Megaloblastic anemias can be caused by gastric resection, nutritional deficiency, or both. Pernicious anemia is caused by an autoimmune reaction involving antibodies against intrinsic factor or parietal cells. Blood cells are produced in the bone marrow. Cobalamin transport is mediated by both intrinsic factor and transcobalamin II. Basophilic stippling occurs in megaloblastic anemia. Haptocorrin is also called transcobalamin I. Vitamin B12 is absorbed into the blood with the help of transcobalamin I. Causes of aplastic anemia include Fanconi anemia, radiation, drugs, chemicals, or all of these.
Megaloblastic anemias can be caused by gastric resection, nutritional deficiency, or both. Pernicious anemia is caused by an autoimmune reaction involving antibodies against intrinsic factor or parietal cells. Blood cells are produced in the bone marrow. Cobalamin transport is mediated by both intrinsic factor and transcobalamin II. Basophilic stippling occurs in megaloblastic anemia. Haptocorrin is also called transcobalamin I. Vitamin B12 is absorbed into the blood with the help of transcobalamin I. Causes of aplastic anemia include Fanconi anemia, radiation, drugs, chemicals, or all of these.
Megaloblastic anemias can be caused by gastric resection, nutritional deficiency, or both. Pernicious anemia is caused by an autoimmune reaction involving antibodies against intrinsic factor or parietal cells. Blood cells are produced in the bone marrow. Cobalamin transport is mediated by both intrinsic factor and transcobalamin II. Basophilic stippling occurs in megaloblastic anemia. Haptocorrin is also called transcobalamin I. Vitamin B12 is absorbed into the blood with the help of transcobalamin I. Causes of aplastic anemia include Fanconi anemia, radiation, drugs, chemicals, or all of these.
a) Gastric resection b) nutritional deficiency c) all of the above d) none of these 2. The underlying type A gastritis that causes pernicious anemia is immunologically related to: a) autoantibody to IF b) low serum gastrin c) autoantibody to parietal cells d) both A and C 3. Blood cells--red, white and platelets--are made in: a) Kidney b) Bone marrow c) Liver d) None of above 4. Cobalamin transport is mediated by: a) IF b) TC II c) none of these d) all of the above 5. The life span of monocyte in blood: a) 20-40hour b) 120days c) 40-60 hour d) None of these 6. Basophilic stippling occur in a) Sidroblastic anemia b) Lead poisoning anemia c) Megaloblastic anemia d) None of above 7. Haptocorrin is also called: a) Transcobalamine I b) Taranscobalamine II c) Taranscobalamine III d) Taranscobalamine IV 8. Vitamin B12 absorbed in the blood with the help of protein: a) Taranscobalamine I b) Amnionless c) Haptocorrin d) none of these 9. Causes of aplastic anemia: a) Fanconi anemia b) Radiation c) Drugs d) Chemicals e) All of these 10. Thalassemia is divided into: a) 2 types b) 3 types c) 4 types d) 6 types 11. The in vitro death of fetus(hydrops fetalis) is caused by: a) 4 gene deletion b) 3 gene deletion c) 2 gene deletion d) 1 gene deletion 12. Beta thalassemia is divided into: a) 3 types b) 2 types c) 1 types d) Has no type 13. HbF has globin chain: a) α2β2 b) α2γ2 c) α2δ2 d) none of these 14. Neural tube defect is caused by: a) Vitamin B12 deficiency b) Folate deficiency c) Both a and b d) None of these 15. Hemosidren is visible in light microscopy by: a) Pearls staining b) Gram staining c) ZN staining d) Muci-carmine staining