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1. All are inhibitors of oxidative phosphorylation except?

a. Carboxin
b. Oligomycin
c. Valinomycin
d. Atractyloside

2. In starvation activities of all of the following enzyme is increased

except?
a. Pyruvate carboxylase
b. Pyruvate kinase
c. PEP carboxykinase
d. Glucose 6 phosphatase

3. Decreased energy production in thiamine deficiency is due to?

a. It is a cofactor for oxidative reduction
b. It is required for transamination reactions
c. It is a coenzyme for alpha ketoglutarate dehydrogenase and
pyruvate dehydrogenase in citric acid cycle
d. It is a coenzyme for transketolase in hexose monophosphate shunt

4. In competitive inhibition, the relation of Km and Vmax is

a. Km and Vmax are the same
b. Km increases and Vmax is the same
c. Km decreases and Vmax increases
d. Km and Vmax decreases

5. Sphingomyelinase deficiency is characteristic of ?

a. Fabry disease
b. Krabbe’s disease
c. Tay Sachs disease
d. Niemann Pick disease

6. In glycolysis, the first committed step is catalyzed by

a. 2, 3 DPG
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b. Glucokinase
c. Hexokinase
d. Phosphofructokinase

7. UAC to UAG is
a. Silent mutation
b. Missense mutation
c. Non sense mutation
d. Frameshift muation
8. Treatment of Multiple Carboxylase Deficiency is:
a. Biotin
b. Pyridoxine
c. Thiamine
d. Folic acid

9. Alpha oxidation of fatty acid takes place in?

a. ER
b. Golgi apparatus
c. Mitochondria
d. Peroxisomes

10.Triacylglycerol synthesis is enhanced by:

a. Cortisol
b. Glucagon
c. Insulin
d. Epinephrine

11.The reaction : succinyl Co A = acetoacetate and acetoacetyl Co A =

sucinate occurs in all of the following except ?

a. Brain
b. Striated muscle
c. Liver
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d. Cardiac muscle

12.Reverse cholesterol transport is a function of

a. LDL
b. VLDL
c. HDL
d. Chylomicrons

13.Which hormone is synthesized from Tyrosine?

a. Calcitriol
b. Calcitonin
c. Thyroxine
d. Cortisol

14.Malonate inhibits following enzyme of Krebs cycle

a. aconitase
b. alpha ketoglutarate dehydrogenase
c. succinate dehydrogenase
d. enolase

15.Gluconeogenesis takes place in

a. Mitochondria
b. Cytosol
c. Both mitochondria and cytosol
d. Endoplasmic reticulum

16.Northern blotting technique is used for

a. DNA
b. RNA
c. Proteins
d. Nucleoproteins
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17.Rate limiting step in fatty acid synthesis is

a. Acetyl CoA synthase
b. Acetyl CoA carboxylase
c. HMG CoA synthase
d. HMG CoA reductase

18.True about 3- hydroxy 3-methyl glutaryl Co A:

a. It is found in cytoplasm and mitochondria
b. It is an intermediate compound in cholesterol synthesis
c. It is an intermediate compound in ketone body synthesis
d. All of the above

19.Increased ratio of insulin to glucagon causes

a. Decreased levels of cyclic AMP
b. Decreased levels of lipoprotein lipase
c. Decreased amino acid synthesis
d. Enhanced lipolysis in adipose tissue

20.Which of the following amino acid is excreted in urine in maple

syrup urine disease
a. Tryptophan
b. Phenylalanine
c. Valine
d. Arginine

21.Endogenous triglycerides are maximum in

a. Chylomicrons
b. VLDL
c. LDL
d. HDL

22.How many ATP are formed in HMP pathway?

a. 1
b. 2
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c. 10
d. none

23.In glutathione which amino acid is reducing agent

a. Glutamic acid
b. Glycine
c. Cysteine
d. Alanine

24.Muscle cannot make use of glycogen for energy because of deficiency

of

a. Glucokinase
b. Phosphoglucomutase
c. Glucose 6 phosphatase
d. Muscle phosphorylase

25.Increased uric acid levels are seen in which glycogen storage disorder

a. Von Gierke’s
b. Pompe’s
c. Anderson
d. Cori’s

26.Epinephrine and glucagon have which one of the following effects on

hepatic glycogen metabolism?

a. Both glycogen phosphorylase and glycogen synthase are activated by

phosphorylation but at significantly different rates.
b. Glycogen phosphorylase is inactivated by the resulting rise in calcium,
whereas glycogen synthase is activated.
c. Glycogen phosphorylase is phosphorylated and active, whereas
glycogen synthase is phosphorylated and inactive.
d. The net synthesis of glycogen is increased.
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27. Which of the following is an activator of LCAT

a. Apo B100
b. Apo B48
c. Apo E
d. Apo A1

28. In familial hypercholesterolemia there is deficiency of

a. LDL receptor
b. Apoprotein A
c. Apoprotein C
d. Lipoprotein lipase

29. Which intermediate product of urea cycle enters in Kreb’s cucle

a. Arginosuccinate
b. Arginine
c. Fumarate
d. Malate

30. Urea is produced by the enzyme

a. Urease
b. Uricase
c. Glutaminase
d. Arginase

31. Which is a X-linked urea cycle disorder?

a. Hyperammonemia type I
b. Hyperammonemia type II
c. HHH syndrome
d. Arginosuccinic aciduria
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32.Heme is synthesized from

a. Succinyl-CoA and glycine
b. Active acetate and glycine
c. Active succinate and alanine
d. Active acetate and alanine

33. Acute intermittent porphyria is caused due to deficiency of

a. Uroporphyrinogen I synthase
b. Uroporphyrinogen III synthase
c. Coproporphyrinogen oxidase
d. Uroporphyrinogen decarboxylase

34.To determine the global patterns of gene expression in two different

types of tumor cells in order to develop the most appropriate form of
chemotherapy for each patient following technique would be most
appropriate
a. Enzyme-linked immunosorbent assay
b. Microarray
c. Northern blot
d. Southern blot

35.Restriction endonucleases recognize and cut a certain sequence of

a. Single stranded DNA
b. Double stranded DNA
c. RNA
d. Protein

36.Which of the following is most likely to be the recognition sequence

for restriction endonuclease?
a. AAGAAG
b. AAGAGA
c. AAGCTT
d. AAGGAA
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37.RFLP is used for

a. analysis of chromosome structure
b. DNA estimation
c. Synthesis of nucleic acid
d. Detecting proteins in a cell

38. In essential pentosuria, urine contains

a. D-Ribose
b. D-Xylulose
c. L-Xylulose
d. D-Xylose

39.Enzyme deficiency in hereditary fructose intolerance

a. Fructokinase
b. Aldolase A
c. Aldolase B
d. triokinase

40.The best known cause of galactosemia is due to deficiency of

a. Galactose 1-phosphate uridyl transferase
b. Phosphoglucomutase
c. Galactokinase
d. Lactose synthase

41. Telomerase is
a. DNA dependent RNA polymerase
b. RNA dependent DNA polymerase
c. RNA dependent RNA polymerase
d. DNA dependent DNA polymerase

42. What is attached to 3’ end of m RNA after transcription?

a. Poly A tail
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b. 7 methyl guanosine
c. CCA
d. Intron

43. Modified nucleotide is seen in

a. t RNA
b. m RNA
c. hn RNA
d. r RNA

44. Nitric oxide is formed from

a. Histidine
b. Arginine
c. Tryptophan
d. Tyrosine

45.In the genetic disease, Xeroderma Pigmentosum, the cells fail to

repair damaged DNA, due to the defect in
a. Double stranded break repair
b. Base excision repair
c. Mismatch repair
d. Nucleotide excision repair

46.Cofactor for enzyme carbonic anhydrase is

a. Copper
b. Zinc
c. Molybdenum
d. Manganese

47.Transketolase activity is seen with which vitamin

a. Vit B1
b. Vit B2
c. Vit B3
d. Vit B6
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48.Vitamin K is involved in
a. Carboxylation
b. Decarboxylation
c. Transamination
d. Deamination

49. Primase functions as

a. Joining DNA fragments
b. Synthesising small RNA fragments during translation
c. Synthesizing small RNA fragments during DNA replication
d. Unwinding of DNA

50.Heme biosynthesis occurs in all except

a. Bone marrow
b. Liver
c. RBC
d. Osteoclast