Root word Myo- (muscle) Hemo- (blood)

Protein type globular Globular

# peptide chain 1 4 2+2 subunits
Impt Amino acid His His
But for HbF (fetal) 2+2
HbF (fetal): In , His  Ser
HbF is a weak binder of 2,3BPG
( 2.3BPG is an inhibitor of Hb function)
Primary level of Homologous proteins; 18% Homologous proteins; 18%
structure Conservative substitution
Highest level of 30 40
structure (8 -helices; no  structure)
Prosthetic group 1 heme 4 heme
Target Ligand oxygen oxygen

Function Bind & release O in muscles Take O from lungs and onto tissues
Affinity for O higher Lower
Cooperativity Present
(Allosteric Regulation)