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    Complications: Virus Produces Antigen That Destroys Pancreas

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    Joy Manzano
    Diabetic ketoacidosis is caused by an absolute or relative deficiency of insulin leading to increased lipolysis and ketone production. This causes hyperglycemia, dehydration, and electrolyte imbalances. Symptoms include Kussmaul breathing, acetone breath, abdominal tenderness, and frequent urination. Treatment involves fluid resuscitation, insulin administration, and electrolyte replacement to stabilize blood sugar, pH, and potassium levels. Complications can include hypoglycemia, DVT, pulmonary or cerebral edema if not properly managed.

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    Complications: Virus Produces Antigen That Destroys Pancreas

    Uploaded by

    Joy Manzano
    8 views1 page
    Diabetic ketoacidosis is caused by an absolute or relative deficiency of insulin leading to increased lipolysis and ketone production. This causes hyperglycemia, dehydration, and electrolyte imbalances. Symptoms include Kussmaul breathing, acetone breath, abdominal tenderness, and frequent urination. Treatment involves fluid resuscitation, insulin administration, and electrolyte replacement to stabilize blood sugar, pH, and potassium levels. Complications can include hypoglycemia, DVT, pulmonary or cerebral edema if not properly managed.

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    Diabetic ketoacidosis is caused by an absolute or relative deficiency of insulin leading to increased lipolysis and ketone production. This causes hyperglycemia, dehydration, and electrolyte imbalances. Symptoms include Kussmaul breathing, acetone breath, abdominal tenderness, and frequent urination. Treatment involves fluid resuscitation, insulin administration, and electrolyte replacement to stabilize blood sugar, pH, and potassium levels. Complications can include hypoglycemia, DVT, pulmonary or cerebral edema if not properly managed.

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    8 views1 page

    Complications: Virus Produces Antigen That Destroys Pancreas

    Uploaded by

    Joy Manzano
    Diabetic ketoacidosis is caused by an absolute or relative deficiency of insulin leading to increased lipolysis and ketone production. This causes hyperglycemia, dehydration, and electrolyte imbalances. Symptoms include Kussmaul breathing, acetone breath, abdominal tenderness, and frequent urination. Treatment involves fluid resuscitation, insulin administration, and electrolyte replacement to stabilize blood sugar, pH, and potassium levels. Complications can include hypoglycemia, DVT, pulmonary or cerebral edema if not properly managed.

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    of 1

    Diabetic Ketoacidosis 3.

    CBG- target 350 mg/dl decrease gradually to 250


    1. absolute deficiency- no production of insulin 4. Potassium replacement
    2. relative- decrease production 5. pH- bicarbonate: below 7.1 target 7.2
    Causes: missed or inadequate dose Complications
    Increase requirement of insulin- infection 1. Hypoglycemia
    pneumonia and myocardial infaction 2. DVT
    * Virus produces antigen that destroys 3. Pulmonary edema
    pancreas 4. Cerebral edema
    Insulin deficiency causes: 5. increase blood sugar
    Glycogenolysis
    Lipolysis- releases FFA and glycogen HONK/ HHNC- Type 2 DM
    Ketones leading to ketosis Relative deficiency of insulin
    Decrease uptake of glucose- causing Signs and symptoms
    hyperglycemia, diuresis, dehydration and electrolyte 1. 3P’s
    imbalance. 2. weightloss
    Counter regulatory hormone of Insulin: 3. Obtunded- leading to coma
    1. glucagon 4. poor skin turgor
    2. epinephrine- inc. blood sugar 5. tachycardia
    3. cortisol- inc. blood sugar 6. decrease BP
    4. growth hormone Causes:
    Signs and symptoms Stopping of medication
    1. Kussmaul’s breathing Infection
    2. acetone breath MI, Stroke, Injury
    3. dehydration ABG, Xray
    4. frequent urination Treatment
    5. polydipsia, polyphagia, polyuria IVF 2L in 2 hours
    6. Ileus- decrease K Insulin
    7. concentrated urine Electrolytes
    8. tender abdomen Risk: Decrease potassium.
    3 Criteria
    1. Blood sugar greater than 300mg/dl
    2. Acidosis
    3. Ketonuria- ABG: pH 7.35; HCO3 <15meq
    Diagnostics
    1. RBS, FBS, HBA1c- <6.4, Fructosamine- blood sugar
    for the past 2 weeks.
    2. Serum electrolytes- K+, Na+, Cl-,
    3. BUN, Creatinine
    4. CBC- Anemia, infection
    5. Urinalysis- Sp. Gravity (concentrated)
    6. Chest Xray- Pneumonia, TB
    7. ECG- peaked T waves, MI
    8. ABG
    Goals:
    1. Fluid resuscitation (PNSS) 20mL/ kg X 1 hour X 2
    doses
    2. Insulin- Regular IV; 0..1 unit/kg- IV bolus
    0.1 unit/ kg/ hr. drip

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