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GUM Approach
GUM Approach
FOR ESTIMATION OF
MEASUREMENT
UNCERTAINTY IN
ANALYTICAL CHEMISTRY
D. Von Mollendorf
• Results
Nordtest approach was implemented:
* In most cases uncertainty values was found to be higher than previously
found using the modelling approach.
* Proved to have been a better estimation of the real variation of our
methods, mainly due to maximising the probability of including all
uncertainty contributions
* Higher uncertainties was in good agreement with inter laboratory
comparison results and quality control data.
• Recommendations
Nordtest approach - holistic approach - minimise risk of excluding important
uncertainty sources & easy to use already existing data
Uncertainty Approaches
Definition of the Measurand
Yes No Yes No
Because bias will in most cases vary with different matrix & concentration ranges
* Ideally use several different reference materials/certified materials & several
PT results
* To prevent that bias is grossly under estimated or grossly over estimated
RMSbias
• Accounts for average bias of the laboratory:
2 Uncertainty components
Recommendations
• Use the Modeling approach
If you have - Competence and time
- Data on all important influencing quantities
Thank you!