Anton Gerald T.

Anes March 14,2019

8- Honesty Science PT

Hemophilia is a rare disorder in which your blood doesn't clot normally because it lacks sufficient
blood-clotting proteins (clotting factors). If you have hemophilia, you may bleed for a longer time after
an injury than you would if your blood clotted normally. Females can also have hemophilia, but this is
much rarer. In such cases both X chromosomes are affected or one is affected and the other is
missing or inactive. In these females, bleeding symptoms may be similar to males with hemophilia. A
female with one affected X chromosome is a “carrier” of hemophilia. A businesswoman, Samantha is
a carrier of an x linked recessive hemophilia and she’s engaged with Noel, a civil engineer and is
normal. In this case, the couple are bothered about their children someday regarding with her
condition.

XH Xh

XHXH XHXh
XH

XHY XhY
Y

Using the punnet square, we can identify here the possibility of their children having the
hemophilia. The couple has a possibility of having two boys and two girls children. As we can see on
the punnet square, there is a possiblity that their boys will have 50% chance of inheriting the disorder.
None of the girls will have it, but half of them are likely to be carriers. Despite of this condition that the
children could inherit the disorder, there are still ways on how to manage this. First, take care of
yourself by getting the right food, rest, and exercise.See your doctor for regular check-ups. Prevent
the pain of hemophilia by preventing bleeds.And lastly, The best way to reduce pain at the time of the
bleed is to treat immediately with factor. But the main treatment for hemophilia is called replacement
therapy. Concentrates of clotting factor VIII (for hemophilia A) or clotting factor IX (for hemophilia B)
are slowly dripped or injected into a vein. These infusions help replace the clotting factor that's
missing or low.

As a genetic counselor, my advice for this couple regarding their concerns is that for some people
with mild or moderate hemophilia A, treatment with desmopressin acetate (DDAVP) can be enough
to stop bleeding. First Aid with rest, ice, compression and elevation — known as RICE — helps slow
bleeding. RICE is also important while a bleed heals, which can take several days or even weeks.
Regarding on what food to avoid for those who have hemophilia, these are foods that they should
avoid: Calcium-rich foods include:
 ● low-fat or fat-free milk.
● low-fat cheese.
● Greek yogurt and 2 percent milkfat cottage cheese.
● calcium-fortified soy milk and orange juice.
● calcium-fortified cereals.
● beans.
● dark leafy greens like spinach and broccoli.
● almonds.

. At this time there is no cure for hemophilia. There is, however, great hope in a treatment known
as gene therapy. Several types of gene therapy are being tested. In general, gene therapy involves
taking normal genes (the ones that tell the body to make clotting factor) and putting them into the
body of a person with hemophilia. The new genes should cause the clotting factor level in the blood
to rise. People who had successful gene therapy would no longer need to take factor. They would be
cured of hemophilia. It is possible that the genes would only provide a partial cure. People with
severe hemophilia might be raised to the level of mild hemophilia. They would need to take factor less
often. In a small number of people with hemophilia who have had liver transplants, their hemophilia
has been cured. This is because clotting factor is made in the liver. The new livers they received
made normal amounts of factor for them. Transplants are too risky to use as a cure for hemophilia.
Liver transplants are done only to save someone's life when the liver has stopped working.