Professional Documents
Culture Documents
Dose Presentation
Dose Presentation
Clinical Population
Diagnostic Dose
Confidence Risk
GE Medical Systems
Tom Toth
1
Introduction
n What is X-ray dose
n How is dose measured in CT
n Regulations regarding dose
n Reducing Patient Dose
2
What is Dose ?
Absorbed energy from exposure to ionizing radiation
X-ray Photons
L
K
Genetically
Genetically damages
damages or
or kills
kills living
living cells
cells
3
Dose Measurement Units
• Exposure
• air kerma (mGy) (Roentgen is old unit, 87.6 mGy = 1 R)
– kerma - kinetic energy released in material
• 1 mGy is approximately 3 ×10-6 Coulombs /kg
4
Acute
Acutebiological
biologicaleffects
effectsof
ofIonizing
IonizingRadiation
Radiation
Exposure
ExposureLevels
LevelsatatWhich
WhichHealth
HealthEffects
EffectsAppear
AppearininHealthy
HealthyAdults
Adults
Acute
AcuteWhole-body
Whole-bodyRadiation
RadiationSyndromes
Syndromes
Biological
Biologicaleffects
effectsat
athigh
highdoses
dosesare
arewell
wellknown
known 5
The
TheLinear
LinearNo
NoThreshold
ThresholdRadiogenic
RadiogenicCancer
CancerRisk
RiskModel
Model
Acute
Acute
measurable
measurable
Effects
Effects
Stochastic
Stochastic
Effects
Effects
Radiogenic
Cancer and
Genetic
Risks
Typical
TypicalCT
CTExam
Exam 1-20 500 1000 1500
Effective Dose 2000
Effective Dose
Dose (mGy)
Population
PopulationRisks
Risksat
atDiagnostic
DiagnosticDose
DoseLevels
Levelsare
areStatistically
StatisticallyEstimated
Estimated
Based studies of Japanese A-Bomb survivors and nucular accidents
Based studies of Japanese A-Bomb survivors and nucular accidents
6
Sources of Radiation Exposure
Received by US population
From NCRP Report No. 93
1%
3%
Radon
4%
11% Other Natural Sources
Medical X rays
Nuclear Medicine
55%
26% Consumer Products
Other
CT
CTaccounts
accountsfor
for33--4%
4%ofofmedical
medicalexaminations
examinations
and
and10
10--40%
40%of
ofthe
thetotal
totaldose
dosecontribution
contribution
Source FDA TEPRSSC meeting May, 2000
7
How does CT dose compare to
other sources?
Radiation
Radiationper
peryear
yearfrom
from cigarette
cigarettesmoking
smokingisisabout
aboutequivalent
equivalentto
toaaCT
CTscan
scan
8
Stochastic Biological Risk vs Dose
• Organ dose - Dose to specific organs
• Effective Dose - The organ dose expressed as the whole body dose that
lung _ risk
effective _ dose = lung _ dose ×
produces the same biological risk: example: whole _ body _ risk
160
140
Risk
Risk x10 -4
120
Cancer Mortality
100
Per 1000 mGy
80
Cancer Mortality
60
40
20
0
Esophagus
Remainder
Leukemia
Stomach
Bladder
Breast
Colon
Ovary
Liver
Lung
Thyroid
Bone
Skin
Kidney
O r g an
Cancer -4
CancerMortality
MortalityRisk
Riskxx10
10-4per
per1000
1000mGy
mGybybyOrgan
Organ
5.75
5.75%
%per
per1000
1000mGy
mGywhole
wholebody
body
9
Biological Risk vs age
Age (yrs)
10
Patient Dose Risks from CT
11
How do we determine organ dose?
• Model of incident X-ray beam
Incident • Model of patient
X-ray photon • Monte Carlo model of X-ray interactions and energy deposition
Organ
Organdose
doseand
andeffective
effectivedose
dosedata
data
• Difficult to obtain
(University Physics Departments and Regulatory Agencies)
For
Forroutine
routineclinical
clinicaluse
useaaCT
CTDose
DoseIndex
Indexisisemployed
employedas
asan
anindicator
indicatorof
ofdose
dose
and not the actual organ or effective patient dose
and not the actual organ or effective patient dose
12
CTDI - CT Dose Index
• First CT dose index (late 70’s) Reference Phantoms
16 cm dia Head
• Defined by FDA publication 32 cm dia Body Pencil chamber
> 14 cm thick PMMA 100 mm long
21CFR 1020.33 1cm dia
Slice Plane
phantom
FDA
FDArequires
requiresCT
CTmanufacturers
manufacturersto
todisclose
disclosethe
theCTDI
CTDI
for
forstandard
standardhead
headand
andbody
bodyprotocols
protocolsand
andadjustment
adjustmentfactors
factors
13
CTDI measurement
n The CTDI dose is computed
X-ray scatters
according to a formula out of plane within
an object generating
a dose profile in Z
n TLDs are required to measure the
central and peripheral dose profile in
the reference phantom
n However most evaluators do not go 4x1.25 mm CTDI Body Phantom Dose Profile
through this much trouble 50
1 7T
nT −ò50
CTDI 100 = 1
D( z)dz CTDI =
nT ò D( z)dz
−7T
CTDI
CTDIUnderstates
Understatesthe
thedose
dosefor
fornarrow
narrowslices
slices
14
CTDI100 and CTDIW
• CTDI100 and CTDIW are newer IEC standards
• CTDI100 is the dose measured in the CTDI reference
phantom integrated over a fixed 100 mm length
• CTDI100 is computed as the dose absorbed in air not pmma
• Dose in Air is about 11% higher than dose in PMMA
• CTDIw is 2/3 peripheral CTDI100 + 1/3 central CTDI100
• CTDIw provides a convenient index for comparing
scanner dose and patient exposures
CTDI100
CTDI100and
andCTDIw
CTDIware
arebetter
betterindicators
indicatorsof
ofCT
CTdose
dose
15
MSAD - Multiple Scan Average Dose
CTDI adjusted for helical pitch or slice increment
Helical
MSAD
MSADisiscurrently
currentlycomputed
computedand
anddisplayed
displayedas
asan
anadjusted
adjustedCTDIw
CTDIw
16
DLP - Dose Length Product
DLP
DLPis
isaaconvenient
convenientindex
indexfor
fortotal
totalpatient
patientdose
dose
17
Why
Whyshould
shouldwe
wecare
care about
about beam
beam quality?
quality?
Incident 120 kv X-ray spectrum Exit X-ray 120 kv spectrum, 40 cm of Water
Spectrum with
0.15 mm of Cu
Spectrum with
0.15 mm of Cu
keV keV
Unfiltered has 40% higher exposure Unfiltered has 14 % higher exposure
We
Wedon’t
don’twant
wantsoft
softX-ray
X-raythat
thathas
hasvirtually
virtuallyno
noprobability
probabilityof
ofbeing
beingdetected
detected
18
Half Value Layer
X-ray X-ray
• A measure of beam
quality
Aluminum • How much aluminum
filters
(or other material) is
HVL
needed to reduce the
dose by one half
11.2
11.2 5.6
19
Quantity equivalent filtration
Unfiltered Unfiltered
• Measure the dose with X-ray X-ray
aluminum required to
get the same dose
20
Quality equivalent filtration
X-ray X-ray Filtration
• Measure HVL with under test
filtration)
21
Some Major CT Regulations
• FDA 21CFR 1020.33
CTDI, HVL, IQ performance statements
• IEC 601
Overall minimum safety standards (mechanical, S/W, EMC, dose...)
(just meeting the minimum is not a good design!)
• IEC 601-1-3
General X-ray dose
• IEC 61223-2-6
Quality assurance testing for CT
• IEC 601-2-44
All safety for CT, Report CTDIw and dose efficiency on monitor
• IEC 601-1-5 draft - not a released standard
Will set Minimal IQ requirements below stated dose limits
IEC 61223-3-6 draft - not a released standard
Will set standards for CT equipment acceptance testing
• Euratom 97/43 (European Union)
Directive for EU to produce regulations by May 2000 regarding
Use of dose reference guidelines
Maintaining individual, procedure, and equipment dose records
22
Dose Reduction Opportunities
The Radiologist
The CT Manufacturer
Incident patient
X-ray
X-ray
information
Go
Go for
for ALARA
ALARA !!
As
As Low
Low As
As Reasonably
Reasonably Achievable
Achievable 23
The
TheRadiologist
RadiologistALARA
ALARADilemma
Dilemma
Limited
Limitedmeans
meansto
toestimate
estimateand
andadjust
adjustfor
forpatient
patientattenuation
attenuationvariability
variability
24
How
Howvariable
variableis
isthe
thepatient
patientpopulation?
population?
attenuation vs exam
Data from 45 patient Examinations
2500
max atten
2000
min atten
1500 avg atten
1000
500
s/ is
s / is
s/ is
is
l u abs
l u abs
l u abs
bs
s
ng
s
s
ad
ad
s/ d
l u ck
er
ab
ab
ab elv
ab elv
lv
a b elv
a b ea
/a
lu
ne
he
he
pe
ld
/
/
/
h
ng
ng
ng
ng
p
p
ou
sh
In
Insome
somecases
casesaafactor
factorof
of10
10for
forthe
thesame
sameanatomy
anatomy
25
Image
ImageNoise
Noiseis
isstrongly
stronglyinfluenced
influencedby
bypatient
patientattenuation
attenuation
42cm
30cmΦ
Image Noise
25cmΦ
35cm
20cmΦ
15cmΦ
10cmΦ 25cm
26
Auto
AutomA
mA --Required
Requireddose
dosedepends
dependson on
required
requireddiagnostic
diagnosticimage
imagequality
qualityand
andpatient
patientattenuation
attenuation
System calculates
required mA
for consistent IQ
Radiologist/Technologist
Radiologist/Technologistselects
selectsaatarget
targetnoise
noisevalue
valueinstead
insteadofofmA
mA
Repeatable
Repeatablediagnostic
diagnosticimage
imagequality
quality independent
independentofofpatient
patientvariability
variability
27
Auto
AutomA
mAor
or Automatic
AutomaticExposure
ExposureControl
Control
1 5 10 15
250
200
mA
150
Information for mA adjustment
100
can be obtained from scout scans
50
or
in real time from prior projections 0
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
location
Adjusts
Adjuststhe
themA
mAtotoachieve
achieveaaconsistent
consistentdiagnostic
diagnosticquality
quality
Dose
Dosereductions
reductionsof
ofup
upto
to35
35%
%have
havebeen
beenreported
reportedfor
forGE
GELX/i
LX/i
28
Scan Tech. Optimization 2: Patient by Patient
Auto Exposure Control
Adult Head(34 years old) Infant Head(3 weeks old)
412.5mAs 97.5mAs
(275mA x 1.5sec) (65mA x 1.5sec)
Image SD=2.32 Image SD=2.29
Same
Samepediatric
pediatricimage
imagenoise
noiseat
at1/4
1/4the
theadult
adultmA
mA 29
Smart
SmartScan
Scan--Adjusts
AdjustsIncident
IncidentX-ray
X-rayto
toMatch
MatchPatient
PatientShape
Shapevariation
variation
å P (α , β )
2
N x, y =
Dose
Dosereductions
reductionsbeyond
beyond25%
25%are
arepossible
possiblewithout
withoutaasignificant
significantimage
imagenoise
noiseincrease
increase
30
Methods
Methodsof
ofAuto
AutomA
mAand
andSmartScan
SmartScan
Intensity variation
not shown to scale
Auto mA
(LX/i, ZX/I, NX/i)
SmartScan (CT/i)
(fixed modulation)
Auto mA &
SmartScan
(w Z modulation)
Future potential
(continuous Z modulation
per previous views)
Future potential
31
Advantages
Advantagesof
ofaabowtie
bowtiebeam
beamshaping
shapingfilter
filter
Normalized
CTDI body phantom edge dose
vs gantry angle (degrees)
0 deg
Off axis rays
attenuated more
Bowtie filter
by bowtie filter
90 deg
Reduces
Reduces surface
surface dose
dose by
byabout
about 1/2
1/2
32
Multiple
MultipleBowtie
Bowtiefilters
filters(SmartBeam)
(SmartBeam)
Small Large
Bowtie Bowtie
for small for large
anatomy anatomy
uniform uniform
x-ray x-ray
field field
Multiple
Multiple bowtie
bowtiefilters
filterscan
canbetter
bettermatch
matchdose
doseto
topatient
patientanatomy
anatomy
33
Potential
Potentialfor
forCardiac
Cardiac Dose
DoseReduction
Reduction
mA maximum
during systole
Gate the mA
value as a
function
of the R peak mA minimize
elsewhere
AAvariation
variationof
of SmartScan
SmartScan
34
Dose
Dosereduction
reductionimage
imagefilter
filter
Objective:
Objective: Can
Canan
anadaptive
adaptivefilter
filterimprove
improveradiologist
radiologistacceptance
acceptanceof
ofusing
usinglower
lowerdose?
dose?
35
How
Howcan
canthe
theradiologist
radiologistknow
knowwhat
whatisisneeded
neededfor
foraadiagnostic
diagnosticquality
qualityimage?
image?
product
procedure Bulletin Confidential
FAQ’s
Board Chat room
Patient (weight, age)
Radiology
Radiologycommunity
communityshares
sharesprotocols
protocolsand
anddose
dosemetrics
metrics 36
Other ALARA Opportunities we
might consider for the future
37
System Dose Efficiency
Some
SomeSystem
SystemDose
DoseEfficiency
EfficiencyMetrics!
Metrics!
LCD vs dose
ImPACT Q2 factor
System DQE (Dose Quantum Efficiency)
Multislice Z axis dose efficiency
You
Youcan’t
can’tjust
justmeasure
measuredose
doseto
tocompare
comparesystems!
systems!
You
Youmust
mustknow
knowthethedose
doserequired
requiredto
toobtain
obtainaaspecified
specified
image
imagesignal
signalto
tonoise
noiseratio!
ratio!
38
LCD
LCDmeasurement
measurementmethods
methods
Present methods rely on phantoms with fixed patterns and have large observer variability 1 to 2 HU
Human
Image display Observer
LCD Scan Data Processing (film or monitor)
X-ray Phantom
filter
Filtered
Backprojection
Reconstruction
X-Ray
Generator
&
Bowtie Detector
kv, mAs
Filter and DAS
A Statistical LCD method eliminates the large human observer variability about 0.1 to 0.2 HU
Tile image to represent regions with areas True CT# of True CT# of low
of increasing pixel counts. background contrast object
3.29σµ
Compute standard deviation of the means.
We can’t simple reduce the pixel standard
deviation by 1 Distribution of
mean CT#’s of ROI
Distribution of mean
CT#’s of ROI on low
N on background contrast object
AAdose
doseassessment
assessmentwithout
withoutan
anobjective
objectiveLCD
LCDmeasure
measurecan
canbe
bemisleading
misleading
39
Q 2
Q2factor,
factor,ImPACT
ImPACTgroup
groupof
ofUK
UKMDA
MDA
Head Q2 Body Q2
Information from ImPACT Four Slice CT Scanner Comparison Report, Version 3, March 2001
Unused
UnusedX-ray
X-rayfalls
fallsoff
offthe
thedetector
detectorends
endsand
andbetween
betweencell
cellsegments
segments 41
DQE
DQEDose
Dosequantum
quantumEfficiency
Efficiency
Percent of photons detected relative to photons available to be measured
CT Detector Assembly
Flex
Plate and
Photodiode Lumex Wire Grid Carbon
Window
X-Ray X-Ray
Conversion Conversion Transmission of
from Light Transmission
from X-Rays to Carbon window
to Charge of Collimator
Light
Photon
Photontransmission
transmissionin
inaamultislice
multislicedetector
detectormust
mustbe
behigh
high
42
Multislice
MultisliceZZaxis
axisDose
DoseEfficiency
Efficiency
Z-axis Focal spot
thermal movement
X-ray for
image slices
Total X-ray
beam width
total _ image _ slice _ width
Z efficiency = × 100%
total _ Xray _ beam _ width
Percent
PercentofofX-ray
X-rayused
usedfor
forimage
imageslices
slices
relative
relativeto
tototal
total beam
beamwidth
width
43
X-ray
X-rayBeam
BeamTracking
Trackingon
onGE
GELightSpeed
LightSpeed®®
focal
spot
Stepper
Steppermotor
motor
repositions
repositionscam
cam An identical
independent
loop operates
on each side
of the beam to
hold penumbra
Firmware
FirmwareComputes
Computes at detector edge
new
new camposition
cam position
from
from Z cell signalratio
Z cell signal ratio 2A / 1A
See Toth etal , ‘A dose reduction x-ray beam positioning system for high speed multislice scanners’
Medical Physics, December 2000
Beam
BeamTracking
Trackingsignificantly
significantlyimproves
improves
Z-axis
Z-axisdose
doseefficiency
efficiency
44
Multislice
Multislicecollimation
collimationopportunities
opportunitieswith
withtracking
tracking
Extended
Extendedrow
rowandandthin
thinslice
slicetracking
tracking
significantly
significantlyimprove
improveZZaxis
axisdose
doseefficiency
efficiency
45
Geometric
Geometric Efficiency
Efficiency in
in ZZ
Information from ImPACT Four Slice CT Scanner Comparison Report, Version 3, March 2001
Geometric Efficiency in Z
GE
80
VZ
70
MX8000
60
15% potential error band Aquilion
50
40
0.5-0.6 1-1.25 2-2.5 3.8-4 5
Slice
Low
LowDose
Dosemodes
modeswill
willgive
giveus
us95%
95%Efficiency
Efficiencyin
inZZfor
forall
allslices
slices
Low
LowDose
Dosemodes
modesare
arepart
partthe
theGE
GE88Slice
SliceDetector!
Detector!
46
What
Whatisisdone
donefor
forlow
lowsignal
signaldegradation
degradationother
otherthan
thanincrease
increasedose
dose
No projection
filtration
Level 1
filtration Noise contaminated
Level 2
filtration
increased
AAR
AAR- -Advance
AdvanceArtifact
ArtifactReduction
Reduction
AAlevel
level dependent filter that kicks inwhen
dependent filter that kicks in whenprojections
projections
are contaminated by electronic noise
are contaminated by electronic noise
47
Some Myths about LightSpeed and Dose
LightSpeed dose is 20-38 times as much as the EBCT
C-150XP/LXP is 42 mGy Head CTDI , 16 mGy Body CTDI @130 kV, 31 mAs
LightSpeed is 39 mGy Head CTDI, 10 mGy Body CTDI @ 120 kV, 260 mAs
LightSpeed dose is so high that children don't get scanned on the unit
Does anyone really buy this myth?
LightSpeed dose is 50% higher than the single slice dose from CT/i
All multislice scanners are higher but this is wrong, look at the data sheets:
QX/i 0.33% noise in a 20 cm water phantom @ 29 mGy (20%)
CT/i 0.33% noise in a 20 cm water phantom @ 25 mGy
Siemens has better dose than GE in all situations
Look at ImPACT report of March 2001, ‘Four Slice CT Scanner Comparison’
GE Wins!
Dose is higher on GE because the source is closer to the patient (geometry change)
A short geometry allows the mA to be reduced and thereby achieve the
same IQ as long geometry geometry without a dose increase
48
Congratulations