GHS Classification Result

ID： 20A2186
CAS： 122-99-6 Year Classified: FY2008
Chemic2-phenoxyethanol Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification

1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.

Flammable gases （including

2
chemically unstable gases） Not applicable - - - - Liquid (GHS definition)

3 Aerosols Not applicable - - - - Not aerosol products.

4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)

5 Gases under pressure Not applicable - - - - Liquid (GHS definition)

6 Flammable liquids Not classified - - - - Its flash point is 127degC (closed) (ICSC (J) (2003)), which is above 93degC.

7 Flammable solid Not applicable - - - - Liquid (GHS definition)

Self-reactive substances and There are no chemical groups present in the molecule associated with explosive or self-
8
mixtures Not applicable - - - -
reactive properties.

Its autoignition point is 535degC (Solvents Handbook, Ohmsha Ltd. (1994)), which is above
9 Pyrophoric liquids Not classified - - - -
70degC.

10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)

11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.

Substances and mixtures which, in

The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge,
12 contact with water, emit flammable Not applicable - - - -
As, Se, Sn, Sb, Te, Bi, Po, At).
gases
The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only
13 Oxidizing liquids Not applicable - - - -
to carbon or hydrogen.

14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)

15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure

16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
Since its rat LD50 = 2937 mg/kg for male and 4013 mg/kg for female (GLP-compliant) (SIDS
1 Acute toxicity （Oral） Not classified - - - - (accessed in November 2008)), the substance was classified into the "Not classified" category
using the JIS classification criteria (Category 5 in the United Nations classification).

Its rabbit LD50 is represented by six values ranging from 2257 mg/kg to 5548 mg/kg (SIDS
1 Acute toxicity （Dermal） Not classified - - - -
(accessed in November 2008)). All values fall under the "Not classified" category.

1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid (GHS definition)

1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.

 Acute toxicity （Inhalation: Dusts and
1 mists）
2 Skin corrosion/irritation
3 Serious eye damage/eye irritation
4 Respiratory sensitization
4 Skin sensitization
5 Germ cell mutagenicity
6 Carcinogenicity
7 Reproductive toxicity
Specific target organ toxicity - Single
8
exposure
Classification not possible - -
Not classified - -
Category 2B - Warning
Classification not possible - -
Not classified - -
Not classified - -
Not classified - -
Category 2 Health Hazard Warning
Category 3 （Narcotic effects） Exclamation mark Warning
- -
- -
H320 : Causes eye irritation
- -
- -
- -
- -
H361 : Suspected of damaging
fertility or the unborn child
H336 : May cause drowsiness or dust/fume/gas/mist/vapours/sp In oral administration tests using rats or mice, temporal comatose, reduction of activity, and
dizziness (narcotic effects)
No data available.
In skin irritation tests on rabbits using the test substance of technical grade (OECD TG 404),
the substance was found to be not irritating (SIDS (accessed in November 2008)). In human
studies, of 2736 patients patch-tested, none had signs of irritant reactions. In other human skin
irritation tests, there are several reports concluding that the substance is not irritating (SIDS
(accessed in November 2008). Thus, it was classified into the "Not classified" category.
P305+P351+P338 : IF IN EYES:
Rinse cautiously with water for
several minutes. Remove contact
lenses, if present and easy to do. In eye irritation tests using rabbits, Draize scores were reported to be 0 for cornea, 5 for iris,
Continue rinsing. and 8-14 for conjunctiva (SIDS (accessed in November 2008). It is rated as R36 in the EU
P337+P313 : If eye irritation classification (EU-Annex 1 (accessed in November 2008)). Based on this information, the
persists: Get medical substance was classified into Category 2B.
advice/attention.
P264 : Wash ... thoroughly after
handling.
No data available.
Two different guinea pig maximization tests found the substance not sensitizing (SIDS
(accessed in November 2008)). In human studies, patch tests involving 501 patients found the
substance not sensitizing (SIDS (accessed in November 2008)). In addition, three different
patch tests, with each involving 2736, 3726, or 25 patients, also found the substance not
sensitizing (SIDS (accessed in November 2008)). Thus, the substance was classified into the
"Not classified" category.
Since both chromosomal aberration tests using bone marrow of rats (in vivo mutagenic tests
using somatic cells) and micronucleus tests using erythrocytes of mice that underwent forced
oral administration (in vivo mutagenic tests using somatic cells) gave negative results, the
substance was classified into the "Not classified" category (SIDS (accessed in November
2008)). Regarding in vitro mutagenicity tests, Ames tests and chromosomal aberration tests
using CHO cells gave negative results (NTP DB (1989), SIDS (accessed in November 2008)).
In 104-week carcinogenicity tests using rat or mice that underwent oral administration through
drinking water, no increase in incidences of tumors or tumor-related findings were noted in
both species and sexes (Results from Carcinogenicity Studies (Ministry of Health, Labour and
Welfare)). In addition, FDA cancer models predict the substance to be non-carcinogenic to
both sexes of rats and mice, though the models do not involve real test results related to
carcinogenicity (SIDS (accessed in November 2008)). Based on this information, the substance
was classified into the "Not classified" category.
P308+P313 : IF exposed or
concerned: Get medical
advice/attention.
P201 : Obtain special In two-generation reproduction tests using mice that underwent oral administration, the
instructions before use. reduced body weight and increased mortality in neonates were noted at doses that induce
P202 : Do not handle until all general toxicity to parental animals (NTP DB (1989, 1984)). Based on this description, the
safety precautions have been substance was classified into Category 2. As additional notes, in the test in which rabbits
read and understood. underwent dermal exposure during the organogenic period, no adverse effects of exposure on
P281 : Use personal protective offspring were detected at doses that induced toxic symptoms in parental animals (SIDS
equipment as required. (accessed in November 2008)).
P405 : Store locked up.
P501 : Dispose of
contents/container to ...
P304+P340 : IF INHALED:
Remove victim to fresh air and
keep at rest in a position
comfortable for breathing.
P403+P233 : Store in a well-
ventilated place. Keep container
tightly closed.
P261 : Avoid breathing
ray. ataxia were noted (SIDS (accessed in November 2008)). And since this substance is used as an
P271 : Use only outdoors or in a anesthetic (HSDB (2003)), the substance was classified into Category 3 (narcotic effects).
well-ventilated area.
P312 : Call a POISON CENTER
or doctor/physician if you feel
unwell.
P405 : Store locked up.
P501 : Dispose of
contents/container to ...
 In 13-week repeated oral administration tests using rats, NOAEL was 80 mg/kg/day and
LOAEL was 400 mg/kg/day; kidney inflammation was detected at the dose of 400 mg/kg/day
or higher which is above Category 2 guidance values (SIDS (accessed in November 2008)).
However, since NOAEL is within the range of Category 2 guidance values, toxic effects that
may occur at the upper limit of Category 2 guidance values are unclear. In 90-day repeated
Specific target organ toxicity - dermal exposure tests using rabbits, no adverse effects of treatment were noted in clinical
9
Repeated exposure Classification not possible - - - -
chemical examinations as well as hematologic and histopathological examinations other than
sporadic observation of mild erythema on the skin at the dose of 500 mg/kg/day; NOAEL was
500 mg/kg/day (SIDS (accessed in November 2008)). These results indicate that the
substance falls under the "Not classified" category for dermal route; however, since effects of
the substance through other administration routes are unclear, it was classified into the
"Classification not possible" category.

10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
Since its 96-hour LC50 = 344 mg/L for fish (fathead minnow), 48-hour EC50 is > 500 mg/L for
11 Hazardous to the aquatic environment Not classified - - - - crustaceans (Daphnia magna), and 72-hour EbC50 is > 500 mg/L for algae (Scenedesmus)
（Acute）
(SIDS, 2006), the substance was classified into the "Not classified" category.

Hazardous to the aquatic environment - - - - Since it is water soluble (water solubility = 28.9 g/L (SIDS, 2006) and its classification for acute
11 （Long-term） Not classified toxicity is "Not classified", the substance was classified into the "Not classified" category.