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2017revisedclassificationofseizures 180110120548
2017revisedclassificationofseizures 180110120548
Seizures
Torbjörn Tomson, Emilio Perucca, Ingrid Scheffer, Jackie French, Yue-Hua Zhang
Satish Jain, Gary Mathern, Sam Wiebe, Edouard Hirsch, Sameer Zuberi, Nico Moshe
Classification of Epilepsies
• a multilevel classification
• designed to cater to classifying epilepsy in different clinical
environments
• This is in acknowledgement of the wide variation in resources
around the world
• meaning that different levels of classification will be possible
depending on the resources available to the clinician making
the diagnosis
• a diagnosis at all three levels should be sought as well as the
etiology of the individual’s epilepsy
Seizure types
Focal Generalized Unknown
Etiology
onset onset onset Structural
Co-morbidities
Genetic
Immune
Unknown
Epilepsy Syndromes
Background
• Awareness unknown:
Sometimes it’s not possible to know if a person is aware or
not, for example if a person lives alone or has seizures only at
night. In this situation, the awareness term may not be used
or it would be described as awareness unknown.
• Generalized seizures:
These are all presumed to affect a person’s awareness or
consciousness in some way.
Thus no special terms are needed to describe awareness in
generalized seizures.
Motor and Other Symptoms in Focal
Seizures
• It is also possible for a focal aware or impaired awareness
seizure to be sub-classified as:
• Auras:
Used to describe symptoms a person may feel in the
beginning of a seizure
These early symptoms may be the start of a seizure.
Describing Generalized Onset Seizures
• Generalized motor seizure:
The generalized tonic-clonic seizure term is still used to
describe seizures
This loosely corresponds to “grand mal.”
• Complex partial
• Simple partial
• Partial
• Psychic
• Dyscognitive
• Secondarily generalized tonic-clonic
New Expanded Classification
Seizure types
Focal Generalized Unknown
Etiology
onset onset onset Structural
Co-morbidities
Genetic
Immune
Unknown
Epilepsy Syndromes
Definition of Epilepsy
• What do with
– Multifocal epilepsies? focal
– Hemispheric epilepsies? focal
Unknown Epilepsy
Genetic
Immune
Unknown
Epilepsy Syndromes
Epilepsy Syndromes
• refers to a cluster of features incorporating seizure types, EEG,
and imaging features that tend to occur together
Idiopathic Generalized
Epilepsies
Childhood Juvenile
Absence Absence
Epilepsy Epilepsy
Juvenile Generalized
Myoclonic Tonic-Clonic
Epilepsy Seizures Alone
https://www.epilepsydiagnosis.org
Benign
• Many epilepsies not benign
– CAE :– psychosocial impact
– BECTS :– learning concerns
• Replaced by terms:
a) Self-limited: likely spontaneous resolution of a
syndrome
b) Pharmacoresponsive: syndrome will be likely to be
controlled with appropriate antiepileptic therapy
• No longer use:
– Malignant
– Catastrophic
Epileptic Encephalopathies
• Developmental encephalopathy
• May begin in utero
• Post birth
• Epileptic encephalopathy
• Can occur at any age
• May have remediable component – right vs wrong AED
• Move towards GENE encephalopathy
• eg. CDKL5 encephalopathy, SCN2A encephalopathy
Old terms
‘Symptomatic Generalized Epilepsies’
• Used for two different
Symptomatic Generalized
groups of disorders
Epilepsies
Developmental
and/or (Static)
Epileptic Encephalopathies
Encephalopathies
ILAE Classification of the Epilepsies
• Simplified the framework
• Etiology – consider at all stages
• Developmental and/or Epileptic Encephalopathies
• Self-limited, pharmaco-responsive
• Genetic Generalized Epilepsies
– Idiopathic Generalized Epilepsies = CAE, JAE, JME, GTCA
• Symptomatic Generalized Epiliepsies used for both
Developmental and Epileptic Encephalopathies
(static) Encephalopathy with Epilepsy
Impact on Clinical Care and Practice
• New classification framework will
• Change the approach to diagnosis in the clinic
• Be applied to patients and guide management
• Updates terminology to reflect
current thinking
• Scientific advances