vicissitudes

plural noun [vi-sis-i-toodz, -tyoodz]

successive, alternating, or changing phases or conditions,

as of life or fortune; ups and downs: They remained friends
through the vicissitudes of 40 years.
What is the origin of vicissitudes?
Vicissitudes, the plural of vicissitude, is about ten times more
common than the singular. Vicissitude comes via Middle French
from Latin vicissitūdō (inflectional stem vicissitūdin-) “change,
reversal, regular change or succession,
reciprocity.” Vicissitūdō derives from vicissim “in turn, for a
change, reciprocally,” a fossilized accusative noun used as an
adverb, from the noun vicis “a turn, change,
interchange.” Vicis (stem vic-) is the genitive singular of vix, a
noun form that does not exist in Latin. The element -cissim is a
combining form of the adverb cessim “giving way, yielding,” a
derivative of cēdere “to go, proceed.” Vicissitude entered
English in the second half of the 16th century.
How is vicissitudes used?
These are people who imagine their boutique blend of gold
and goodness can protect them from the vicissitudes of
life, even as their dynasty dissipates with each passing
generation.RON CHARLES, "IS THE END OF AN AMERICAN DYNASTY A REAL
TRAGEDY?" WASHINGTON POST, APRIL 29, 2019

The marble faces, which stand innumerable along the

walls, and have kept themselves so calm through
the vicissitudes of twenty centuries, had no sympathy for
his disappointment ....NATHANIEL HAWTHORNE, THE MARBLE FAUN,
1860