AAOA

Minor Blood Group System

Characteristics: Reminder:
1. Minority of the population have it 1. Know the Antigen present
worldwide. 2. Know the Antibody present
2. It was named after the first antibody marker 3. Know the symbol → first 2 letters
producer (patient’s surname). 4. Know the ISBT #
3. It is known to be IgG. 5. Know if it will cause HDN/HTR
Because there are some cases that:
  HDN X HTR
 X HDN  HTR
 Does not cause both HDN & HTR

Blood
ISBT Antibody Other
Group Symbol
#
Antigen present HDN HTR
Present Information
System
 Have 22
antigens
 Wra
 Wrb Example
 Dia →common in  Wu
Mongolian race  Served as
→discovered in 1955 in a
useful in
Diego Di 010
Venezuelan baby  Anti-Dia
 Anti-Dib  anthropologic
studies of
 Dib → most common;
have high Mongolian
incidence/frequency ancestry
 Anti-thelical
antigens =
inversely
proportional
 YTa → Immunogenic;
Reactive
 YTb → Poor  Location:
immunogenic; Weakly  Anti-YTa
Acetylcholine
reactive – more sterase
Cartwright YT/Yt 011  YTa-b+ = YTb – rare or
low incidence
common X X (ACHE) – for
 Anti-YTb neurotransmissi
 YTa+b- = YTa High
on
 YTa+b+ = YTab Incidence
 YTa-b- = YTab- - not yet
discovered
 AAOA
Blood
ISBT Antibody Other
Group Symbol
#
Antigen present HDN HTR
Present Information
System
 Gene that
encodes for
XG allele is
located on the
short arm of
X
chromosome
 The first
 Anti-Xga
patient in U.S
XG XG 012
 Xga → more common
 CD99
 Alloanti-
CD99 → X  was treated in
Grand
rare
Rapids
 XG can affect
both gender
but it is
common in
female
 89% female
 66% male
Original Renamed  Anti-Sc1
Sc1 – high  Anti-Sc2
Sm
prevalence  Anti-Sc3

Scianna Sc 013 Bua

Sc2 – low
prevalence
– most
clinically X 
significant (Mild)
Sc3 -reactive in
Sc4 IAT
 Anti-Sc4
Reacts
with
Anti- IAT
Doa Poor Doa with
Dob immunogen Anti- PEG or
Dob enzyme
enhanc

Dombrock Do 014 Gregory

High
immunogenic
ement
Red
X

cell (Delay
(Gya) (most stimul ed)
reactive) anti-Gya ated
Holly Most anti-Hy antibo
(Hy) common; anti-Joa dies;
Highly IAT
Joseph
prevalent reactiv
(Joa) e
 AAOA

Blood
ISBT Antibody Other
Group Symbol
#
Antigen present HDN HTR
Present Information
System
 Discovered in
Calton
 Found in
Low
Cob Channel-
prevalence
forming
integral
 Anti-Coa
protein
Colton Co 015
 Anti-Cob
 Anti-Co3  (CHIP) –
responsible
 Anti-Co4
for water
Coa permeability;
High
Co3 forms the
prevalence
Co4 primary
erythrocyte
water channel
Low
LWb  Anti-LWa  Companion of
Landsteiner frequency
-Wiener
LW 016 LW a
High  Anti-LWb
 Anti-LWab
X X Rh (-) blood
grp
LWab frequency
 Anti-Ch/Rg
→ high
titer, low  Associated
avidity and with HLA
shares  Found on
common chromosome
rare rare
Chido-
CH/RG 017 Ch/Rg serologic 6
Rogers properties.  Neutralized
*High titer = by pooled
high amount plasma
of serum,  C4A & C4B
decrease
reaction
 From Mrs.
Gerbich
Ge2 Anti-Ge2
 Inherited on
Ge3 Anti-Ge3
Gerbich Ge 020 GeAT
GePL
Anti-GeAT
Anti-GePL
 chromosome
2
 Found on
GeTI Anti-GeTI
glycophorin
C&D
 AAOA

Blood
ISBT Antibody Other
Group Symbol
#
Antigen present HDN HTR
Present Information
System
 Carried by
DAF (Decay
Cra Low Accelerating
Crb frequency Factor) –
involved with
 Anti-Cra
the regulation
Cromer Cr 021
 Anti-Crb
 Anti-Tca X  of
complement
 Anti-Tcb
Tca activation by
High  Anti-Tcc
Tcb accelerating
frequency the decay of
Tcc
the C3 and C3
convertase
 Located on
chromosome
Knops Kn 022
Kna
Knb
High
incidence
 Anti-Kna
 Anti-Knb X  1
 Resides in
complement
receptor 1
 Carried by
CD44 –
known for
Indian In 023
Ina
Inb
High
incidence
 Anti-Ina
 Anti-Inb X  immune
adhesion
property.
 Common in
Indian race.