Drugs and the Brain

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About this Course

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The neuroscience of drugs for therapy, for prevention,

and for recreation.  Drug addiction and drug abuse.
You’ll learn the prospects for new generations of
medications in neurology, psychiatry, aging, and
treatment of substance abuse.
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English
Subtitles: English, Greek

When I need courses on

topics that my university
doesn't o er, Coursera is
one of the best places to
go.
— Larry W.

○ ● ○

Syllabus - What you will

learn from this course
 WEEK

1
3 hours to complete

Week 1.
Organization and
Overview
The description goes here

11 videos (Total 123 min), 1 quiz SEE ALL

11 videos

1. Organization and Overview, weeks 1 - 3 11m

WEEK

2. Organization and Overview, weeks 4- 7 9m

3. What is a Drug? 13m 2

4. Drug Entry Into the Nervous System 12m
2 hours to complete

5. Introduction to Drug Receptors 11m

Week 2. Dose-
6. More about receptors as proteins 13m
response Relations
7. Introduction to Mammalian Brains 9m
The description goes here
8. Techniques for Studying the Brain 10m

10 videos
9. Botulinum toxin (Total
9m 92 min), 1 quiz SEE ALL

10. Origin of the Resting Potential 10m

10 videos
11. Electrical Aspects of Ion Channels 8m

1 Qualitative Approaches 9m
WEEK
1 practice exercise
2 Quantitative Approaches, Agonist Only 10m

Quiz on miniLectures 1-11 36m

3 Agonists plus Antagonists 7m 3
1 The Synapse as a Drug-Sensitive Biophysical
3 hours to complete
Machine 8m

Week 3. G protein
2 Nicotinic Acetylcholine Receptors: Activation 10m

pathways
3 Nicotinic Acetylcholine Receptors: Desensitization
5m
The description goes here
4 Inhibitory Ligand-gated channels 9m

10 videosreceptor
5 Glutamate-gated (Total 118 min), 1 quiz
channels 11m SEE ALL
1 Pore Blockers at ligand-gated channels 6m
10 videos
2 Voltage-gated channel blockers 11m
1 Principles and Receptors 13m
WEEK

2 Inhibitory
1 practice
G Proteins
exercise
and their E ectors 7m

Quiz
3 Theon
Stimulatory
Week 2 miniLectures
G Protein (Gs)
32mPathway 11m 4
4 The Ca-mobilizing G protein (Gq) pathway; Modifying
3 hours to complete
G protein Pathways 11m

Week 4. Nicotine
5 “Outside-in” Mechanisms for Long-term Actions on G
Protein Pathways 12m
Addiction
1 Drugs Bind to Neurotransmitter Transporters 15m
The description goes here
2 Neurotransmitter Transporters as Molecules 11m

12 videos
1 Overview 10m (Total 145 min), 1 quiz SEE ALL

2 Targets 8m

12 videos
3 System level e ects 14m

1 Components of addiction. Animal models 15m Show More

1 practice exercise
2 Circuit and cellular level. "Outside-In" Mechanisms
11mon Week 3 miniLectures 38m
Quiz

3 Circuit and Cellular Level: Upregulation via “Inside-

Out” Mechanisms 16m

Instructor
4 Recent Genetic Data 13m

5 Drugs for smoking cessation; Harm Reduction 14m

1 Components of Opiate Addiction 10m

2 Circuits and Animal Models 10m

3 “Outside-In” Mechanisms 12m

Henry A. Lester, PhD

4 Drugs for Harm Reduction in Opiate Addiction 5m
Bren Professor
Division of Biology and Biological Engineering
1 Clinical Description & Genetics 10m

2 Pathophysiology 16m

3 Biomarkers & Therapeutic Approaches 8m

1 practice exercise
About Caltech
Quiz on Week 4 miniLectures 30m
Caltech is a world-renowned science and
engineering research and education institution,
where extraordinary faculty and students seek
answers to complex questions, discover new
knowledge, lead innovation, and transform our
future. Caltech's mission is to expand human
knowledge and bene t society through research

integrated with education. We investigate... MORE

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