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OPC3 Main Presentation National Convention 2009
OPC3 Main Presentation National Convention 2009
vitamin C in scurvy
• Found that citrus fruits bear other
material stabilizing blood vessels
• Introduced the term vitamin P
for flavonoids
OH
OH
OH
HO O
OH
OH
OH OH
HO O
OH
OH
OH
HO OH
O
HO
OH
OH
The maritime pine tree grows
for 30-50 years in an
unspoiled environment:
no pesticides
no fertilizers
no pollution
mono-culture
no seasonal influence
tomorrow
30 years ago
UV exposure leads to free radical production and inflammation
in the skin producing serious damage to skin cells
100%
Lipids saved from oxidation
80%
60%
40%
20%
0%
vit C lipoic vit E grape Pycnogenol®
acid seed
40%
20%
0%
0 5 10 15 20 25
weeks
Kyriazi et al., Cancer Letters 2005 237: 234-241, 2006
Mean pigmented area size: - 37.7 %
Mean intensity index: - 22.4 %
70
60
Area size [mm2]
50
40
30
20 Hyper-pigmentation
10
0 30 women with hyperpigmentation:
Before After 25 mg Pycnogenol® 3x daily for 30 days
treatment treatment
Enzymes
cell wall
DNA
mitochondria
Enzymes
cell wall
DNA
mitochondria
enzymes
Pycnogenol®
cell wall
DNA
Presence of anti-oxidant enzymes in endothelial cells
after 8 hour exposure to Pycnogenol®
1
baseline 3 and 6 weeks 4 weeks
Pycnogenol® wash-out
Memory improvement
shown after 3 months
NO
arginine NO
NO
+ O2 NO
NO
p<0.05
Increase of 3
antioxidant
impact rate
units/ minute
2
0 10 20 30 40 50 60 70 80 90 2 2½ 3 3½ 4
min min min min min min min min min h h h h h
Cesarone et al., Angiology 2008
Cesarone et al., Angiology 2008
Cesarone et al., Angiology 2008
Cesarone et al., Angiology 2008
Cesarone et al., Angiology 2008