities of chlorhexidine (di) gluconate with
alcohol hand sanitizing gels.
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Methods
8 samples of alcohol hand Measurement of 2%w/v
sanitizing gel were collected Chlorhexidine gluconate
1 2 3 4 5 6 7 8 9 10
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Results (2): Chemical incompatibility
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40
5 mins
%Reduction of CHG
30 10 mins
15 mins
20 30 mins
60 mins
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0
Sample-1 Sample-2 Sample-3 Sample-4 Sample-5 Sample-6 Sample-7 Sample-8
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Effect of Lubricating Gel on Antibacterial Activity
of Chlorhexidine (di) Gluconate Solution
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Purpose of the study
To study the physical, chemical, and
therapeutic incompatibilities of chlorhexidine (di)
gluconate with lubricating gels.
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Methods
5 samples of lubricating gel Measurement of 2%w/v
were collected Chlorhexidine gluconate
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Results (2): Chemical incompatibility
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Results (3): Therapeutic incompatibility
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Effect of Different Solvents on Antibacterial
Activity of Chlorhexidine (di) Gluconate Solution
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Purpose of the study
To study the chemical, and therapeutic
incompatibilities of chlorhexidine (di) gluconate in
different solvents.
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Methods
3 samples of different Measurement of 4%w/v
solvents were collected Chlorhexidine gluconate
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Results (2): Therapeutic incompatibility
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Results (3): Therapeutic incompatibility
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Discussion (1)
Chemical incompatibility
Anionic – cationic interaction
(Charge neutralization)
Reduce/loss activity
Inorganic/organic anionic substances
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Incompatibility of
Discussion (2) CHX
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