Sink condition is the ability of

the dissolution media to dissolve at least 3 times

the amount of drug that is in your dosage form.
Having sink conditions helps
your dissolution have more robustness as well as
being more biologically relevant. Why is 3 times the
magic number when it comes to sink condition?

What is s1 and s2 in dissolution?

Tablet Dissolution Test in Different Stages (S1, S2 and S3) ... This is the first stage of
the dissolution and known as S1 Stage. In S1 stage dissolved amount of each unit
should not be less than Q+5%.

How many types of dissolution are there?

Several dissolution apparatuses exist. In United
States Pharmacopeia (USP) General Chapter
<711> Dissolution, there are
four dissolution apparatuses standardized and
specified. They are: USP Dissolution Apparatus 1 –
Basket (37 °C ± 0.5°C )

What is non sink condition?

In the European Pharmacopeia, sink
conditions are defined as a volume of dissolution
medium that is at least three to ten times the
saturation volume. ... Otherwise, it is in non-sink
conditions. Mathematical simulation is a fast way to
predict and clarify the process and mechanism of
dissolution tests.
Why sink condition is important?
Sink condition is the ability of the dissolution media to dissolve at least 3 times the
amount of drug that is in your dosage form. Having sink conditions helps your
dissolution have more robustness as well as being more biologically relevant. Why is 3
times the magic number when it comes to sink condition?

What does Q stand for in dissolution?

Thread: Q Value
quantity 'Q' is the amount of dissolved active
ingredient specified in the monograph. Required to
be released in the stated time, expressed as a
percentage of labelled strength, then the batch of
the tablet or capsules is acceptable, if each
unit is not less than Q + 5 %.

What is dissolution rate?

The dissolution rate is a measure of the actual
release rate of the compound at the given particle
size etc. in an aqueous media. It often vary
considerably with solid form, e.g. particle size and
shape (read more about dissolution theory).

What affects dissolution?

Factors That Affect the Rate of Dissolving
A: The rate of dissolving is influenced by
several factors, including stirring, temperature of
solvent, and size of solute particles.

What increases the rate of dissolution?

If you are trying to dissolve a substance, you have
three primary avenues to increase the dissolution
rate: decreasing the particle size of the
solid, increasing the temperature
and/or increasing the mixing or stirring rate.

How do I calculate solubility?

Solubility indicates the maximum amount of a
substance that can be dissolved in a solvent at a
given temperature. Such a solution is called
saturated. Divide the mass of the compound by the
mass of the solvent and then multiply by 100 g
to calculate the solubility in g/100g .

What 3 factors affect how fast something dissolves?

Other factors that can affect this are the surface
area of the solid, temperature, and shaking/stirring.
If more surface area is available to interact with the
solvent, the solid will dissolve faster. Typically at
higher temperatures, solids will be more
readily dissolved than at a lower temperature.
What are the three types of solutions?
There are three types of solutions that can occur
in your body based on solute concentration: isotonic,
hypotonic, and hypertonic.

Why is dissolution important?

Dissolution testing has emerged as a
very important tool in the generic pharmaceutical
industry. It is very widely used in formulation
development, in monitoring the manufacturing
process and as a quality control test. It can also be
used to predict the in vivo performance of certain
products

Does pH affect solubility?

Solubility is Affected by pH
The pH of an aqueous solution
can affect the solubility of the solute. By changing
the pH of the solution, you can change the charge
state of the solute.
How does polarity affect solubility?
In addition, molecular polarity affects solubility in that polar molecules are best
solvated by polar solvent molecules and nonpolar molecules are best solvated by
nonpolar solvent molecules; i.e., "like dissolves like". ... If, however, the sum of the
bond polarities is not zero, the molecule is polar.

What is a supersaturated solution?

Supersaturation is a solution that contains more of
the dissolved material than could be dissolved by
the solvent under normal circumstances. It can also
refer to a vapor of a compound that has a higher
(partial) pressure than the vapor pressure of that
compound.

Does stirring affect solubility?

Stirring affects how quickly a solute dissolves in a
solvent, but has no effect on how much solute will
dissolve. The amount of solute that will dissolve
is affected by temperature - more will dissolve at
higher temperatures. This is called the solubility of
the solute .

How does increasing surface area speed up

dissolving?
When the total surface area of the solute
particles is increased, the solute dissolves more
rapidly. Breaking a solute into smaller
pieces increases its surface area and increases its
rate of solution. Stirring -- With liquid and solid
solutes, stirring brings fresh portions of the solvent
in contact with the solute.
What does Q stand for in dissolution?
Thread: Q Value
quantity 'Q' is the amount of dissolved active ingredient specified in the monograph.
Required to be released in the stated time, expressed as a percentage of labelled
strength, then the batch of the tablet or capsules is acceptable, if each unit is not less
than Q + 5 %.