DRUG NAME MECHANISM OF INDICATION / CONTRAINDICATION ADVERSE EFFECT

NURSING RESPONSIBILITIES
ACTION
GENERIC: Assessment
Ampicillin Ampicillin bactericidal INDICATIONs: CNS: Lethargy,  History: Allergies to
BRAND: activity via inhibition of
 Treatment of infections caused by susceptible hallucinations, penicillins,
Ampicin bacterial cell wall
Omnipen synthesis by binding strains of Shigella, Salmonella, Escherichia coli, seizures cephalosporins, or other
Principen one or more of the Haemophilus influenzae, Proteus mirabilis, CV: CHF allergens; renal
UL Ampicillin penicillin binding GI: Glossitis,
Neisseria gonorrhoeae, enterococci, gram- disorders; lactation
proteins (PBPs). stomatitis,
CLASS Exerts bacterial
positive organisms (penicillin G–sensitive  Physical: Culture
autolytic effect by staphylococci, streptococci, pneumococci) gastritis, sore infected area; skin color,
THERAPEUTIC: inhibition of certain  Meningitis caused by Neisseria meningitidis mouth, furry lesion; R, adventitious
Broad-spectrum PBPs related to the  Unlabeled use: Prophylaxis in cesarean section in tongue, black sounds; bowel sounds;
antibacterial activation of a
certain high-risk patients “hairy” tongue, CBC, LFTs, renal
bacterial autolytic
nausea, vomiting, function tests, serum
process.
PHARMACOLOGIC: CONTRAINDICATION and PRECAUTIONS: diarrhea,
Penicillin derivative
electrolytes, Hct,
SOURCE: abdominal pain, urinalysis
DOSAGE:  Contraindicated with allergies to penicillins,
http://www.antimicrob bloody diarrhea,
100 mg/kg/day PO or IV cephalosporins, or other allergens. Interventions
e.org/drugpopup/ampici enterocolitis,
divided in 2 or 4 doses  Culture infected area
llin.htm  Use cautiously with renal disorders.
200 mg/kg/day PO or IV pseudomembrano before treatment;
divided in 2 or 4 doses us colitis,
(in severe infection) reculture area if response
nonspecific is not as expected.
ROUTE:
DRUG TO DRUG INTERACTION: hepatitis
IV, IM  Check IV site carefully
ORAL You should not take ampicillin if you are taking GU: Nephritis
Theracrys [BCG live (intravesical)].
for signs of thrombosis
Hematologic: Ane or drug reaction.
Medications that have serious interactions with mia,  Do not give IM
ampicillin include the following: thrombocytopenia, injections in the same
leukopenia, site; atrophy can occur.
 Vivotif (live typhoid vaccine) neutropenia, Monitor injection sites.
 Warfarin (Jantoven, Coumadin) prolonged  Administer oral drug on
 Methotrexate (Trexall, Rasuvo, Otrexup)
bleeding time an empty stomach, 1 hr
Hypersensitivity:
 Magnesium citrate (Citroma, Citrate of before or 2 hr after meals
Magnesia)
Rash, fever, with a full glass of
wheezing,
 Exenatide (Byetta, Bydureon) water; do not give with
anaphylaxis fruit juice or soft drinks.
 Acid reflux drugs, such as  Local: Pain,
like Prevacid (deslansoprazole), Prilosec (ome Teaching points
prazole), Nexium (esomeprazole), and
phlebitis,
 Protonix (pantoprazole) thrombosis at  Take this drug around-
 Tramadol, (Ultram, Ultracet) injection site the-clock.
 Doxycycline (Vibramycin, Doryx) (parenteral)  Take the full course of
 Tiagabine (Gabitril)
 Other: Superi therapy; do not stop
nfections— taking the drug if you
 Bupropion (Wellbutrin, Zyban, Forfivo XL)
oral and rectal feel better.
 Allopurinol (Zyloprim, Lopurin, Aloprim) moniliasis,  Take the oral drug on an
vaginitis empty stomach, 1 hour
DRUG TO FOOD INTERACTION:
before or 2 hours after
Grapefruit interacts with some antibiotics, but it's meals; do not take with
not clear whether this includes ampicillin. Be safe, fruit juice or soft drinks;
and avoid eating grapefruit or drinking grapefruit the oral solution is stable
juice while taking the medication for 7 days at room
temperature or 14 days
refrigerated.
 This antibiotic is specific
to your problem and
should not be used to
self-treat other
infections.
 You may experience
these side effects:
Nausea, vomiting, GI
upset (eat frequent small
meals), diarrhea.
 Report pain or
discomfort at sites,
unusual bleeding or
bruising, mouth sores,
rash, hives, fever,
itching, severe diarrhea,
difficulty breathing.