t mtd standar

0.5 803 315

Profil Farmakokinetik
1 1484 1748
1.5 1789 1889 2500
2 1884 2049
2000
2.5 2085 1640
3 1890 1659 f(x) = - 68.0888995101x + 1811.9000677102
f(x) mtd
1500 R² ==0.6039407157
- 62.2258334329x + 1707.3563548015

MTD-Standar
4 1676 1614 R² = 0.4504071751 Linear (mtd)
6 1677 1592 standar
1000
Linear (stan
8 1482 1510
10 1072 1013 500
14 538 519
24 154 180 0
0 5 10 15 20 25 30

t standar waktu (t)

0.5 315
1 1748
1.5 1889 t mtd t standar
2 2049 0.5 6.688355 0.5 5.752573
2.5 1640 1 7.302496 1 7.466228
3 1659 1.5 7.489412 1.5 7.543803
4 1614 2 7.541152 2 7.625107
6 1592 2.5 7.642524 2.5 7.402452

1510
8 3 7.544332 3 7.41397
10 1013 4 7.424165 4 7.386471
14 519 6 7.424762 6 7.372746
24 180 8 7.301148 8 7.319865
10 6.977281 10 6.920672
14 6.287859 14 6.251904
24 5.036953 24 5.192957

C (ng/ml) LnC(ng/ml)
t
MTD standar MTD Standar Profil Farmakokineti
0.5 803 315 6.688355 5.752573
1 1484 1748 7.302496 7.466228 9
1.5 1789 1889 7.489412 7.543803 8
2 1884 2049 7.541152 7.625107 7 f(x)
f(x) == -- 0.0949480932x
0.0801026098x ++ 7.6603307004
7.4813830044
Ln MTD-Stamdar (ug/ml)

R²
R² == 0.7598227515
0.4791180386
2.5 2085 1640 7.642524 7.402452 6
3 1890 1659 7.544332 7.41397
5
4 1676 1614 7.424165 7.386471
4
6 1677 1592 7.424762 7.372746
3
8 1482 1510 7.301148 7.319865
10 1072 1013 6.977281 6.920672 2
14 538 519 6.287859 6.251904 1
0
0 5 10 15 20 25
Waktu(t)
 Ln MTD-S
3
2
1
24 154 180 5.036953 5.192957 0
0 5 10 15 20 25
Waktu(t)
inetik Kurva Absorbansi
2500

2000
f(x) = 301x + 1443.8333333333
f(x)==0.9986735939
R² 400x + 1119
677102 mtd R² = 0.9158557527 Standar
548015 1500
MTD- Standar
Linear (mtd) Linear (Standar)
standar MTD
1000
Linear (standar) Linear (MTD)

500

0
25 30 0.8 1 1.2 1.4 1.6 1.8 2 2.2
waktu ( t )

YANG MERAH SALAH

ofil Farmakokinetik

932x
098x ++ 7.6603307004
7.4813830044
5
6
mtd
Linear (mtd)
standar
Linear (standar)

15 20 25 30
Waktu(t)
 Linear (standar)

15 20 25 30
Waktu(t)
 Kurva Eliminasi
1200
1000
800 f(x)
f(x) == -- 60.3461538462x
54.5769230769x ++ 1553.5384615385
Standar
1443.8974358974
MTD - Standar

R²
R² == 0.8909004252
0.88268925 Linear (Standar)
ndar 600
MTD
ear (Standar) 400
Linear (MTD)
D 200
ear (MTD) 0
8 10 12 14 16 18 20 22 24 26
waktu ( t )

Eliminasi

8.2766643246
8.0424874617

Column F
Linear (Column F)
Column I
Linear (Column I)

20 22 24 26
 Linear (Column I)

20 22 24 26
 C (ng/ml) LnC(ng/ml) LnC' C'
t
MTD standar MTD Standar MTD Standar MTD Standar
0.5 803 315 6.6883547 5.7525726388 8.2087 7.9825 3672.765 2929.245
1 1484 1748 7.3024964 7.4662275562 8.1407 7.9225 3431.319 2758.659
1.5 1789 1889 7.4894121 7.5438028675 8.0727 7.8625 3205.746 2598.007
2 1884 2049 7.5411525 7.6251071482 8.0047 7.8025 2995.001 2446.711
2.5 2085 1640 7.6425241 7.4024515208 7.9367 7.7425 2798.111 2304.226
3 1890 1659 7.5443321 7.4139702902 7.8687 7.6825 2614.165 2170.038
4 1676 1614 7.4241653 7.3864708488 7.7327 7.5625 2281.755 1924.651
6 1677 1592 7.4247618 7.3727463664 7.4607 7.3225 1738.364 1513.984
8 1482 1510 7.3011478 7.3198649298 7.1887 7.0825 1324.38 1190.942
10 1072 1013 6.9772813 6.9206715042 6.9167 6.8425 1008.985 936.8283
14 538 519 6.2878586 6.2519038832 6.3727 6.3625 585.6369 579.6938
24 154 180 5.0369526 5.1929568509 5.0127 5.1625 150.31 174.6004

C (ng/ml) LnC(ng/ml) Ln(C'-C) t

t
MTD standar MTD Standar MTD Standar 0.5
0.5 803 315 6.6883547 5.7525726388 7.961985 7.868731 1
1 1484 1748 7.3024964 7.4662275562 7.574209 6.918358 1.5
1.5 1789 1889 7.4894121 7.5438028675 7.256118 6.563866 2
2 1884 2049 7.5411525 7.6251071482 7.013017 5.985726 2.5
2.5 2085 1640 7.6425241 7.4024515208 6.569638 6.498622 3
3 1890 1659 7.5443321 7.4139702902 6.585019 6.236444 4
4 1676 1614 7.4241653 7.3864708488 6.406475 5.738671 6
6 1677 1592 7.4247618 7.3727463664 4.116831 4.356911 8
8 1482 1510 7.3011478 7.3198649298 5.060185 5.765372 10
10 1072 1013 6.9772813 6.9206715042 4.143375 4.33299 14
14 538 519 6.2878586 6.2519038832 3.863608 4.105841 24
24 154 180 5.0369526 5.1929568509 1.305619 1.686323

Kurva Absorbansi
9
8
7 f(x)
f(x) == -- 0.7058676055x
1.3048648308x ++ 8.3033049016
8.4218496226
R² = 0.9967617677
R² = 0.935004992
6 MTD
5 Linear (MTD)
Ln C'-C

4 standar
3 Linear (standar)
2
1
0
0.4 0.6 0.8 1 1.2 1.4 1.6
Waktu(t)
 C'-C Ln(C'-C)
MTD Standar MTD Standar
2869.764767237 2614.24503 7.9619853428 7.8687306275
1947.318950777 1010.65908 7.5742088085 6.9183579513
1416.745667947 709.0072816 7.2561177373 6.5638657967 YANG
DIMASUKIN KE
1111.001465904 397.7111158 7.0130171091 5.9857259021
713.1114879003 664.2257528 6.5696377727 6.4986220808
724.1649638076
605.7546287696
511.0380914
310.6511317
6.585019217
6.4064750011
6.2364441302
5.7386705194
WORD INI AJA
61.3644866896 78.01579699 4.1168312751 4.3569113317 <<--
157.6196084883 319.0578447 5.060184589 5.7653724177
63.015155423 76.17171972 4.1433752597 4.3329902615
47.6369158374 60.69378081 3.8636080035 4.105841235
3.6899741685 5.399588538 1.3056194576 1.686322754

MTD t standar
7.9619853428 0.5 7.8687306275
7.5742088085 1 6.9183579513
7.2561177373 1.5 6.5638657967
7.0130171091 2 5.9857259021
6.5696377727 2.5 6.4986220808
6.585019217 3 6.2364441302
6.4064750011 4 5.7386705194
4.1168312751 6 4.3569113317
5.060184589 8 5.7653724177
4.1433752597 10 4.3329902615
3.8636080035 14 4.105841235
1.3056194576 24 1.686322754

FK ELIMINASI
MTD y = -0,0949x + 7,6y = -0,136x + 8,2767
STD y = -0,0801x + 7,4y = -0,12x + 8,0425

AUC (A/α)+(B/β)
 A α B β AUC
3931.2 0.136 2122.394 0.0949 51270.41
3110.379 0.12 1774.724 0.0801 48076.18
 C (ng/ml) Ckumulatif ∆t AUC-linier
t
MTD standar MTD standar MTD Standar MTD
0.5 803 315 803 315 0.5 0.5 200.75
1 1484 1748 2287 2063 0.5 0.5 571.75
1.5 1789 1889 4076 3952 0.5 0.5 1019
2 1884 2049 5960 6001 0.5 0.5 1490
2.5 2085 1640 8045 7326 0.5 0.5 2011.25

3 1890 1659 9935 9300 0.5 0.5 2483.75

4 1676 1614 11611 10914 1 1 5805.5

6 1677 1592 13288 56005 2 2 13288
8 1482 1510 14770 70775 2 2 14770
10 1072 1013 15842 86617 2 2 15842
14 538 519 16380 102997 4 4 32760
24 154 180 16534 119531 10 10 82670
AUC-linier AUC Total AUCt
Standar MTD Standar MTD Standar Parameter Farmako
78.75 200.75 78.75 200.75 78.75 t1/2
515.75 772.5 594.5 571.75 515.75 MTD 5.095588
988 1791.5 1582.5 818.25 909.25 Standar 5.775
1500.25 3281.5 3082.75 918.25 984.5
1831.5 5292.75 4914.25 992.25 922.25
2325 7776.5 7239.25 993.75 824.75
5457 13582 12696.25 1783 1636.5
56005 26870 68701.25 3353 3206
70775 41640 139476.3 3159 3102
86617 57482 226093.3 2554 2523
205994 90242 432087.3 3220 3064
597655 172912 1029742 3460 3495
Total : 22024 21261.75
Parameter Farmakokinetik Urin FK
AUC 0-24 AUC 24-~ AUC 0-~ t maks C maks MTD y = -0,0949x + 7,6603
22024 1132.353 23156.35 2.889663 STD y = -0,0801x + 7,4814
21261.75 1500 22761.75 2.014001
1.3284003827

B 3931.2
A 4037
ELIMINASI absorbsi
y = -0,136x + 8,2767 y = -0,7059x + 8,3033
y = -0,12x + 8,0425 y = -1,3049x + 8,4218

3.519873828

3110.4
4545