HEMATHOLOGY 3 (MIDSEM)

PART B

1)Question 1 is based on this statement “Leukemia is a disease which can cause death if it is not
treated immediately”

1.a) Explain the 5 factors that causes leukemia

1.b) Elaborate classification of leukuemia

2.a) Explain chronic myeloid leukemina

2.b) Define acute leukemia

2.c) How acute leukemia is been classified

3) With the aid of a diagram, discuss the chromosome abnormality of chronic myeloid
philadephia leukemia positive.

4.a) Determine the function of each of the following cytochemistry staining below:

I. Myeloperoxidase
II. Sudan Black B
III. Periodic Acid Schiff

4.b) What are the aims of cytochemistry staining in leukemia?

5.a) Define systemic lupus erythematousus (SLE).

5.b) Briefly explain ‘flare’ in systemic lupus erythematousus.

5.c) Elaborate the antibody that involved in systemic erythematousus.

5.d) State 2 ways of treatment in order to cure SLE patient.

6.a) Define:

I. Myeloperoliferative disorders
II. Polycythaemia vera
III. Polycythaemia vera (Rubra)

6.b) List 2 diseases of hyperviscosity syndrome besides Polycythaemia vera.

6.c) What is the difference between Polycythaemia vera and pseudoplycythaemia?

PART C
 1) INFO:
NAME : MS. MANISHA
AGE: 46 YEARS OLD
CLINICAL FEATURES: fatique, pallor, might swelling, loose weight,
lymphadenopathy.
Ms.Manisha came to hospital with the above clinical features, the peripheral blood film
and bone marrow test is done. Diagnosis shows presence of abnormal cells I n total
number, size, and shape of the cell in the bone marrow. Based on above info, name the
type of leukemia involved and briefly explain your answer together with suitable lab test
and treatment to treat the patient.
2) Describe briefly on acute lymphoblastic leukemia, including the FAb classification
together with its description and diagram blood film.
3) *Picture; X-ray – shoulder and skull*
Figure 1 shows an important outcome of a lab diagnosis for a type of cancer that occurs
in the human body more than 97% of this disease occurs in elderly adult male over the
age of 40 as it involves the disturbance to the patient immunity system. Based on the
statement above, state the type of disease besides discuss the possible lab diagnosis and
treatment for the disease.

HEMATHOLOGY 3 (FINAL) PART B

1.a) Give definition of hemolytic anemia

1.b) State (3) mechanism involved in drug-induced hemolytic anemia

1.c) what is the relationship between hemolytic anemia and G6PD enzyme deficiency?

2.a) Define pancytopenia

2.b) List down the results obtained from bone marrow examination for aplastic anemia.

2.c) How cytotoxic drugs can lead to aplastic aniemia?

3.a) List the types of bone marrow preparation.

3.b) Briefly discuss the procedures of periodic Acid Schiff staining.

4.a) Describe the mechanism involved in haemostasis

4.b) Discuss on the mechanism of primary haemostasis

5.a) State the strengths and weakness of having automation machine in hematology lab.

5.b) In your opinion, what are the disadvantages of using manual method in hematology lab.

(Having a quality control and quantity assurance in the lab is a good practice in order to
monitoring the hematology test procedures that are performed in the lab.)

6.a) Based on the above statement, discuss the component of Quality Assurance program.

6.b) Will the aid of illustration, differentiate between accuracy and precision.

PART C

1) Discuss of primary and secondary causes of aplastic anemia and the clinical features
appeared.
2) Write a short notes on Hemophilia A.
3) Elaborate on the purpose of Quality Assurance (QA) together with its major activities of
QA.