Physical Pharmacy Page 1 of 14

D 1. The buffer equation is also known as:

a. Noyes-Whitney c. Arrhenius
b. Van’t Hoff d. Henderson-Hasselbalch
B 2. The dissolution of a drug is calculated using:
a. Henderson-Hasselbalch c. Arrhenius
b. Noyes-Whitney d. Stokes
A 3. The vapor pressure of a solution _________ by the presence of a solute.
a. lowered c. unaltered
b. raised d. developed
A 4. To increase the miscibility of partially miscible liquids, add a substance,
a. miscible with both liquids c. immiscible with both liquids
b. miscible with one of the liquids d. immiscible with one of the liquids
B 5. The number of moles of solute per liter of solution:
a. normality c. molality
b. molarity d. none of the above
A 6. The number of gram equivalents of solute per liter of solution:
a. normality c. molality
b. molarity d. none of the above
C 7. The number of moles of solute per 1000g of solvent:
a. normality c. molality
b. molarity d. none of the above
B 8. Crystalline form of NaCl:
a. tetragonal c. hexagonal
b. cubic d. monoclinic
A 9. A type of solution where the dispersed phase is uniform throughout the solution:
a. true solution c. coarse dispersion
b. suspension d. colloidal dispersion
B 10. Diffusion mechanism whereby drugs are transported from a region of high to low concentration:
a. active c. facilitated
b. passive d. all of the above
A 11. Diffusion mechanism whereby drugs are transported from a region of low to high concentration:
a. active c. facilitated
b. passive d. all of the above
C 12. An equation which reveals the rate of diffusion of a drug:
a. Noyes-Whitney c. Fick’s First Law
b. Nernst Film Theory d. Fick’s Second Law
D 13. The following statements are true for dustibility are true, except
a. it signifies the opposite of stickness
b. it characterizes the free-flowing powders
c. it has some relation to the uniform spreading of dusting powders when applied
to skin
d. it is a measure of the cohesiveness of particles of a compacted powder
A 14. Complete wetting of a surface occurs when the contact angle between a liquid droplet and the surface is:
a. 0º c. 180º
b. 160º d. 90º
D 15. Gels and magmas when standing form semisolids and on shaking become fluid are said to be:
a. Plastic c. Dilatant
b. Newtonian d. Thixotropic
A 16. The attractive forces between polar molecules, that is, between molecules that possess dipole movement:
a. Keesom Forces c. Van der Waals Forces
b. Dispersion Forces d. Ion-Dipole Forces
C 17. The existence of elemental substances such as carbon and sulfur, in more than one crystalline form:
a. Polymerism c. Polymorphism
b. Isomerism d. Polymorphs
B 18. A method of measuring tonicity which is based on the effect of various solutions of the drug observed on the appearance
of of red blood cells suspending in the solutions:
a. Cryoscopic Method c. Freezing Point Depression Method
b. Hemolytic Method d. NaCl Method
D 19. The effect of pressure on the solubility of a gas is expressed by _______, which states that in every dilute at constant
temperature, the concentration of dissolved gas is proportional to the partial pressure of the gas above the solution at equilibrium:
a. Stoke’s Law c. Newton’s Law
b. Raoult’s Law d. Henry’s Law
B 20. The attractive interaction between a polar molecule and the induces dipole;
a. Ion-Induced Dipole Interaction c. Induced Dipole
b. Dipole-Induced Dipole Interaction d. Ion-Dipole Forces
B 21. The following are not cationic surfactants, except:
a. Potassium Laureate c. Na Lauryl Sulfate
b. Quaternary NH4 compounds d. Triethanolamine Stearate

B 22. The bulk density of a powder depends primarily on the following, except:
a. particle size distribution c. particle shape
b. particle sedimentation d. tendency of the particles to adhere to one another
Physical Pharmacy Page 2 of 14

B 23. When the stressed is removed, a ____ system returns to its original state of fluidity.
a. Plastic c. Pseudoplastic
b. Dilatant d. Newtonian
A 24. An example of liquid-liquid interface.
a. Emulsion c. Mixture
b. Suspension d. Gels
D 25. The degree of adsorption of a gas by a solid depends on the chemical nature of the:
a. adsorbent c. temperature
b. surface area of then adsorbent d. all of the above
C 26. The ff are methods of determining particle size, except;
a. sedimentation c. density
b. optical microscopy d. particle volume measurement
A 27. The ratio of the void volume to the bulk volume of the packing
a. porosity c. bulkiness
b. packing arrangement d. flow properties
C 28. Type of particle density which is determined by the displacement of mercury
a. true density c. granule density
b. bulk density d. void volume
B 29. Kinematic viscosity is also known as:
a. relative viscosity c. fluidity
b. absolute viscosity d. stress
D 30. Viscosity of a pseudoplastic substance decreases with increasing _____________.
a. shearing stress c. pressure
b. temperature d. rate of shear
A 31. As the temperature increases, the solubility of most gases decreases, owing to the greater tendency of the gas to________.
a. expand c. bind
b. diffuse d. scatter
B 32. The following are not organic molecular complexes, except;
a. Clathtrates c. Channel Lattice Type
b. Picric acid type d. Olefin Type
C 33. The following are methods of determining the type of emulsions, except;
a. dye method c. cryoscopic method
b. conductivity test method d. dilution test method
D 34. The change of emulsion type from O/W to W/O or vice versa is known as:
a. coalescence c. creaming
b. breaking d. phase inversion
C 35. Relatively insoluble
a. less than 1 part solute
b. 100-1000 parts solvent
c. more than 10,000 parts of the solvent
d. less than 10,000 parts of the solvent
A 36. The ff are hydrophilic substituents, except:
a. alkyl groups c. hydroxyl group
b. amino group d. carbonyl group
B 37. Molecular weight and mass are examples of _________ property
a. colligative d. none of the above
b. additive e. all of the choices
c. constitutive
A 38. Water is a __________ liquid
a. Newtonian d. dilatant
b. Plastic e. thixotropic
c. Pseudoplastic
B 39. Proposed Law of heat summation
a. Boyle’s Law c. Charles’ Law
b. Hess Law d. Gay Lussac’s Law
B 40. As the length of a non-polar chain of an aliphatic alcohol increases, the solubility of the compoundd in water;
a. increases c. no effect
b. decreases d. all
A 41. Type of reaction wherein the rate is independent of the concentration of reactant or reactants is termed as;
a. zero order reaction c. second order reaction
b. first order reaction d. third order reaction
A 42. The fastest order of reaction to decompose, since according to its differential rate expression, it is independent of the
remaining concentration of the drug after decomposition:
a. zero c. first
b. pseudo-first d. second

B 43. This type of solution has a solute concentration equivalent to its limit of solubility. This would mean that if the same
solute is added to this solution, even in minute amounts, will lead to crystallization, precipitation, or insolubility of that solute:
a. unsaturated solution c. supersaturated solution
b. saturated solution d. none of the above

C 44. Example of constitutive property:

Physical Pharmacy Page 3 of 14

a. mass c. optical activity

b. molecular weight d. temperature
D 45. The increase in mutual solubility of 2 partially miscible solvent by another agent is referred to as:
a. salvation c. miscellar solubilization
b.salting out d. blending
C 46. Number of moles per kilogram solvent:
a. molarity c. molality
b. normality d. percentage expression
C 47. One of these exhibit dilatant flow:
a. cream c. paint
b. ointment d. acacia mucilage
B 48. Which of the following statements is true?
a. solubility increases with increased particle size
b. solubility increases with decreased particle size
c. solubility decreases with increased particle size
d. solubility decreases with decreased particle size
D 49. Ascorbic acid is the least stable of all vitamins. Its instability is via this reaction:
a. photolysis c. none of the choices
b. hydrolysis d. oxidation
D 50. This method of determining the overall order of reaction involves the use of different plots. The plot will form a straight
line that will determine the order:
a. half-life method c. integrated rate method
b. substitution method d. graphical method
C 51. If 1 gram of solute dissolves in 30-100 parts of solvent, the solute is said to be _________ in that solvent:
a. freely soluble d. slightly soluble
b. soluble e. very slightly soluble
c. sparingly soluble
C 52. Method of adjusting the tonicity of a solution to conform that of the blood and lacrimal fluid based on the adjustment of
the freezing point of the solution to –0.52ºC.
a. Sodium chloride equivalent method c. Cryoscopic method
b. White Vincent method d. Sprowls method
C 53. Method of adjusting the tonicity of a solution to conform that of the blood and lacrimal fluid based on the adjustment of
the freezing point of the solution to 0.9% NaCl.
a. Sodium chloride equivalent method c. Cryoscopic method
b. White Vincent method d. Sprowls method
B 54. Method of adjusting the tonicity of a solution to conform that of the blood and lacrimal fluid based on the use of calculated
volume V values when the weight of the drug is 0.3 g, followed by the dilution of this solution with an already isotonic, usually
buffered solution to the appropriate volume.
a. Sodium chloride equivalent method c. Cryoscopic method
b. White Vincent method d. Sprowls method
C 55. Equation showing the buffer capacity of a solution
a. Raoult’s Law c. Van Slyke Equation
b. Stoke’s Law equation d. Vant Hoff’s equation
A 56. Using White-Vincent Method, compute for the required volume to make 0.3 g of Atropine sulfate (E=0.13) isotonic.
a. 4.3 ml c. 25.6 ml
b. 3.9 ml d. 33.3 ml
C 57. Maximum buffer capacity can be observed in a buffer solution with
a. pH lesser than pKa c. pH equals pKa
b. pH greayer than pKa d. pKa greater than pH
A 58. Complexation which involves entrapment of one compound in the molecular framework of another
a. inclusion c. true bond complexation
b. chelation d. charge transfer complexation
B 59. Group which donate electron pair to a central atom to form the coordinate complex
a. metal substrate c. chromophore
b. ligand d. tautomer
C 60. Maximum number of atoms or groups that can combine in the coordination sphere with the central atom
a. Ionization number c. Coordination number
b. Central atom number d. Valence number
D 61. The suppression of a property or reaction of a metal without the removal of that metal from the system
a. coordination c. sensitization
b. stabilization d. sequestration
C 62. Type of complexation involved in Warfarin sodium USP
a. chelation c. Clathrate formation
b. Channel lattice type d. Monomolecular inclusion
B 63. Type of complexation involved in Starch-Iodine Complex
a. chelation c. Clathrate formation
b. Channel lattice type d. Monomolecular inclusion
A 64. Type of complexation involved in Calcium-EDTA Complex
a. chelation c. Clathrate formation
b. Channel lattice type d. Monomolecular inclusion
Physical Pharmacy Page 4 of 14

A 65. 0.75% Sodium chloride aqueous solution is

a. hypotonic c. hypertonic
b. isotonic d. isoosmotic
A 66. When the rate of the reaction is proportional to the first power of the concentration of one reactant, the reaction order is:
a. zero order c. second order
b. first order d. third order
B 67. The force of attraction between molecules of different phases is referred to as:
a. electrostatic force c. cohesive force
b. adhesive force d. van der waal’s force
C 68. The force of attraction between molecules of same phases is referred to as:
a. electrostatic force c. cohesive force
b. adhesive force d. van der waal’s force
A 69. Range of HLB value in the Griffin Scale for anti-foaming agents
a. 1-3 c. 8-16
b. 3-8 d. 16-18
D 70. Range of HLB value in the Griffin Scale for solubilizing agents
a. 1-3 c. 8-16
b. 3-8 d. 16-18
B 71. Range of HLB value in the Griffin Scale for W/O emulsifying agents
a. 1-3 c. 8-16
b. 3-8 d. 16-18
B 72. A colloidal system in which the colloidal particles shows little attraction for the dispersion medium
a. Lyophilic c. Hydrophilic
b. Lyophobic d. Association
C 73. The breaking up of aggregates brought about by the addition of deflocculating agents
a. condensation c. peptization
b. lyophilic dispersion d. association
C 74. Which of the following is an example of an association colloid?
a. Carboxymethylcellulose c. anionic surfactant
b. Bentonite d. acacia
B 75. Colloidal dispersion which is unstable, irreversible and forms nonspontaneously
a. lyophilic dispersion c. Association colloid
b. lyophobic dispersion d. lipophilic dispersion
A 76. The concentration of surfactant’s monomer to bring about micelle formation
a. Critical Micellar Concentration c. Critical Monomer Concentration
b. Aggregation number d. monomer number
C 77. The ability of surfactants to enhance the solubility of insoluble compounds in the dispersion medium
a. Micallization c. Solubilization
b. Flocculation d. Stabilization
B 78. The protective effect of a colloid is expressed in terms of:
a. Schulze-Hardy Rule c. Lyotropic series
b. Gold number d. sedimentation volume
A 79. The upward movement of dispersed droplets relative to the continuous phase
a. creaming c. aggregation
b. sedimentation d. coalescence
A 80. The natural shrinking of gel caused by coarsening of the matrix
a. syneresis c. swelling
b. bleeding d. imbibition
D 81. The taking up of liquid by a gel without the significant change in its volume
a. syneresis c. swelling
b. bleeding d. imbibition
B 82. The liberation of oil or water from ointment base resulting from a deficient gel structure
a. syneresis c. swelling
b. bleeding d. imbibition
C 83. The significant increase in the volume of a gel caused by the addition of interpenetrating liquid
a. syneresis c. swelling
b. bleeding d. imbibition
B 84. An expression of the resistance of a fluid flow
a. fluidity c. stiffness
b. viscosity d. elasticity
B 85. Unit used to express absolute viscosity
a. no unit c. stokes
b. poise d. dynes/cm
A 86. Unit used to express relative viscosity
a. no unit c. stokes
b. poise d. dynes/cm
C 87. Unit used to express kinematic viscosity
a. no unit c. stokes
b. poise d. dynes/cm
A 88. Which of the ff. flow system shows a yield value?
a. plastic c. Newtonian
b. Pseudoplastic d. Dilatant
Physical Pharmacy Page 5 of 14

A 89. In which of the ff. systems does the rheogram plot does not pass through the origin?
a. plastic c. Newtonian
b. Pseudoplastic d. Dilatant
B 90. Which of the ff. systems is referred to as “shear thickening”?
a. plastic c. Newtonian
b. Pseudoplastic d. Dilatant
D 91. Which of the ff. systems is referred to as “shera thinning”?
a. plastic c. Newtonian
b. Pseudoplastic d. Dilatant
C 92. The comparatively slow recovery of the consistency of a material lost through shearing defines
a. Rheopexy c. Thixotropy
b. Dilatancy d. Negative thixotropy
A 93. Cup and Bob Viscometer type where the bob is rotated
a. Searle type c. Cone and Plate type
b. Couette Type d. Oswald type
C 94. Flow of a liquid out from a capillary obeys
a. Stoke’s Law c. Poiseulle’s Law
b. Hooke’s Law d. Graham’s Law
C 95. Which of the ff. forms of radiation is the most penetrating?
a. alpha radiation c. Gamma radiation
b. beta radiation d. electron radiation
A 96. Atoms of different elements having the same number of neutrons
a. isotones c. isomers
b. isobars d. isotopes
B 97. Equation that gives the relationship between the vapor pressure and the absolute temperature of a liquid
a. Raoult’s Law c. Van Slyke equation
b. Clausius-Clapeyron Equation d. vant Hoff’s equation
D 98. Surfactants are
a. lipophiles c. hyophiles
b. hydrophiles d. ampiphiles
D 99. The concentration of a gas, liquid or solid on the surface of a liquid or solid is;
a. solubility c. absorption
b. diffusion d. adsorption
C 100. An isotonic solution has the same;
a. pH as the blood c. salt content as the blood
b. fluid pressure as the blood d. salt content as the blood
D 101. Colligative property/ies;
a. osmotic pressure c. elevation of boiling point
b. lowering of vapor pressure d. all of the above
A 102. This is adjusted to assure stability of liquid pharmaceuticals
a. pH c. Osmolarity
b. lowering of vapor pressure d. all of the above
D 103. Solution in which the solute is in equilibrium with the solid phase
a. unsaturated c. supersaturated
b. subsaturated d. saturated
C 104. This is not true about physical adsorption;
a. reversible
b. adsorbate can be removed from the adsorbent
c. irreversible
d. recognized as Van der Waal’s adsorption
A 105. Two liquids which dissolved in each other in all proportions are said to be:
a. completely miscible c. partially miscible liquids
b. immiscible d. slightly miscible
C 106. States that under the same conditions of temperature and pressure, the spread of diffusion of two different gases are
inversely proportional to the square roots of their densities.
a. Charles’ Law c. Graham’s Law
b. Boyle’s Law d. Ideal Gas Law
A 107. The Avogadro’s number is equal to:
a. 6.02 x 1023 c. 9.6 x 1022
23
b. 1.802 x 10 d. 6.0 x 1023
A 108. Osmotic pressure is:
a. colligative c. additive property of solution
b. constitutive d. accumulative
C 109. The law that governs all reversible reaction is:
a. Boyle’s Law c. Law of Chemical Equilibrium
b. Dalton’s Law d. Law of Conservation of Mass
B 110. Logarithm of the reciprocals of the hydrogen ion concentration:
a. mole c. millimole
b. pH d. pKa
B 111. Two liquids which are completely insoluble with each other are:
a. soluble liquids c. partially miscible liquids
Physical Pharmacy Page 6 of 14

b. immiscible liquids d. NOTA

D 112. The law that gives the relation of volume and temperature at constant pressure:
a. Boyle’s Law c. Dalton’s Law
b. Gay-Lussac’s Law d. Charles’ Law
A 113. Gases are composed of discrete particles called:
a. molecules c. protons
b. electrons d. atom
A 114. The number of grams of solute in 100 gram of solution:
a. percent by weight c. molarity
b. molality d. gram weight
C 115. The decomposition of a solute by electricity is known as:
a. hydrolysis c. electrolysis
b. crystallization d. synthesis
C 116. A colligative property:
a. molality c. freezing point depression
b. molecular weight d. boiling point depression
A 117. Amount whose mass in gram is equal to the atomic weight of the element:
a. gram-atom c. molecular weight
b. mole d. milliequivalent
A 118. the type of chemical bond where atoms share electrons is called:
a. covalence c. electo-valence
b. electrovalent d. electrovalence
C 119. A polar molecule, one region of which is positive and the other negative is called:
a. covalent c. dipole
b. electrovalent d. ionic
C 120. the pressure required to liquefy a gas at its critical temperature:
a. vapor pressure c. critical pressure
b. osmotic pressure d. critical temperature
C 121. For gases the reference substance used to determine the specific gravity is:
a. water c. air
b. carbon dioxide d. oxygen
B 122. The law that governs the relationship between pressure, volume and temperature of gases which is expressed in the
following questions, PV=nRT
a. Boyle’s Law c. Charles’ Law
b. Ideal Gas Law d. Gay-Lussac’s Law
B 123. The above law can be used to determine the ______ of gas
a. atomic weight c. avogadro’s number
b. molecular weight d. mass number
D 124. According to Poiseville equation, the factor that has relatively greatest influence on the rate of flow of liquid through a
capillary tube is the:
a. length of tube c. temperature of liquid
b. viscosity of liquid d. radius of the tube
B 125. The vapor pressure of a liquid
a. decreases with an increase in temperature
b. equals atmospheric pressure at liquid’s boiling point
c. is independent of temperature
d. increases when a solute is added to the liquid
B 126. Sublimation is transformation of matter from;
a. solid to liquid state c. liquid to vapor state
b. solid directly to vapor d. vapor to liquid state
B 127. That portion of energy of a system which cannot be converted to work:
a. enthalpy c. heat potential
b. entropy d. convertibility
B 128. The normal body temperature is 37ºC. What is 37ºC in degrees Fahrenheit?
a. 96.8ºF c. 28.3ºF
b. 98.6ºF d. 199ºF
A 129. The presence of this substance in a formulation enhances the absorption of the active drug
a. surface active agents c. protein
b. fat d. carbohydrate
D 130. The ff. statements are true for HLB system, except;
a. more hydrophilic surfactants have high HLB numbers
b. more lipophilic surfactants have low HLB numbers
c. hydrophilic surfactants from o/w emulsions
d. lipophilic surfactants (Spans) are hydrophobic, emulsion is w/o
A 131. Benzalkonium chloride is a/an;
a. cationic surfactant c. non-ionic surfactant
b. anionic surfactant d. chelating agent
D 132. The ff. are emulsifying agent, except;
a. benzalkonium chloride c. Na Lauryl sulfate
b. cholesterol d. Na sulfate
C 133. This statement is not true:
Physical Pharmacy Page 7 of 14

a. o/w emulsion is miscible with water c. w/o emulsion is miscible with water
b. o/w emulsion conducts electricity d. o/w emulsion is miscible with water

C 134. This is not a surfactant;

a. Mr. Clean c. NaOH
b. Breeze d. Tween 80
A 135. Solutions which have the same freezing point depression and the same vapor pressure are:
a. isotonic c. hypertonic
b. hypotonic d. NOTA
A 136. Lacrimal Fluid has an isotonicity values corresponding to that of NaCl solution with the strength of:
a. 0.9% c. 0%
b. 1.0% d. 0.1%
A 137. Sodium chloride equivalents are used to estimate the amount of NaCl needed to render a solution isotonic. The E may
be defined as:
a. amount of NaCl that is theoretically equivalent to one gram of specified chemical
b. equivalent to salt to make it isotonic
c. equivalent to NaCl which is enough to make it a normal saline
d. equivalent to NaCl is enough to make an ophthalmic solution
C 138. How many mg of NaCl should be present in the following formula to obtain an isotonic solution? (E cocaine HCl is 0.16)
Cocaine HCl 2.0%
NaCl q.s.
a. 48 mg c. 174 mg
b. 96 mg d. 222 mg
A 139. How much NaCl is needed to adjust the following Rx to isotonicity? (E ZnSO4=0.15)
Rx ZnSO4 1%
NaCl q.s.
Purified H2O qs 60 ml
a. 0.45 g c. 0.60 g
b. 0.54 g d. 0.75 g
B 140. In a first order reaction t ½ (half life)
a. is a constant independent of dose
b. can be calculated from the formula 0.693/k
c. changes, depending upon initial concentration
d. is a constant increasing rate
C 141. The biological half-life of a drug that is eliminated by 1st order is mathematically represented by ______, whose k is the
1st order for elimination.
a. 1/k c. 0.693/k
b. log k d. 2.303/k
C 142. Solubility of a substance in a solvent may be expressed in several ways. When a quantitative statements of solubility is
given in the USP, it is generally expressed as:
a. g of solute soluble in 1 ml of solvent
b. g of solute soluble in 100 ml of solvent
c. ml of solvent required to dissolve 1 g solute
d. ml of solvent required to dissolve 100 g of solute
B 143. Reaction rate is increased most readily by
a. humidity c. freezing
b. high temperature d. photolysis
D 144. Dissolution rate is increased by;
a. formation of molecular aggregates c. a decrease in partial size
b. an increase in surface area d. b and c only
A 145. If a buffer solution is prepared using equal concentration of acetic acid and sodium acetate, the pH would then be;
a. equal to pKa c. 14
b. equal to ½ of the pKa d. equal to double the pKa
B 146. Mixing a hypertonic solution with red blood cells will cause _______ of the red blood cells
a. bursting c. chelation
b. crenation d. hemolysis
A 147. A second method for adjusting solution to isotonicity is based upon
a. freezing point depression c. milliequivalent calculation
b. blood coagulation time d. boiling point elevation
B 148. Gases may be liquefied through the following, except:
a. lowering the temperature c. applying pressure
b. increasing the temperature d. condensation
A 149. The sum of the atomic group and bond refractions in a molecule
a. molar refraction c. refractive index
b. specific rotation d. none of the above
C 150. Required temperature for the specific gravity determination
a. 15.56º c. 25º
b. 30º d. 20º
B 151. An increase in temperature ________ the surface tension of a liquid
a. increases c. enhances
b. decreases d. doesn’t change
D 152. Optically active substances are
Physical Pharmacy Page 8 of 14

a. capable of turning the plane of polarized light c. with a unit of mL/n

b. either dextrorotatory or levorotatory d. none of the above

A 153. This is used to measure optical activity specifically the angle of rotation
a. polarimeter c. viscometer
b. refractometer d. hydrometer
A 154. The reciprocal of specific volume
a. specific gravity c. specific rotation
b. specific refraction d. any of the above
B 155. A liquid with relative viscosity value of more than one is:
a. less viscous than water c. as viscous as water
b. more viscous than water d. NOTA
A 156. This is the surface tension between two liquids
a. interfacial tension c. adhesional force of attraction
b. cohesional force of attraction d. AOTA
D 157. The most stable surface active agents
a. anionics c. amphoterics
b. cationics d. nonionics
B 158. Surfactants with high HLB numbers are
a. lipophilic c. either a or b
b. hydrophilic d. neither a nor b
B 159. Hydrophilic surfactants can form
a. w/o emulsions c. either a or b
b. o/w emulsions d. neither a nor b
C 160. These are substances whose molecules and ions move of their own accord to the interface to low surface tension
a. surfactants c. either a or b
b. surface active agents d. neither a nor b
A 161. Surfactants that are used as w/o emulsifying agents have
a. low HLB values c. either a or b
b. high HLB values d. none of the above
D 162. Methods of determining surface tensions, except;
a. ring method c. drop weight method
b. capillary rise method d. none of the above
D 163. Give/s the temperature-volume relationship of gases at constant pressure
a. Combined Gas Law c. Boyle’s Law
b. Avogadro’s Law d. Charles’ Law
A 164. Law of stress and strain
a. Le Chatelier’s Principle c. Law of Conservation of Energy
b. Law of Mass Action d. NOTA
D 165. The ff. are true of electrolytes
a. colligative properties are higher than non electrolytes
b. conduct electricity
c. dissociate to form ions
d. AOTA
D 166. The ff. can decrease the rate of chemical reaction, except;
a. high energy of activation c. high temperature
b. presence of negative catalyst d. any of the above
D 167. Concentration versus time is linear
a. First Order reaction c. Third Order reaction
b. Second Order reaction d. Zero Order reaction
D 168. The ff. statements are true of first order reaction
a. the rate of the reaction depends on the concentration of the reactant raised to the first power
b. half life = 0.693/k
c. Drug ========= product
d. AOTA
C 169. Emulsions made with Spans are usually
a. unstable c. w/o
b. o/w d. reversible
B 170. This method makes use of the tonicity equivalent
a. “D” method c. White-Vincent Method
b. E method d. Sprowl’s Method
A 171. With RBC, a hypotonic solution will
a. cause hemolysis c. cause hemolysis and crenation
b. cause crenation d. neither cause hemolysis nor crenation
C 172. With the lacrimal fluid, a hypertonic solution will
a. cause hemolysis c. cause crenation
b. cause hemolysis and crenation d. neither caus ehemolysis nor crenation
D 173. With the physiologic fluid, an isotonic solution will
a. cause hemolysis c. cause crenation
b. cai=use hemolysis and crenation d. neither cause hemolysis nor crenation
A 174. Solutions of lower osmotic pressure than that of the body fluid are;
a. hypotonic c. isotonic
Physical Pharmacy Page 9 of 14

b. hypertonic d. NOTA
B 175. This is the accepted freezing point of the blood serum and the lachrymal fluid
a. 0.52ºC c. 0ºC
b. -0.52ºC d. NOTA
C 176. This is force per unit area
a. velocity c. pressure
b. acceleration d. work
A 177. Raoult’s Law is encountered in the determination of:
a. Vapor pressure c. Freezing Point
b. Boiling Point d. Osmotic Pressure
D 178. The temperature at which the vapor pressure is equal to the atmospheric pressure
a. freezing point c. critical point
b. melting point d. boiling point
D 179. Sublimation is transformation of matter from
a. solid to liquid state c. vapor to liquid state
b. liquid to vapor state d. solid directly to vapor state
A 180. The anode is the
a. + electrode c. neutral electrode
b. – electrode d. NOTA
C 181. Dispersed systems possess this property
a. optical activity c. thixotropy
b. solubility d. tonicity
A 182. Yield value is the term used to denote
a. the force at which the flow begins c. the behavior of Newtonian fluid
b. the thixotropic nature of a substance d. AOTA
D 183. Most stable and most compatible surfactants in pharmaceutical preparations
a. anionics c. amphoterics
b. cationics d. non ioniocs
B 184. A physician needs 60 ml of an isotonic solution of 2% Tetracaine HCl. How many mg of NaCl should be included in
the formula? E Tetracaine HCL is 0.18
a. 160 mg c. 270 mg
b. 324 mg d. 540 mg
C 185. The ultimate separation of the two phases in an emulsion system is;
a. coalescence c. cracking
b. aggregation d. creaming
D 186. Factors that influence the rate of reaction include:
a. presence of catalysts c. concentration
b. temperature d. AOTA
C 187. Density is derived quantity that combines
a. volume and length c. mass and volume
b. mass and weight d. mass and pressure
B 188. The statement of expiration date assures the patient
a. Absence of toxicity c. complete absorption of drug
b. full therapeutic efficacy d. absence of interaction
A 189. An ideal gas is characterized by the complete ________ of attractive forces between molecules
a. absence c. uniformity
b. homogeneity d. diffusion
C 190. Tweens are surfactants derived from the esters of
a. polyvinyl alcohol c. sorbitant
b. methyl cellulose d. propylene glycol
B 191. A proton accepting solvent is
a. aprotic c. amphiprotic
b. protophilic d. protogenic
D 192. A proton donating solvent is
a. aprotic c. amphiprotic
b. protophilic d. protogenic
D 193. One of the ff. is a synthetic surfactant
a. acacia c. gelatin
b. bentonite d. sorbitan
C 194. A Swedish scientist who formulated the first theory of Ionization
a. Van’t Hoff c. Arrhenius
b. Raoult d. Newton
C 195. This gives the direct opportunity between shear stress and rate of shear
a. Raoult’s Law c. Amagat’s Law
b. Newton’s Law d. Dalton’s Law
B 196. This is shelf-life plus date of manufacture
a. half life c. quarantine time
b. expiration time d. NOTA
B 197. Given identical concentrations, this solution will show the greatest osmotic pressure
a. magnesium sulfate c. Potassium chloride
b. Ferric chloride d. Sodium chloride
B 198. The amount of the substance whose mass in grams is numerically equal to the molecular weight of the substance is called
Physical Pharmacy Page 10 of 14

a. gram atom c. mass number

b. mole d. molecule

A 199. P1V1=P2V2 is the algebraic representation of

a. Boyle’s Law c. Dalton’s Law
b. Charles’ Law d. Amagat’s Law
A 200. This law states that under the same conditions of temperature and pressure, the speed of diffusion of two different gases
are inversely proportional to the square roots of their densities
a. Graham’s Law c. Dalton’s Law
b. Charles’ Law d. Amagat’s Law
A 201. The simplest of solutions
a. gas in gas b. liquid in liquid
b. solid in liquid d. gas in liquid
D 202. Colligative properties depend upon the
a. size of the particles in solution c. type of particle in solution
b. pH of the solution d. number of particles in solution
D 203. Of the colligative properties, this has the greatest importance in pharmaceutical practice
a. boiling point c. vapor pressure
b. freezing point d. osmotic pressure
A 204. This is the number of solute in 100 grams of the solution
a. percent by weight c. molarity
b. molality d. normality
A 205. A 20% solution by weight has
a. 20 g of solute and 80 g of solvent
b. 20 g solute and 100 g of solvent
c. 20 g of solute and 100 ml of solvent
d. NOTA
A 206. The other term for boiling
a. ebullition c. distillation
b. evaporation d. sublimation
B 207. Amount of heat needed at the boiling point to cause the vaporization of 1 g of substance
a. molar heat of vaporization c. molal heat of vaporization
b. specific heat of vaporization d. any of the above
C 208. One part of the solute dissolving in 1-10 parts of solvent is
a. soluble c. freely soluble
b. very soluble d. insoluble
A 209. This is used in separating highly viscous mixtures.
a. centrifugation c. distillation
b. filtration d. NOTA
A 210. The process by which finely divided solids and colloidal materials are separated from liquids without the use of filter is
a. clarification c. centrifugation
b. sedimentation d. NOTA
C 211. In colloidal dispersion, the dispersed system is called
a. dispersion medium c. internal phase
b. vehicle d. external phase
C 212. Freeze drying is called
a. stabilization c. lyophilization
b. vacuum freezing d. solubilization
B 213. The degradation reaction of aspirin involves:
a. epimerization c. isomerization
b. hydrolysis d. oxidation
B 214. It refers to the time required for 50% of the drug to be decomposed
a. expiration date c. shelf life
b. half life d. N OTA
A 215. A naturally occurring chelate involved in life processes:
a. chlorophyll c. Polymer
b. Carboxymethylcellulose d. Povidone
C 216. The half life equation for a first order reaction is
a. a/2k c. 0.693/k
b. 1/ak d. a/ak
A 217. The boundary between two phases is termed as:
a. interface c. both a and b
b. surface d. NOTA
B 218. The principles of solid-liquid adsorption are utilized in the ff. processes. Except;
a. adsorption chromatography c. detergency
b. foaming d. wetting
B 219. Compounds/mixtures of compounds that by their presence in solution, resist changes in pH;
a. organic compounds c. inorganic compound
b. buffers d. NOTA
A 220. An example of buffer pair:
a. Boric acid- sodium borate c. Hydrochloric acid-sodium chloride
Physical Pharmacy Page 11 of 14

b. Na hydroxide- Ammonium chloride d. any of the above

A 221. Atoms of the same element having the same atomic number but different mass number;
a. isotope c. protons
b. molecules d. electrons

C 222. The unit of surface tension is

a. poise c. dyne/cm
b. calorie d. joule
D 223. PV=nRT is the mathematical expression for:
a. Boyles Law c. Claussius Clapeyron equation
b. Charles’ Law d. Ideal Gas Law
C 224. The gram-molecular volume of a gas at STP is equal to:
a. 1.0 L c. 22.4 L
b. 2.24 L d. 22.4 ml
C 225. The properties of matter are usually expressed by the use of the ff quantities, except;
a. length c. density
b. mass d. time
A 226. The standard of mass is;
\ a. kilogram c. density
b. pounds d. specific
C 227. When a gas is cooled, it loses some of its kinetic energy in the form of heat, the velocity of the molecules;
\ a. increases c. decreases
b. not changed d. a and c
C 228. Specific gravity is the ratio of the;
a. density of the substance to that of alcohol
b. density of an oil to that of a substance
c. density of a substance to that of water
d. a and b
B 229. As to phase equilibrium, a system containing water and its vapor is considered as:
a. one phase system, c. three phase system
b. two phase system d. a and c
D 230. The physical properties of a solution/substance may be classified
a. colligative c. constitutive
b. additive d. compositive
A 231. A mixture of two or more components that form a homogeneous molecular dispersion forming a one phase system is:
a. true solution c. colloidal dispersion
b. coarse dispersion d. a and c
C 232. Substances that do not yield ions when dissolved in water and not conduct electric current through the solutions are;
a. electrolytes c. non electrolytes
b. solutes d. solvents
D 233. The temperature at which a pure liquid and solid exist in equilibrium is:
a. freezing point c. melting point
b. boiling point d. a and c
C 234. Interfacial phenomena in pharmacy and medicine are significant factors that affect the ff processes, except:
a. adsorption of drugs onto solid adjuncts
b. penetration of molecules through biologic medium
c. penetration of aqueous solution
d. emulsion formulation and formulation stability
C 235. Common method of determining particle size is, except
a. microscopy c. precipitation
b. sieving d. sedimentation
C 236. Rheology involves the study of:
a. description of the flow of liquids c. a and b
b. deformation of solids d. description of physical property of a substance
D 237. Body Fluid/s with freezing point of -0.52ºC is:
a. human blood c. saliva
b. lachrymal fluid d. a and b
D 238. Phenomenon applied to adsorption at solid surfaces is;
a. wetting property c. foaming property
b. detergency d. a and b
A 239. Resistance of a liquid to flow is:
a. viscosity c. suspendability
b. fluidity d. b and c
A 240. The science and technology of small particles
a. micromeritics c. microbiology
b. micronization d. microfiltration
B 241. Most effective means of sterilization at low temperature is;
a. dry heat c. tyndallization
b. moist heat d. inspissation
B 242. Volume occupied by the powder itself using a cylinder is;
a. void volume c. powder density
b. bulk volume d. true volume
Physical Pharmacy Page 12 of 14

A 243. Science which deals with the study of the relationship between heat and energy is;
a. thermodynamics c. thermophilic
b. thermokinetics d. thermal energy
B 245. Volume of the spaces between the particles of a powder is called;
a. bulk c. density
b. void d. a and b
A 246. Property of liquid systems that gels in the container but becomes fluid upon shaking is;
a. thixotropy c. diffusibility
b. dispersibility d. a and b
A 247. The following rheologic systems show a change in viscosity with a change in shear rate, except;
\ a. Newtonian c. dilatant
b. Plastic d. Pseudoplastic
D 248. Matter has a definite shape when it is:
a. liquid c. gas
b. mixture d. solid
B 249. Relationship between the buffer capacity of the buffer with the molar concentration of the components is;
a. inversely proportional c. not related
b. directly proportional d. equal
A 250. Size of colloidal dispersions compared to the size of molecules of solute in true solutions are;
a. larger c. smaller
b. same d. a and c
A 251. The ff. combinations are completely miscible, except;
a. water and ether c. alcohol and acetone
b. water and alcohol d. glycerin and refined alcohol
D 252. These substances form colloidal solutions, except;
a. albumin c. acacia
b. polyvinyl pyrrolidone (PVP) d. Na Lauryl Sulfate
A 253. The zigzag movement of colloidal particles
a. Brownian movement c. diffusion
b. tyndallization d. light scattering
B 254. One method used to adjust tonicity of a solution is by;
a. dilution c. adding a minimum amount of salt
b. cryoscopic d. a or b
D 255. The freezing point of a human blood is the same as:
a. tears c. gastric fluid
b. 0.9% NaCl d. a and b
B 256. Polymorphism is the presence of a drug in the ff number of crystalline forms;
a. one c. less than one
b. two d a and b
A 257. Bodies that exhibit plastic flow in non-Newtonian system is known as:
a. Bingham bodies c. coarse particles
b. Newton bodies d. b and c
A 258. The Liso of a drug is its molar concentration that will attain isotonicity based on;
a. freezing point depression of -0.52ºC
b. boiling point of 100ºC
c. melting point of 0ºC
d. any of the above
D 259. Ultrafiltration is similar to:
a. press filtration c. filtration using an ashless filter paper
b. asbestos pad filtration d. reverse osmosis
A 260. Most drugs are:
a. weak electrolytes c. non electrolytes
b. strong electrolytes d. highly ionic
B 261. For some drugs, the rate of solution is increased by:
a. freezing c. humidity
b. high temperature d. photolysis
C 263. Raoult’s Law is applied to the determination of:
a. boiling point c. vapor pressure
b. osmotic pressure d. freezing point
D 264. Powder fineness may be measured by:
a. spectroscopy c. sieve analysis
b. microscopy d. b and c
A 265. Decrease in viscosity is caused by:
a. increase in temperature c. increase in tonicity
b. decrease in temperature d. increase in pH
C 266. The process which involves vaporization and then condensation is
a. crystallization c. fusion
b. sublimation d. freezing
C 267. To increase solubility of endothermic substance
a. dissolve with the aid of ice c. apply heat during the process of dissolving
b. dissolve at room temperature d. NOTA
A 268. The dissolution rate apparatus consist of the following parts except;
Physical Pharmacy Page 13 of 14

a. basket rack assembly c. with a sampling tube

b. paddle as stirring device d. constant temperature bath
A 269. Example of additive property;
a. molecular weight c. electrolyte example
b. atomic weight d. ions present

C 270. Characteristics of an ideal solution:

a. reaction between substances present during storage
b. heat is evolved upon mixing the ingredients
c. no heat is evolved or absorbed during mixing
d. evaporation takes place upon storage.
B 271. Characteristics of a lyophobic substance;
a. easily wet by water c. easily wet by hydroalcohol
b. easily wet by a non polar solvent d. a and c
A 272. Dilatant flow is applicable to systems which;
a. increase in volume when stress is applied
b. decrease in volume when stress is applied
c. no change in volume when stress is applied
d. a and b
B 273. Thixotropy is a characteristic of gels which is:
a. hardens upon standing and after agitation
b. hardens upon standing but liquefies upon agitation
c. liquefies upon standing and after agitation
d. a and b
C 274. A system having a particle size that is intermediate between a true solution and a coarse dispersion, roughly 10-5000
angstrom is:
a. system c. colloidal dispersion
b. phase d. solution
B 275. The passage of a solvent into a solution through a semipermeable membrane is:
a. diffusion c. fractional distillation
b. osmosis d. microfiltration
A 276. Chelates belong to the same class of complexes known as:
a. metal complexes c. molecular complexes
b. ion-exchange compounds d. no bond complexes
C 277. This Law stresses that the higher the viscosity of a liquid, the greater the force per unit area (shearing stress) required to
produce a certain rate of shear:
a. rheology c. Newtonian Law of Flow
b. viscosity d. Non-Newtonian system
B 278. Plastic flow is associated with the presence of:
a. plastic materials c. deflocculated particles
b. flocculated particles d. a and c
D 279. What is the law which states that an acid is a substance that is capable of donating a proton, while a base is a substance
that is capable of accepting proton from an acid?
a. Faraday’s Law c. Debye and Huckle theory
b. Henry’s Law d. Bronsted-Lowry theory
A 280. He established the term “pH” and formulated the pH scale
a. Sorensen c. Henry
b. Debye d. Faraday
A 281. A solution in which there is no change in the property of components other than dilution when they are mixed:
a. ideal solution c. relative solution
b. true solution d. suspension
A 282. The first theory of ionic solution was prepared by _______ in 1887. He was also the one who formulated the theory of
electrolytic dissociation:
a. Arrhenius c. Raoult
b. Henry d. Morse
A 283. The total number of atoms in the molecule or the sum of the constituents in the solution is known as:
a. additive c. colligative
b. constitutive d. a and b
B 284. A property that depends on the arrangement to a lesser extent on the number and kinds pf atoms within the molecule:
a. additive c. colligative
b. constitutive d. summative
B 285. The migration of colloidal particles between the electrodes is:
a. dialysis c. tyndall effect
b. electrophoresis d. a and b
B 286. Decrease in solubility of non electrolyte by the addition of an electrolyte results in
a. separation c. hydrolysis
b. salting out d. reduction
A 287. The frictional forces in a loose powder can be measured by the:
a. angle of repose c. Hausner’s ratio
b. Carr’s compressibility index d. Any of the above
B 288. “Solvent-hating” colloidal system
Physical Pharmacy Page 14 of 14

a. lyophilic c. ampiphilic
b. lyophobi d. NOTA
A 289. Mayonnaise is an example of:
a. emulsion d. gel
b. suspension e. None of the choices
c. sol

B 290. Type of solution (based on forces of attraction) where there is complete uniformity of attractive forces:
a. real d. electrolyte
b. ideal e. non electrolyte
c. colligative
C 291. Migration of solute from a greater concentration to a lower concentration:
a. disintegration d. active transport
b. dissolution e. none of the choices
c. diffusion
A 292. This type of emulsion is transparent in character:
a. microemulsion c. simple emulsion
b. multiple emulsion d. AOTA
B 293. Spans are used for what type of emulsion?
a. simple o/w c. multiple
b. simple w/o d. microemulsion
C 294. Dipole-dipole interaction
a. ionic d. debye forces
b. covalent e. London forces
c. keesom forces
B 295. Ionization of a salt or formation of charged ions:
a. ion-induced dipole c. hydrogen bonding
b. ion dipole d. AOTA
B 296. The NaCl equivalent of ZnSO4 is 0.1. This means that
a. 1.0 g of NaCl represents 0.16 g ZnSO4
b. 0.16 g Na Cl is equivalent to 1 g ZnSO4
c. 0.16 g NaCl is equivalent to 0.16 g ZnSO4
d. NOTA
B 297. Hydrogen forms a bridge with the following, except;
a. Fluorine c. oxygen
b. Magnesium d. Polypeptides
B 298. The ff. are drug/pharmaceutical agents that exhibit polymorphism, except;
a. theobroma oil c. chloramphenicol
b. penicillin d. carbamazepine
A 299. Supercooled liquids in which molecules are arranged in a random manner
a. amorphous solids c. crystalline solids
b. liquid crystals d. powders